Author details

Full Name

Christopher J Lengner

Affiliation

ORCID

Career Start Year

2001

Papers

111

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36722667	High autophagic vesicle content marks facultative stem cells of the gut.		2023
38036590	Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment.	Nat Commun	2023
37753470	Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions.		2023
37591698	and mutations synergise to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer.		2023
37477898	Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle.		2023
37398283	Musashi-2 (MSI2) regulation of DNA damage response in lung cancer.		2023
37318881	LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3.		2023
37302654	Patient-Induced Pluripotent Stem Cell-Derived Hepatostellate Organoids Establish a Basis for Liver Pathologies in Telomeropathies.		2023
37044068	Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells.		2023
37489330	The Tumor Suppressor Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish.		2023
34894222	TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.	Inflammatory Bowel Diseases	2022
36031151	Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox-Based Lineage Tracing.	Cellular and Molecular Gastroenterology and Hepatology	2022
35444258	Dormant state of quiescent neural stem cells links Shank3 mutation to autism development.	Molecular Psychiatry	2022
36007109	Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.	Cancer Res	2022
36276637	Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.	Theranostics	2022
35559731	GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells.	eLife	2022
35798701	Author Correction: Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-ÎºB survival pathway.	Nat Commun	2022
35477756	Î²-Hydroxybutyrate suppresses colorectal cancer.	Nature	2022
34593610	MYC Hyperactivates Wnt Signaling in /-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of .	Molecular Cancer Research	2021
34115987	Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states.	Cancer Cell	2021
33620315	Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation.	eLife	2021
33462238	Dll1<sup>+</sup> quiescent tumor stem cells drive chemoresistance in breast cancer through NF-ÎºB survival pathway.	Nat Commun	2021
33941035	LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.	Scandinavian Journal of Gastroenterology	2021
34029742	A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes.	Cell Mol Gastroenterol Hepatol	2021
33438789	Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells.	Stem Cells	2021
33373440	Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.	Endocrinology	2021
33352108	Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency.	Molecular Cell	2021
33108751	MTORC1 and the Rebirth of Stemness.	Developmental Cell	2020
32294437	BCR-Induced Ca Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.	Cell Reports	2020
32457396	The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.	Cell Research	2020
32597939	Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.	Journal of Cell Biology	2020
32791156	MTorc1 at the Crossroads of Facultative Intestinal Stem Cell Activation.	Cellular and Molecular Gastroenterology and Hepatology	2020
33060623	Author Correction: MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists.	Nature Communications	2020
32726617	Cycling Stem Cells Are Radioresistant and Regenerate the Intestine.	Cell Reports	2020
30779922	MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.	Gastroenterology	2019
31776290	Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.	Sci Transl Med	2019
30858603	In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease.	Nature Neuroscience	2019
30799274	Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.	Stem Cell Reports	2019
29805107	Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating.	Stem Cell Reports	2018
30068703	The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.	Genes and Development	2018
30242124	The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation.	Journal of Biological Chemistry	2018
30380424	Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD Synthesis.	Cell Reports	2018
29745807	Epigenetic remodeling and modification to preserve skeletogenesis in vivo.	Connective Tissue Research	2018
28303901	Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.	Nature Communications	2017
28732600	Hierarchy and Plasticity in the Intestinal Stem Cell Compartment.	Trends in Cell Biology	2017
28985520	Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized.		2017
28899010	Modelling APOE É¿3/4 allele-associated sporadic Alzheimer's disease in an induced neuron.	Brain	2017
28718412	Stem Cells, Cancer, and MUSASHI in Blood and Guts.		2017
28934364	The histone variant macroH2A confers functional robustness to the intestinal stem cell compartment.	PLoS ONE	2017
28481227	Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration.	J Clin Invest	2017