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Author Details
Full Name
Andrew E Aplin
Affiliation
Thomas Jefferson University
ORCID
Career Start Year
1996
Papers
162
H Index
49
Expertise
CM4AI Collaborator
Prashant Mali (CM4AI)
PMID
Paper Title
Journal Title
Published Year
37847239
SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death.
Mol Cancer Res
2024
36223548
IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression.
Mol Cancer Ther
2023
37636077
Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas.
iScience
2023
37543514
Targeting TEAD-ious resistance.
Trends Cancer
2023
37605008
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.
Nat Cell Biol
2023
37343247
Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma.
Mol Cancer Ther
2023
37444561
Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth.
Cancers (Basel)
2023
37331825
Site matters in metastatic melanoma.
Trends Cancer
2023
36795483
Lysosomal lipid peroxidation regulates tumor immunity.
J Clin Invest
2023
36598655
Engaging community members in cancer research: an assessment of an NCI-designated cancer center.
Cancer Causes Control
2023
35296667
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.
Nat Commun
2022
35652219
Packing a Punch against PD-L1.
Cancer Discov
2022
35426938
Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma.
Mol Cancer Res
2022
35657206
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma.
Cancer Res
2022
35513054
The future of targeted kinase inhibitors in melanoma.
Pharmacol Ther
2022
36044013
Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma.
Mol Cancer Res
2022
36230787
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Cancers (Basel)
2022
35046531
Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.
Oncogene
2022
35147163
RAS-mediated tumor stress adaptation and the targeting opportunities it presents.
Dis Model Mech
2022
35086548
Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway.
J Exp Clin Cancer Res
2022
33000894
Role of serine 365 in BRAF V600E sensitivity to RAF inhibition.
Pigment Cell Melanoma Res
2021
33545064
Melanoma models for the next generation of therapies.
Cancer Cell
2021
33568347
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.
Clin Cancer Res
2021
33510355
Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
Oncogene
2021
33806615
Dual Targeting of CDK4/6 and cMET in Metastatic Uveal Melanoma.
Cancers (Basel)
2021
35121999
PROactively TACkling CDK4/6 therapy resistance.
Nat Cancer
2021
34879275
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects.
Cell Rep
2021
34479970
From the Community to the Bench and Back Again: The Value of Patient and Community Engagement in Cancer Research.
Cancer Discov
2021
34389658
Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for <i>GNAQ</i>-Driven Uveal Melanoma.
Clin Cancer Res
2021
34127435
Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.
Trends Cancer
2021
33060121
The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019).
Clin Cancer Res
2021
33452215
Combined SHPments: An Effective Therapeutic Strategy for MPNST.
Cancer Res
2021
33451983
Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy.
Cancer Discov
2021
33446574
Roles of the BAP1 Tumor Suppressor in Cell Metabolism.
Cancer Res
2021
33208912
BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.
Oncogene
2021
32430489
Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma.
Mol Cancer Ther
2020
31932756
Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma.
Br J Cancer
2020
31696640
PLX3397 inhibits the accumulation of intra-tumoral macrophages and improves bromodomain and extra-terminal inhibitor efficacy in melanoma.
Pigment Cell Melanoma Res
2020
31796433
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis.
Cancer Discov
2020
31940493
FOXD3 Regulates VISTA Expression in Melanoma.
Cell Rep
2020
33037411
S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.
Oncogene
2020
32661093
Activation of CD8<sup>+</sup> T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors.
Cancer Immunol Res
2020
32389536
Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition.
J Invest Dermatol
2020
30610113
Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma.
EMBO Mol Med
2019
31270153
<i>In Vivo</i> ERK1/2 Reporter Predictively Models Response and Resistance to Combined BRAF and MEK Inhibitors in Melanoma.
Mol Cancer Ther
2019
31239444
m<sup>6</sup>A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Nat Commun
2019
31375579
Murine Cytomegalovirus Infection of Melanoma Lesions Delays Tumor Growth by Recruiting and Repolarizing Monocytic Phagocytes in the Tumor.
J Virol
2019
31251472
C57BL/6 congenic mouse NRAS<sup>Q61K</sup> melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo.
Pigment Cell Melanoma Res
2019
31063649
The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
Pigment Cell Melanoma Res
2019
30703359
BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
J Invest Dermatol
2019
1 - 50 of 162
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Collaborators
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Phil F Cheng
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Co-authored papers
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Ashani T Weeraratna
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Co-authored papers
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David W Speicher
Co-authored papers
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Katherine L Nathanson
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Co-authored papers
3
Jeffrey E Gershenwald
The University of Texas MD Anderson Cancer Center
Co-authored papers
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Chi-Ping Day
Center for Cancer Research, National Cancer Institute
Co-authored papers
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Georgina V Long
Co-authored papers
3
Rong Hu
Co-authored papers
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Lawrence N Kwong
The University of Texas MD Anderson Cancer Center
Co-authored papers
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Jennifer A Wargo
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Gaurav Kumar
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Jonathan A Pachter
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