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Author Details

Timothy A Graubert
Massachusetts General Hospital
1993
117
60
PMIDPaper TitleJournal TitlePublished Year
37967363R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.Cancer Res2024
35962750Supporting Patients with Cancer after Dobbs v. Jackson Women's Health Organization.Oncologist2022
35852437Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.Oncologist2022
34546980U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.J Clin Invest2021
33689684A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.Cell Chem Biol2021
34583982Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.Mol Cancer Ther2021
32347921SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.Blood2020
31837959Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.Lancet Haematol2020
31860140A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia.Cancer2020
32678290Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy.Leukemia2020
32232484Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia.Blood2020
30635634TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.Leukemia2019
30827681Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.Cell2019
31080550Targeting R-loop-associated ATR response in myelodysplastic syndrome.Oncotarget2019
30422308Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.Cancer2019
28744009Efficacy and safety of midostaurin in patients with advanced systemic mastocytosis: 10-year median follow-up of a phase II trial.Leukemia2018
30054334Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.Cancer Res2018
30207916Mutation Clearance after Transplantation for Myelodysplastic Syndrome.N Engl J Med2018
30033577Impact of lenalidomide use among non-transfusion dependent patients with myelodysplastic syndromes.Am J Hematol2018
30380364Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.N Engl J Med2018
29386642Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.Nat Commun2018
29724895High <i>NPM1</i>-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.Blood2018
29515031Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.JCI Insight2018
29315296Genomics in childhood acute myeloid leukemia comes of age.Nat Med2018
27940478Splicing factor gene mutations in hematologic malignancies.Blood2017
35172484Combined Targeted Therapy for <i>BRAF</i>-Mutant, Treatment-Related Acute Myeloid Leukemia.JCO Precis Oncol2017
28257700Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1.Mol Cell2017
27740633Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.Leukemia2017
28067246Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.Nat Commun2017
28034990Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Haematologica2017
27070704The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Cancer Cell2016
26631115Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.Blood2016
27959731TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.N Engl J Med2016
27959687Case 37-2016. An 86-Year-Old Woman with Leukocytosis and Splenomegaly.N Engl J Med2016
27479034The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Cancer Cell2016
27181063Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.Exp Hematol2016
25311244U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.Leukemia2015
26305651Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.JAMA2015
26331834Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.J Mol Diagn2015
26492932Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.Blood2015
26689913Patterns and functional implications of rare germline variants across 12 cancer types.Nat Commun2015
25926135Health care utilization and end-of-life care for older patients with acute myeloid leukemia.Cancer2015
25965570Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.Cancer Cell2015
25961772Prognostic understanding, quality of life and mood in patients undergoing hematopoietic stem cell transplantation.Bone Marrow Transplant2015
25798938Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.Nat Biotechnol2015
25469752Quality of life and mood of patients and family caregivers during hospitalization for hematopoietic stem cell transplantation.Cancer2015
25487151Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.Nature2015
24448499Integrated analysis of germline and somatic variants in ovarian cancer.Nat Commun2014
25207770A call to action for acute lymphoblastic leukemia.N Engl J Med2014
25311744AML genomics for the clinician.Semin Hematol2014
  • 1 - 50 of 117

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Collaborators

Timothy J Ley
Washington University School of Medicine
Co-authored papers 45
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 43
John F DiPersio
Washington University School of Medicine
Co-authored papers 37
Richard K Wilson
The Ohio State University
Co-authored papers 32
Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 31
Daniel C Link
Washington University School of Medicine
Co-authored papers 30
Elaine R Mardis
The Ohio State University
Co-authored papers 29
Peter Westervelt
Washington University School of Medicine
Co-authored papers 27
Sharon E Heath
Washington University School of Medicine.
Co-authored papers 26
Christopher A Miller
Washington University School of Medicine
Co-authored papers 21
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 19
Michael D McLellan
McDonnell Genome Institute, Washington University in St. Louis
Co-authored papers 19
Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 17
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 15
David E Larson
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 13
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 12
Daniel C Koboldt
Institute for Genomic Medicine, Nationwide Children's Hospital
Co-authored papers 12
Mark A Watson
Washington University School of Medicine
Co-authored papers 11
Vincent Magrini
The Ohio State University
Co-authored papers 11
Richard M Stone
Dana Farber Cancer Institute
Co-authored papers 10
Rakesh Nagarajan
Current or past members of the College of American Pathologists
Co-authored papers 9
David P Steensma
Novartis Institutes for BioMedical Research
Co-authored papers 9
Jeffery M Klco
St. Jude Children's Research Hospital
Co-authored papers 9
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 8
Rhonda E Ries
Clinical Research Division, Fred Hutchinson Cancer Research Center
Co-authored papers 8
Donna Neuberg
Co-authored papers 8
Sean McGrath
Harvard T.H. Chan School of Public Health
Co-authored papers 8
Tamara L Lamprecht
St. Jude Children's Research Hospital
Co-authored papers 8
Patrick Cahan
Johns Hopkins University
Co-authored papers 7
Ravi Vij
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Release 1.2