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Author Details

Xiaoguang Lei
Peking-Tsinghua Center for Life Sciences, Peking University
2003
139
32
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38095542Chemoproteomics, A Broad Avenue to Target Deconvolution.Adv Sci (Weinh)2024
36302896Structural basis of TRPV3 inhibition by an antagonist.Nat Chem Biol2023
37607402Investigation of Peptide Labeling with <i>ortho</i>-Phthalaldehyde and 2-Acylbenzaldehyde.J Org Chem2023
37772099Divergent total syntheses of ITHQ-type bis-β-carboline alkaloids by regio-selective formal aza-[4 + 2] cycloaddition and late-stage C-H functionalization.Chem Sci2023
37535747Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.Science2023
37252352Conformational Dynamics of the Activated GLP-1 Receptor-G<sub>s</sub> Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling.ACS Cent Sci2023
37396867C-H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors.ACS Cent Sci2023
36402026OSMAC strategy integrated with molecular networking discovery peniciacetals A-I, nine new meroterpenoids from the mangrove-derived fungus Penicillium sp. HLLG-122.Bioorg Chem2023
36929637Total Synthesis of Diverse Tetramic Acid Bearing cis-Decalin Natural Products.Angew Chem Int Ed Engl2023
35322515Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering.Angew Chem Int Ed Engl2022
35352470Testing the polar auxin transport model with a selective plasma membrane H<sup>+</sup> -ATPase inhibitor.J Integr Plant Biol2022
35677041A Novel <i>STAT3</i> Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease.Front Immunol2022
35395187A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration.Cell Stem Cell2022
35853282Perturbation of biological processes with small molecule kinase inhibitors.Curr Opin Chem Biol2022
35718680Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis.J Dermatol Sci2022
36590256Biomimetic Total Synthesis and the Biological Evaluation of Natural Product (-)-Fargesone A as a Novel FXR Agonist.JACS Au2022
36550107Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.Cell Discov2022
36601137Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins.Natl Sci Rev2022
36558100Natural Product 2-Oxokolavenol Is a Novel FXR Agonist.Molecules2022
36311099Screening of protonstatin-1 (PS-1) analogs for improved inhibitors of plant plasma membrane H<sup>+</sup>-ATPase activity.Front Plant Sci2022
36071685Bile acids regulate the epithelial Na<sup>+</sup> channel in native tissues through direct binding at multiple sites.J Physiol2022
36307403Structural mechanism of SGLT1 inhibitors.Nat Commun2022
36130198A Novel Gene Alignment in <i>Dorea</i> sp. AM58-8 Produces 7-Dehydroxy-3β Bile Acids from Primary Bile Acids.Biochemistry2022
36265550Subcellular Interactomes Revealed by Merging APEX with Cross-Linking Mass Spectrometry.Anal Chem2022
36049085Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria.ACS Chem Biol2022
35317609Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth.Circulation2022
35304446Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers.Nat Commun2022
33231344Biosynthetic Intermediate Probes for Visualizing and Identifying the Biosynthetic Enzymes of Plant Metabolites.Chembiochem2021
33792863Human Endogenous Natural Products.Prog Chem Org Nat Prod2021
34458817Click-based amplification: designed to facilitate various target labelling modes with ultralow background amplification.RSC Chem Biol2021
34339895Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H<sup>+</sup>-ATPase and Na<sup>+</sup>/H<sup>+</sup> antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.Mol Plant2021
33975691Corrigendum "Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry" [Analytica Chimica Acta 1102 (2020) 53-62].Anal Chim Acta2021
33288959Click-ExM enables expansion microscopy for all biomolecules.Nat Methods2021
33302045Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.Bioorg Med Chem2021
32451436FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis.Nat Chem2020
31968171Protecting-Group-Free Syntheses of <i>ent</i>-Kaurane Diterpenoids: [3+2+1] Cycloaddition/Cycloalkenylation Approach.J Am Chem Soc2020
31868281Biomimetic Synthesis of Rhytidenoneâ¿¿A and Mode of Action of Cytotoxic Rhytidenoneâ¿¿F.Angew Chem Int Ed Engl2020
32043996Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry.Anal Chim Acta2020
31918304Styryllactones from Goniothalamus tamirensis.Phytochemistry2020
33136373New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products.Acc Chem Res2020
32607440Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis.ACS Cent Sci2020
33002294Chemoenzymatic Total Syntheses of Artonin I with an Intermolecular Diels-Alderase.Biotechnol J2020
32802402Chemical screening identifies ROCK1 as a regulator of migrasome formation.Cell Discov2020
33021378Syntheses of Skeletally Diverse Tetracyclic <i>Isodon</i> Diterpenoid Scaffolds Guided by Dienyne Radical Cyclization Logic.Org Lett2020
32272078An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence.Cell Host Microbe2020
32297735Dissecting Programmed Cell Death with Small Molecules.Acc Chem Res2020
32135178Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis.J Hepatol2020
32490181Late-Stage Diversification of Natural Products.ACS Cent Sci2020
32255637Computation-Guided Development of the "Click" <i>ortho</i>-Quinone Methide Cycloaddition with Improved Kinetics.Org Lett2020
30418462Total synthesis of (±)-antroquinonol.Org Biomol Chem2019
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Collaborators

Meng-Qiu Dong
National Institute of Biological Sciences
Co-authored papers 7
Wenqing Shui
iHuman Institute, ShanghaiTech University
Co-authored papers 3
Yue-He Ding
Co-authored papers 2
Suwen Zhao
ShanghaiTech University, China iHuman Institute
Co-authored papers 2
Fan Wu
ShanghaiTech University
Co-authored papers 1
Bingjie Zhang
JiangYuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine
Co-authored papers 1
Zhiran Fan
Biocreater (WuHan) Biotechnology Co.
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Jill P Mesirov
University of California San Diego
Co-authored papers 1
Stuart L Schreiber
Broad Institute
Co-authored papers 1
Raymond T Chung
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 1
Kimberly L Cooper
University of California
Co-authored papers 1
Liping Sun
iHuman Institute, ShanghaiTech University
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Robert L Sah
University of California
Co-authored papers 1
Shijia Yuan
iHuman Institute, ShanghaiTech University
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Raymond C Stevens
iHuman Institute, ShanghaiTech University
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Scott D Rychnovsky
University of California irvine
Co-authored papers 1
Jun Qin
Co-authored papers 1
Frank J Gonzalez
Co-authored papers 1
Yang Bai
Co-authored papers 1
Chenxi Wang
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Lisha Xia
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Xinqi Gong
Co-authored papers 1
Jack E Dixon
University of California
Co-authored papers 1
Lukas Chavez
University of California San Diego
Co-authored papers 1
Chen Pan
Shanghai Advanced Research Institute, Chinese Academy of Science
Co-authored papers 1
Release 1.2