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Author Details

Christopher J Bakkenist
UPMC Hillman Cancer Center, University of Pittsburgh
1994
79
32
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36810257The schedule of ATR inhibitor AZD6738 can potentiate or abolish antitumor immune responses to radiotherapy.JCI Insight2023
37639904Metronomic dosing of ovarian cancer cells with the ATR inhibitor AZD6738 leads to loss of CDC25A expression and resistance to ATRi treatment.Gynecol Oncol2023
37145994Mitotic CDK1 and 4E-BP1 I: Loss of 4E-BP1 serine 82 phosphorylation promotes proliferative polycystic disease and lymphoma in aged or sublethally irradiated mice.PLoS One2023
35066692Dose-dependent bioavailability and tissue distribution of the ATR inhibitor AZD6738 (ceralasertib) in mice.Cancer Chemother Pharmacol2022
35507041Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice.Cancer Chemother Pharmacol2022
36130512Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression.Cell Rep2022
33351788Syngeneic tobacco carcinogen-induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden.JCI Insight2021
33513208Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice.PLoS Pathog2021
34223192Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients.Nat Cancer2021
34158341Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development.Mol Cancer Ther2021
30808762The neonatal Fc receptor is a pan-echovirus receptor.Proc Natl Acad Sci U S A2019
31665741The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.Nucleic Acids Res2019
31712441WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells.Proc Natl Acad Sci U S A2019
31239318IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.Cancer Immunol Res2019
31209037An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication.Proc Natl Acad Sci U S A2019
31176958Quantitative analysis of ATM phosphorylation in lymphocytes.DNA Repair (Amst)2019
31345392ATR inhibition sensitizes HPV<sup>-</sup> and HPV<sup>+</sup> head and neck squamous cell carcinoma to cisplatin.Oral Oncol2019
31311769Dormant origin signaling during unperturbed replication.DNA Repair (Amst)2019
29173750Role of Immunotherapy in Head and Neck Cancer.Semin Radiat Oncol2018
29952768ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation.J Clin Invest2018
30266203Regulation of the initiation of DNA replication in human cells.DNA Repair (Amst)2018
30316683ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer.Clin Colorectal Cancer2018
30559436Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA.Nat Commun2018
29568381Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements.Oncotarget2018
28888173LC-MS/MS assay for the quantitation of the ATR kinase inhibitor VX-970 in human plasma.J Pharm Biomed Anal2017
28254357RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.DNA Repair (Amst)2017
28213176LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.J Pharm Biomed Anal2017
28145510Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.Sci Rep2017
29123096ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1.Nat Commun2017
27259260ATM protein is deficient in over 40% of lung adenocarcinomas.Oncotarget2016
27235625Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.DNA Repair (Amst)2016
25560806Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.Gynecol Oncol2015
26517239The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Oncotarget2015
26517194ATM serine-1981 phosphorylation is a plausible biomarker.Cell Cycle2015
26438152Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma.BMC Cancer2015
26391293Chromatin perturbations during the DNA damage response in higher eukaryotes.DNA Repair (Amst)2015
26097887A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.Oncoscience2015
24799566Simian virus 40 large T antigen induces IFN-stimulated genes through ATR kinase.J Immunol2014
23370393Homologous chromosomes move and rapidly initiate contact at the sites of double-strand breaks in genes in Gâ¿¿-phase human cells.Cell Cycle2013
24312743Erratum: Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation: erratum.Biomed Opt Express2013
24045152Brd4 shields chromatin from ATM kinase signaling storms.Sci Signal2013
24038466ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.Nucleic Acids Res2013
24189535Stoichiometry of ubiquitin-binding proteins directs DSB repair.Cell Cycle2013
23900392Radiation therapy induces the DNA damage response in peripheral blood.Oncotarget2013
23577294Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation.Biomed Opt Express2013
22362778ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.J Biol Chem2012
23015593Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress.J Cell Sci2012
22909323Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes.J Proteome Res2012
22869596Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.J Cell Biol2012
22645362Homologous chromosomes make contact at the sites of double-strand breaks in genes in somatic G0/G1-phase human cells.Proc Natl Acad Sci U S A2012
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Collaborators

Serah Choi
University Hospitals Cleveland Medical Center and Case Comprehensive Cancer Center
Co-authored papers 14
Thomas P Conrads
Women's Health Integrated Research Center, Inova Health System
Co-authored papers 9
Brian L Hood
The Henry M. Jackson Foundation for the Advancement of Military Medicine
Co-authored papers 4
Simon C Watkins
Center for Molecular Imaging, University of Pittsburgh School of Medicine
Co-authored papers 4
Katherine Y Fu
University of Florida
Co-authored papers 2
George L Maxwell
Women's Health Integrated Research Center, Inova Health System
Co-authored papers 2
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 2
Gregory A Gibson
University of Pittsburgh
Co-authored papers 2
Bennett Van Houten
UPMC-Hillman Cancer Center, University of Pittsburgh
Co-authored papers 2
Kathleen M Darcy
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Co-authored papers 2
Nathan A Yates
University of Pittsburgh School of Medicine
Co-authored papers 1
Rohith Srivas
Amgen Inc.
Co-authored papers 1
Jennifer R Grandis
University of California san francisco
Co-authored papers 1
Nuno Bandeira
University of California
Co-authored papers 1
Uma R Chandran
Co-authored papers 1
John Paul Shen
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Jian Peng
University of Illinois
Co-authored papers 1
Daniel E Johnson
University of California San Francisco
Co-authored papers 1
Marc Hafner
Harvard Medical School
Co-authored papers 1
Riyue Bao
UPMC Hillman Cancer Center
Co-authored papers 1
Yunan Luo
Georgia Institute of Technology
Co-authored papers 1
Marjorie Romkes
Co-authored papers 1
Anish Bhaswanth Chakka
Co-authored papers 1
Xandra O Breakefield
Massachusetts General Hospital
Co-authored papers 1
Jianzhu Ma
Purdue University
Co-authored papers 1
Hua Li
University of California san francisco
Co-authored papers 1
Hussein A Tawbi
MD Anderson Cancer Center
Co-authored papers 1
Joshua Armenia
Oncology R&D
Co-authored papers 1
Lodewyk F A Wessels
University Medical Centre Mannheim, University of Heidelberg
Co-authored papers 1
Maria L Cortés
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Release 1.2