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Author Details

Michael W Young
The Rockefeller University
1974
113
62
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36467698Chronic sleep loss disrupts rhythmic gene expression in <i>Drosophila</i>.Front Physiol2022
34408325Chronic social isolation signals starvation and reduces sleep in Drosophila.Nature2021
31768006Molecular mechanisms and physiological importance of circadian rhythms.Nat Rev Mol Cell Biol2020
28893860Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.Cold Spring Harb Perspect Biol2018
30003624Time Travels: A 40-Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Nobel Lecture).Angew Chem Int Ed Engl2018
29581265Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.Proc Natl Acad Sci U S A2018
29611807CK1/Doubletime activity delays transcription activation in the circadian clock.Elife2018
29195067As Time Flew By.Cell2017
28388406Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.Cell2017
29098954Guidelines for Genome-Scale Analysis of Biological Rhythms.J Biol Rhythms2017
27013671miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila.J Neurosci2016
27551082Changes in active site histidine hydrogen bonding trigger cryptochrome activation.Proc Natl Acad Sci U S A2016
25662449Studying circadian rhythm and sleep using genetic screens in Drosophila.Methods Enzymol2015
26578788Temperature compensation and temperature sensation in the circadian clock.Proc Natl Acad Sci U S A2015
25674790Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.PLoS Genet2015
24905781Interactive features of proteins composing eukaryotic circadian clocks.Annu Rev Biochem2014
23518567Updated structure of Drosophila cryptochrome.Nature2013
24297896Flavin reduction activates Drosophila cryptochrome.Proc Natl Acad Sci U S A2013
23782472Application of an ex vivo cellular model of circadian variation for bipolar disorder research: a proof of concept study.Bipolar Disord2013
22461610Control of sleep by cyclin A and its regulator.Science2012
21659538Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein.J Biol Chem2011
22080955Structure of full-length Drosophila cryptochrome.Nature2011
22196332insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.Neuron2011
21907720Structure of an enclosed dimer formed by the Drosophila period protein.J Mol Biol2011
21515571A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein.Genetics2011
18258753Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.J Biol Rhythms2008
19109901The right period for a Siesta.Neuron2008
18666831Activating PER repressor through a DBT-directed phosphorylation switch.PLoS Biol2008
18591494The in(put)s and out(put)s of the Drosophila circadian clock.Ann N Y Acad Sci2008
17128262Post-translational enzyme activation in an animal via optimized conditional protein splicing.Nat Chem Biol2007
18419263A PER/TIM/DBT interval timer for Drosophila's circadian clock.Cold Spring Harb Symp Quant Biol2007
17660445The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock.J Biol Rhythms2007
17411344Integration of light and temperature in the regulation of circadian gene expression in Drosophila.PLoS Genet2007
16565745Control of daily transcript oscillations in Drosophila by light and the circadian clock.PLoS Genet2006
17094740Interplay of circadian clocks and metabolic rhythms.Annu Rev Genet2006
16410523PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock.Science2006
15817283Circadian rhythms. Preface.Methods Enzymol2005
15930393The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.J Neurosci2005
15817298Molecular and statistical tools for circadian transcript profiling.Methods Enzymol2005
14745022An ultradian clock shapes genome expression in yeast.Proc Natl Acad Sci U S A2004
15534317Posttranscriptional and posttranslational regulation of clock genes.J Biol Rhythms2004
12581523vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.Cell2003
14712927CK1 and GSK3 in the Drosophila and mammalian circadian clock.Novartis Found Symp2003
11799064kuzbanian-mediated cleavage of Drosophila Notch.Genes Dev2002
12495617Big ben rings in a lesson on biological clocks.Neuron2002
12452482Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.Ann Med2002
11504941A Drosophila PIAS homologue negatively regulates stat92E.Proc Natl Acad Sci U S A2001
11719206Circadian regulation of gene expression systems in the Drosophila head.Neuron2001
11533719Time zones: a comparative genetics of circadian clocks.Nat Rev Genet2001
11440719A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock.Cell2001
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Collaborators

Rockefeller University
Co-authored papers 5
Co-authored papers 5
Rockefeller University
Co-authored papers 4
Co-authored papers 2
Keck School of Medicine, University of Southern California
Co-authored papers 2
Geisel School of Medicine at Dartmouth
Co-authored papers 1
University of California san francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
University of Utah
Co-authored papers 1
Co-authored papers 1
Danforth Foundation
Co-authored papers 1
Institutes for Medical Psychology and for Occupational-
Co-authored papers 1
Simons Center for Systems Biology, Institute for Advanced Study
Co-authored papers 1
Co-authored papers 1
Weill Medical College of Cornell University
Co-authored papers 1
Geisel School of Medicine at Dartmouth
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
Memorial Sloan-Kettering Cancer Center
Co-authored papers 1
Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Robert Wood Johnson Medical School
Co-authored papers 1
Cornell University
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Beijing University of Chinese Medicine
Co-authored papers 1
University of Florida College of Medicine
Co-authored papers 1
The University of Florida
Co-authored papers 1
NewYork-Presbyterian/Weill Cornell Medical Center
Co-authored papers 1
Geisel School of Medicine at Dartmouth
Co-authored papers 1