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Author Details

Chandra C Ghosh
The Wistar Institute
1999
64
30
PMIDPaper TitleJournal TitlePublished Year
36892943Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions.J Clin Invest2023
37142218Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.J Biol Chem2023
37328686Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment.Oncogene2023
36707623Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment.Oncogene2023
34687147Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4<sup>+</sup> T cells.Am J Transplant2022
35697801Regional infusion of a class C TLR9 agonist enhances liver tumor microenvironment reprogramming and MDSC reduction to improve responsiveness to systemic checkpoint inhibition.Cancer Gene Ther2022
35354906NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment.Oncogene2022
36223343Mitochondrial fitness and cancer risk.PLoS One2022
35177476Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability.Proc Natl Acad Sci U S A2022
34203268Emerging Advances of Nanotechnology in Drug and Vaccine Delivery against Viral Associated Respiratory Infectious Diseases (VARID).Int J Mol Sci2021
34433563A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression.Sci Adv2021
34482371Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets.Cell Death Discov2021
34451932Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity.Vaccines (Basel)2021
32435188Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins.Front Pharmacol2020
32780991Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment.Dev Cell2020
32723812The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells.Sci Signal2020
30310180Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function.Lab Invest2019
31530011IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α<i>-</i>regulated pseudohypoxic state.FASEB J2019
31406245Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits.Oncogene2019
31603851Aspergillus fumigatus-Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma.Immunohorizons2019
31542230Calcineurin inhibitors augment endothelial-to-mesenchymal transition by enhancing proliferation in association with cytokine-mediated activation.Biochem Biophys Res Commun2019
31097545Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth.J Biol Chem2019
30737270Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific <i>Coq6</i> Knockout Mice.J Am Soc Nephrol2019
31061095Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis.Mol Cell Biol2019
29979219Molecular Regulation of Acute Tie2 Suppression in Sepsis.Crit Care Med2018
28239661KLF2 and KLF4 control endothelial identity and vascular integrity.JCI Insight2017
28276491Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis.Sci Rep2017
26950361A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.Nat Med2016
27505672Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.Cancer Cell2016
26884170Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.Proc Natl Acad Sci U S A2016
25587041Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.Blood2015
26124089PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.Proc Natl Acad Sci U S A2015
25855898Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.Crit Care Med2015
25650317Adaptive mitochondrial reprogramming and resistance to PI3K therapy.J Natl Cancer Inst2015
25761062Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense.PLoS One2015
24908307Detecting Tie2, an endothelial growth factor receptor, by using immunohistochemistry in mouse lungs.Methods Mol Biol2014
25405070Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease).J Clin Cell Immunol2014
25083983Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis.Crit Care Med2014
24787070Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease.Am J Respir Crit Care Med2014
23303179Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.J Biol Chem2013
22411873Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).Blood2012
22975376Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.Cancer Cell2012
22890252Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*.Crit Care Med2012
22665799Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.Proc Natl Acad Sci U S A2012
22586065Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.Cancer Res2012
21224428Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.Mol Cancer Res2011
21885850Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.Arterioscler Thromb Vasc Biol2011
21421750Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.Am J Physiol Lung Cell Mol Physiol2011
20978188Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.Cancer Res2010
20696864Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IκBα.J Immunol2010
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Collaborators

Andrew V Kossenkov
The Wistar Institute
Co-authored papers 17
Samir M Parikh
The Ohio State University Wexner Medical Center
Co-authored papers 17
David W Speicher
Co-authored papers 8
Silvano Bosari
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Co-authored papers 5
David M Briscoe
Boston Children's Hospital
Co-authored papers 2
Ashani T Weeraratna
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine
Co-authored papers 2
Chi V Dang
Johns Hopkins University School of Medicine
Co-authored papers 2
Louise C Showe
The Wistar Institute
Co-authored papers 2
Johannes Wedel
Boston Children's Hospital
Co-authored papers 2
Subbian Ananth Karumanchi
Co-authored papers 2
Mukesh K Jain
Co-authored papers 1
Kaifeng Liu
Boston Children's Hospital
Co-authored papers 1
Sayantan Bose
Bose Institute
Co-authored papers 1
Guangjin Zhou
Co-authored papers 1
Yuan Lu
Co-authored papers 1
Joshua D Rabinowitz
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 1
Gun Ho Jang
Ontario Institute for Cancer Research
Co-authored papers 1
Meenhard Herlyn
Ellen and Ronald Caplan Cancer Center, The Wistar Institute
Co-authored papers 1
Daniel Goodman
Boston Children's Hospital
Co-authored papers 1
Faiyaz Notta
2Ontario Institute for Cancer Research
Co-authored papers 1
Michael W Donnino
Beth Israel Deaconess Medical Center and Harvard Medical School
Co-authored papers 1
A G Pramoda Sahankumari
Boston Children's Hospital
Co-authored papers 1
Daniel Cui Zhou
Washington University in St. Louis
Co-authored papers 1
Michael P O'Connell
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
Friedhelm Hildebrandt
Boston Children's Hospital
Co-authored papers 1
Steven Gallinger
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
Co-authored papers 1
Panjamaporn Sangwung
Co-authored papers 1
Aalim M Weljie
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Sarah Bruneau
Centre Hospitalier Universitaire de Nantes, Nantes Universite, Inserm
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Timna Agur
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Release 1.2