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Author Details

Carlota Lopez Cara
Department of Pharmaceutical and Organic Chemistry, University of Granada
2005
75
22
PMIDPaper TitleJournal TitlePublished Year
36493617New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action.Eur J Med Chem2023
35214160Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines.Pharmaceutics2022
35456549Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors.Pharmaceutics2022
342902433-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.Nat Commun2021
34575436Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors.Pharmaceutics2021
34834257New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity.Pharmaceutics2021
32977218Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism.Eur J Med Chem2020
31727470Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selective modulators (SAhRMs) versus rapidly metabolized ligands (RMAhRLs).Eur J Med Chem2020
30633509Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.J Med Chem2019
31408964Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy.Pharmaceutics2019
30911014Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells.Sci Rep2019
292207902-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.Eur J Med Chem2018
30043647Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors.Future Med Chem2018
298803991,2-Diphenoxiethane salts as potent antiplasmodial agents.Bioorg Med Chem Lett2018
30093861Enhancement of Tumor Cell Death by Combining <i>gef</i> Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells.Front Pharmacol2018
30006194EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.Biochem Pharmacol2018
30360374Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.Cancers (Basel)2018
29620429Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.J Enzyme Inhib Med Chem2018
28419928Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents.Eur J Med Chem2017
28406191Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.Sci Rep2017
27029499Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).Sci Rep2016
26629859Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation.Eur J Med Chem2016
27216165Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole.Sci Rep2016
27402422<sup>1</sup> H and <sup>13</sup> C NMR spectral assignments of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives.Magn Reson Chem2016
25785605Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin.J Med Chem2015
27490389Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1.Mol Inform2015
26141910Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.Eur J Med Chem2015
25875870New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.Future Med Chem2015
241704811H, 13C NMR studies of new 3-aminophenol isomers linked to pyridinium salts.Magn Reson Chem2014
25515750Choline kinase active site provides features for designing versatile inhibitors.Curr Top Med Chem2014
25181013Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.J Med Chem2014
24332652Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A⿁ adenosine receptor.Bioorg Med Chem2014
24398384Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.Bioorg Med Chem2014
23911855Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor.Eur J Med Chem2013
24080101New non-symmetrical choline kinase inhibitors.Bioorg Med Chem2013
24164557Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.J Med Chem2013
22182575Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A⿁ adenosine receptor.Bioorg Med Chem2012
23152402In silico pharmacology for a multidisciplinary drug discovery process.Drug Metabol Drug Interact2012
22693150NMR spectroscopic characterization of new 2,3-dihydro-1,3,4-thiadiazole derivatives.Magn Reson Chem2012
22889387Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.J Med Chem2012
22512552Melatonin synthetic analogs as nitric oxide synthase inhibitors.Mini Rev Med Chem2012
223363851,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.Eur J Med Chem2012
21126804New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.Eur J Med Chem2011
22027100One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.Eur J Med Chem2011
21805646Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis.ChemMedChem2011
20378350Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.Bioorg Med Chem Lett2010
20933308Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents.Eur J Med Chem2010
20676361Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells.Lett Drug Des Discov2010
20420439Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.J Med Chem2010
19250822Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.Bioorg Med Chem Lett2009
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Collaborators

Department of Pharmaceutical Sciences, University of Perugia
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University of Perugia
Co-authored papers 2
University of Perugia
Co-authored papers 2
University of Perugia
Co-authored papers 1
Englander Institute for Precision Medicine
Co-authored papers 1
Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa
Co-authored papers 1
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 1
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati"
Co-authored papers 1
Weill Cornell Medical College
Co-authored papers 1
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati"
Co-authored papers 1
Wihuri Research Institute
Co-authored papers 1
University of Colorado Anschutz Medical Campus
Co-authored papers 1
National Institute of Arthritis
Co-authored papers 1
Albert Einstein College of Medicine
Co-authored papers 1
Herbert Irving Comprehensive Cancer Center, Columbia University
Co-authored papers 1
University of Perugia
Co-authored papers 1
Weill Cornell School of Medicine
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Institute of Pharmaceutical Sciences, ETH Zurich
Co-authored papers 1
Weill Cornell Medical College
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Institute of Pharmaceutical Sciences, ETH Zurich
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University of Perugia
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Weill Cornell Medical College
Co-authored papers 1
Department of Pharmaceutical Sciences, University of Perugia
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New York Medical College
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University of Helsinki
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Montefiore Medical Center, Albert Einstein College of Medicine
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Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
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Albert Einstein College of Medicine
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Department of Pharmaceutical Sciences, University of Perugia
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