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Author Details

Grant W Brown
University of Toronto, 1 King's College Circle
1991
112
47
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37594077Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae.Genetics2023
35087094High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds.NPJ Syst Biol Appl2022
35587152Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG.G3 (Bethesda)2022
35434120Yeast goes viral: probing SARS-CoV-2 biology using <i>S. cerevisiae</i>.Microb Cell2022
35686905Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes.Genetics2022
35414135LSD1 is required for euchromatic origin firing and replication timing.Signal Transduct Target Ther2022
35894211Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation.Elife2022
34294749Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes.Sci Rep2021
35430602Author Correction: Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma.Nat Cancer2021
33853860Setting molecular traps in yeast for identification of anticancer drug targets.Proc Natl Acad Sci U S A2021
33529165RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.J Clin Invest2021
34871443VID22 counteracts G-quadruplex-induced genome instability.Nucleic Acids Res2021
34568909The amino acid substitution affects cellular response to mistranslation.G3 (Bethesda)2021
32265288A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in <i>Saccharomyces cerevisiae</i>.G3 (Bethesda)2020
35122047Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma.Nat Cancer2020
33082270Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in <i>Saccharomyces cerevisiae</i>.G3 (Bethesda)2020
32476470Mistranslating tRNA identifies a deleterious S213P mutation in the <i>Saccharomyces cerevisiae</i><i>eco1-1</i> allele.Biochem Cell Biol2020
30967400Exploiting DNA Replication Stress for Cancer Treatment.Cancer Res2019
31429594Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer.Crit Rev Biochem Mol Biol2019
31219035The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay.Elife2019
30733119Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates.Mol Cell2019
29043626DNA Replication Profiling Using Deep Sequencing.Methods Mol Biol2018
29807908Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.Mol Syst Biol2018
29875260The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.J Cell Biol2018
29674565Systematic analysis of complex genetic interactions.Science2018
29361465Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome.Cell Syst2018
29741650Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.Nucleic Acids Res2018
28759014Functional annotation of chemical libraries across diverse biological processes.Nat Chem Biol2017
28483909Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.Mol Cell Biol2017
28211448CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.Nat Commun2017
29161247Errata: Functional annotation of chemical libraries across diverse biological processes.Nat Chem Biol2017
29161244Errata: Functional annotation of chemical libraries across diverse biological processes.Nat Chem Biol2017
28916784P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance.Nat Commun2017
28839115Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in <i>Saccharomyces cerevisiae</i>.G3 (Bethesda)2017
26893079High-throughput fluorescence microscopic analysis of protein abundance and localization in budding yeast.Crit Rev Biochem Mol Biol2016
26490958Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Nucleic Acids Res2016
27617677Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.Cell Syst2016
27574117Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.Nucleic Acids Res2016
27373152Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.Cell Rep2016
26832692Single-Molecule Analysis of Replicating Yeast Chromosomes.Cold Spring Harb Protoc2016
26832684Analysis of Replicating Yeast Chromosomes by DNA Combing.Cold Spring Harb Protoc2016
26774285HELB Is a Feedback Inhibitor of DNA End Resection.Mol Cell2016
26920759MTE1 Functions with MPH1 in Double-Strand Break Repair.Genetics2016
25721128Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.G3 (Bethesda)2015
26362319Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase.Genetics2015
26163422Genetic Regulation of Dna2 Localization During the DNA Damage Response.G3 (Bethesda)2015
26113155Assembly of Slx4 signaling complexes behind DNA replication forks.EMBO J2015
25896509Dampening DNA damage checkpoint signalling via coordinated BRCT domain interactions.EMBO J2015
25843717E4F1 is a master regulator of CHK1-mediated functions.Cell Rep2015
25916702A high-throughput confocal fluorescence microscopy platform to study DNA replication stress in yeast cells.Methods Mol Biol2015
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Collaborators

Charles Boone
University of Toronto
Co-authored papers 29
David Gallo
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 13
Brenda J Andrews
University of Toronto
Co-authored papers 13
Michael Costanzo
Co-authored papers 11
Michael Chang
Columbia University Medical Center
Co-authored papers 9
Chad L Myers
University of Minnesota - Twin Cities
Co-authored papers 8
Zhaolei Zhang
University of Toronto
Co-authored papers 6
Hong Xu
British Columbia Cancer Research Centre
Co-authored papers 6
Tania Michelle Roberts
ETH Zurich
Co-authored papers 5
Huiming Ding
Massachusetts Institute of Technology
Co-authored papers 5
Marta B Davidson
University of Toronto
Co-authored papers 4
Marcus B Smolka
Weill Institute for Cell and Molecular Biology, Cornell University
Co-authored papers 4
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 4
Anna Y Lee
Ontario Institute for Cancer Research
Co-authored papers 4
Renee L Brost
Cubist Pharmaceuticals, Inc.
Co-authored papers 3
Gary D Bader
University of Toronto
Co-authored papers 3
Philip Hieter
University of British Columbia
Co-authored papers 3
Frederick P Roth
University of Toronto
Co-authored papers 3
Zhijian Li
University of Toronto
Co-authored papers 3
Marinella Gebbia
University of Toronto
Co-authored papers 3
Bilal N Sheikh
Helmholtz Institute for Metabolic
Co-authored papers 3
Hongwei Zhu
Peking Union Medical College Hospital
Co-authored papers 3
Ainslie B Parsons
University of Toronto
Co-authored papers 3
Jasper Rine
University of California berkeley
Co-authored papers 3
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 3
Justin Nelson
Co-authored papers 3
Lawrence E Heisler
Ontario Institute for Cancer Research
Co-authored papers 3
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 3
Yiqun Chen
University of Toronto, College Street
Co-authored papers 3
Timothy R Hughes
University of Toronto
Co-authored papers 3
Release 1.2