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Author Details
Full Name
Michael W Young
Affiliation
The Rockefeller University
ORCID
Career Start Year
1974
Papers
113
H Index
62
Expertise
CM4AI Collaborator
Andrej Sali (CM4AI)
PMID
Paper Title
Journal Title
Published Year
36467698
Chronic sleep loss disrupts rhythmic gene expression in <i>Drosophila</i>.
Front Physiol
2022
34408325
Chronic social isolation signals starvation and reduces sleep in Drosophila.
Nature
2021
31768006
Molecular mechanisms and physiological importance of circadian rhythms.
Nat Rev Mol Cell Biol
2020
28893860
Coordination between Differentially Regulated Circadian Clocks Generates Rhythmic Behavior.
Cold Spring Harb Perspect Biol
2018
30003624
Time Travels: A 40-Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Nobel Lecture).
Angew Chem Int Ed Engl
2018
29581265
Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.
Proc Natl Acad Sci U S A
2018
29611807
CK1/Doubletime activity delays transcription activation in the circadian clock.
Elife
2018
29195067
As Time Flew By.
Cell
2017
28388406
Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.
Cell
2017
29098954
Guidelines for Genome-Scale Analysis of Biological Rhythms.
J Biol Rhythms
2017
27013671
miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila.
J Neurosci
2016
27551082
Changes in active site histidine hydrogen bonding trigger cryptochrome activation.
Proc Natl Acad Sci U S A
2016
25662449
Studying circadian rhythm and sleep using genetic screens in Drosophila.
Methods Enzymol
2015
26578788
Temperature compensation and temperature sensation in the circadian clock.
Proc Natl Acad Sci U S A
2015
25674790
Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
PLoS Genet
2015
24905781
Interactive features of proteins composing eukaryotic circadian clocks.
Annu Rev Biochem
2014
23518567
Updated structure of Drosophila cryptochrome.
Nature
2013
24297896
Flavin reduction activates Drosophila cryptochrome.
Proc Natl Acad Sci U S A
2013
23782472
Application of an ex vivo cellular model of circadian variation for bipolar disorder research: a proof of concept study.
Bipolar Disord
2013
22461610
Control of sleep by cyclin A and its regulator.
Science
2012
21659538
Kinetics of doubletime kinase-dependent degradation of the Drosophila period protein.
J Biol Chem
2011
22080955
Structure of full-length Drosophila cryptochrome.
Nature
2011
22196332
insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.
Neuron
2011
21907720
Structure of an enclosed dimer formed by the Drosophila period protein.
J Mol Biol
2011
21515571
A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein.
Genetics
2011
18258753
Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.
J Biol Rhythms
2008
19109901
The right period for a Siesta.
Neuron
2008
18666831
Activating PER repressor through a DBT-directed phosphorylation switch.
PLoS Biol
2008
18591494
The in(put)s and out(put)s of the Drosophila circadian clock.
Ann N Y Acad Sci
2008
17128262
Post-translational enzyme activation in an animal via optimized conditional protein splicing.
Nat Chem Biol
2007
18419263
A PER/TIM/DBT interval timer for Drosophila's circadian clock.
Cold Spring Harb Symp Quant Biol
2007
17660445
The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock.
J Biol Rhythms
2007
17411344
Integration of light and temperature in the regulation of circadian gene expression in Drosophila.
PLoS Genet
2007
16565745
Control of daily transcript oscillations in Drosophila by light and the circadian clock.
PLoS Genet
2006
17094740
Interplay of circadian clocks and metabolic rhythms.
Annu Rev Genet
2006
16410523
PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock.
Science
2006
15817283
Circadian rhythms. Preface.
Methods Enzymol
2005
15930393
The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.
J Neurosci
2005
15817298
Molecular and statistical tools for circadian transcript profiling.
Methods Enzymol
2005
14745022
An ultradian clock shapes genome expression in yeast.
Proc Natl Acad Sci U S A
2004
15534317
Posttranscriptional and posttranslational regulation of clock genes.
J Biol Rhythms
2004
12581523
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.
Cell
2003
14712927
CK1 and GSK3 in the Drosophila and mammalian circadian clock.
Novartis Found Symp
2003
11799064
kuzbanian-mediated cleavage of Drosophila Notch.
Genes Dev
2002
12495617
Big ben rings in a lesson on biological clocks.
Neuron
2002
12452482
Molecular genetics of timing in intrinsic circadian rhythm sleep disorders.
Ann Med
2002
11504941
A Drosophila PIAS homologue negatively regulates stat92E.
Proc Natl Acad Sci U S A
2001
11719206
Circadian regulation of gene expression systems in the Drosophila head.
Neuron
2001
11533719
Time zones: a comparative genetics of circadian clocks.
Nat Rev Genet
2001
11440719
A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock.
Cell
2001
1 - 50 of 113
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row(s) 1 - 30 of 30
Collaborators
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Rockefeller University
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S Martinek
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Co-authored papers
4
Michael Rosbash
Co-authored papers
2
Steve A Kay
Keck School of Medicine, University of Southern California
Co-authored papers
2
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Geisel School of Medicine at Dartmouth
Co-authored papers
1
Gregory E Merz
University of California san francisco
Co-authored papers
1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers
1
Mark Yandell
University of Utah
Co-authored papers
1
Eric C Lai
Co-authored papers
1
Todd C Mockler
Danforth Foundation
Co-authored papers
1
Till Roenneberg
Institutes for Medical Psychology and for Occupational-
Co-authored papers
1
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Simons Center for Systems Biology, Institute for Advanced Study
Co-authored papers
1
Peter Robin Hiesinger
Co-authored papers
1
Nebojsa Mirkovic
Weill Medical College of Cornell University
Co-authored papers
1
Jay C Dunlap
Geisel School of Medicine at Dartmouth
Co-authored papers
1
Jennifer R Wortman
Broad Institute of MIT and Harvard
Co-authored papers
1
Woo S Joo
Memorial Sloan-Kettering Cancer Center
Co-authored papers
1
Nikola P Pavletich
Memorial Sloan Kettering Cancer Center
Co-authored papers
1
Vishwajit L Nimgaonkar
Co-authored papers
1
Garret A FitzGerald
Perelman School of Medicine, University of Pennsylvania
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1
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Robert Wood Johnson Medical School
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Lois Pollack
Cornell University
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