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Author Details

Ishan Deshpande
Department of Pharmaceutical Chemistry, University of California san francisco
2016
14
10
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37292845GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.bioRxiv2023
37196676Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.Nature2023
34562250Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody.Methods Mol Biol2022
33440172Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.Cell Host Microbe2021
33853786Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.Sci Adv2021
33490064EpCAM-Mediated Cellular Plasticity Promotes Radiation Resistance and Metastasis in Breast Cancer.Front Cell Dev Biol2021
32817938An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.bioRxiv2020
31894584The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin.EMBO J2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33154106An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.Science2020
31515872The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin.EMBO J2019
31263273Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.Nature2019
29033322Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage.Mol Cell2017
27889450RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.Mol Cell2016
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Collaborators

Aashish Manglik
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 6
Gregory E Merz
University of California san francisco
Co-authored papers 4
Susan M Gasser
L'Institut Suisse de Recherche Experimentale sur le Cancer (ISREC) Foundation
Co-authored papers 4
Huong T Kratochvil
Department of Pharmaceutical Chemistry, University of California-San Francisco
Co-authored papers 4
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 3
Kaitlin Schaefer
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Veronica V Rezelj
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 3
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 3
Alexandrea N Rizo
University of California san francisco
Co-authored papers 3
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 3
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Sergei Pourmal
University of California san francisco
Co-authored papers 3
Kaihua Zhang
Henan Normal University
Co-authored papers 3
Raphael Trenker
Cardiovascular Research Institute, University of California San Francisco
Co-authored papers 3
Un Seng Chio
University of California san francisco
Co-authored papers 3
Camille R Simoneau
Gladstone Institute of Virology
Co-authored papers 3
Cynthia M Chio
University of California san francisco
Co-authored papers 3
Meghna Gupta
University of California san francisco
Co-authored papers 3
Amber M Smith
University of California san francisco
Co-authored papers 3
Axel F Brilot
University of California san francisco
Co-authored papers 3
Smriti Sangwan
Howard Hughes Medical Institute, University of California los angeles
Co-authored papers 3
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 3
Kris M White
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 3
Cristina Puchades
University of California San Francisco (UCSF) School of Medicine
Co-authored papers 3
Caleigh M Azumaya
Fred Hutchinson Cancer Center
Co-authored papers 3
Christian B Billesb??lle
Department of Pharmaceutical Chemistry, University of California san francisco
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Henry C Nguyen
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Reuben A Saunders
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Release 1.2