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Author Details

Denis M Grant
University of Toronto
1983
92
45
PMIDPaper TitleJournal TitlePublished Year
36529140Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling.Cell Chem Biol2023
37509350Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity.Cancers (Basel)2023
36519841Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor.Toxicol Sci2023
35055106Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice.Int J Mol Sci2022
33475084Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets.Elife2021
341290492,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (TiparpH532A) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality.Toxicol Sci2021
32763287The impact of sex on hepatotoxic, inflammatory and proliferative responses in mouse models of liver carcinogenesis.Toxicology2020
33020065Cell Type-Specific Roles of CD38 in the Interactions of Isoniazid with NAD<sup>+</sup> in the Liver.Drug Metab Dispos2020
31075357Primary aromatic amines and cancer: Novel mechanistic insights using 4-aminobiphenyl as a model carcinogen.Pharmacol Ther2019
30883722A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.FEBS Lett2019
310833003-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (<i>Tiparp</i>) Knockout Mice.Int J Mol Sci2019
30373764Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity.Biochem J2018
29873790Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome.Toxicol Sci2018
28888949Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.Biochem Pharmacol2017
28277663Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy.J Med Chem2017
27746196Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.Toxicology2016
25601990N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.Toxicol Sci2015
26192006Caffeine Consumption Contributes to Skin Intrinsic Fluorescence in Type 1 Diabetes.Diabetes Technol Ther2015
25922528Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice.Drug Metab Dispos2015
25975270Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.J Biol Chem2015
24623063Paradoxical attenuation of autoimmune hepatitis by oral isoniazid in wild-type and N-acetyltransferase-deficient mice.Drug Metab Dispos2014
23861064Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.Development2013
242050295-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion.PLoS One2013
22193722Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice.Cancer Lett2012
22508569Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver.Environ Mol Mutagen2012
21317369Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.Drug Metab Dispos2011
19295529Pharmacogenetics of pharmacoecology: which route to personalized medicine?Clin Pharmacol Ther2009
20444014The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats.J Vet Pharmacol Ther2009
18334921Changes in consensus arylamine N-acetyltransferase gene nomenclature.Pharmacogenet Genomics2008
18680466Structures of human arylamine N-acetyltransferases.Curr Drug Metab2008
17403913Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.Drug Metab Dispos2007
17656365Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases.J Biol Chem2007
17339856The art and science of personalized medicine.Clin Pharmacol Ther2007
16815960In vivo and in vitro metabolism of arylamine procarcinogens in acetyltransferase-deficient mice.Drug Metab Dispos2006
15226670Pharmacogenetics and the regulation of gene transcription.Pharmacogenetics2004
15595973A simple test for acetylator phenotype using caffeine. 1984.Br J Clin Pharmacol2004
12815173Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.Mol Pharmacol2003
11207033Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects.Pharmacogenetics2001
11368758Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a cysteine protease catalytic domain and an active-site loop.Biochem J2001
10746928Localization of N-acetyltransferases NAT1 and NAT2 in human tissues.Toxicol Sci2000
10862519Update on consensus arylamine N-acetyltransferase gene nomenclature.Pharmacogenetics2000
10899814A SNPshot: pharmacogenetics and the future of drug therapy.Trends Biotechnol2000
10971207Pharmacogenetics of the human arylamine N-acetyltransferases.Pharmacology2000
11095579Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber.Drug Metab Dispos2000
10794727Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2.Biochem J2000
10495364Pharmacogenomics and the changing face of clinical pharmacology.Can J Clin Pharmacol1999
9682272Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas.Pharmacogenetics1998
9566732Novel sulfotransferases cloned by RT-PCR: real proteins or PCR artifacts?Chem Biol Interact1998
9511182Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe.Pharmacogenetics1998
9731717NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations.Pharmacogenetics1998
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1 Vanderbilt University Medical Center
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Collaborators

University of Toronto
Co-authored papers 19
Institute of Basic Medical Sciences, University of Oslo
Co-authored papers 10
Universite de Paris, CNRS
Co-authored papers 9
Universite Paris Cite, CNRS
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Leslie Dan Faculty of Pharmacy and Faculty of Medicine, University of Toronto
Co-authored papers 2
University of Lorraine
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
Institute of Human Genetics, University of Minnesota
Co-authored papers 1
Departments of Pharmaceutical Sciences.
Co-authored papers 1
Oregon Health and Science University
Co-authored papers 1
The Hospital for Sick Children
Co-authored papers 1
Shandong Jianzhu University
Co-authored papers 1
University of California los angeles
Co-authored papers 1
Ontario Tech University
Co-authored papers 1
INSERM UMR-S1124, Universite Paris Cite
Co-authored papers 1
Universite de Paris, CNRS
Co-authored papers 1
Universite de Paris, CNRS
Co-authored papers 1
Universite Paris Cite, CNRS
Co-authored papers 1
Co-authored papers 1
Universite de Paris, CNRS
Co-authored papers 1
University of Oslo
Co-authored papers 1
Oregon Health & Science University
Co-authored papers 1
University Health Network
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1