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Author Details

Khai Phan
2011
18
13
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34435786Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A<sub>3</sub> Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.J Med Chem2021
24456490Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.J Med Chem2014
25116377Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.J Am Chem Soc2014
23179047Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.Purinergic Signal2013
22175234Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.Bioconjug Chem2012
23185482Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonists.PLoS One2012
23342198Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.ACS Med Chem Lett2012
23145215Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.ACS Med Chem Lett2012
22921089Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.J Med Chem2012
22486652Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.J Med Chem2012
22559880Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.J Med Chem2012
22402302Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.Biochem Pharmacol2012
22142423Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting Aâ¿¿A and Aâ¿¿ adenosine receptor ligands.J Med Chem2012
22104008Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound Aâ¿¿A adenosine receptor.J Med Chem2012
22154845Anti-ischemic effects of multivalent dendrimeric Aâ¿¿ adenosine receptor agonists in cultured cardiomyocytes and in the isolated rat heart.Pharmacol Res2012
21185184Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.Bioorg Med Chem Lett2011
21858244Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element.ACS Med Chem Lett2011
21860878Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.Org Biomol Chem2011
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Collaborators

Kenneth A Jacobson
National Institutes of Health
Co-authored papers 18
Zhan-Guo Gao
National Institutes of Health
Co-authored papers 17
Steven M Moss
University of California San Francisco
Co-authored papers 4
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Adam C Marko
Co-authored papers 1
Peter Kolb
Institut fur Pharmazeutische Chemie, Philipps-Universitat Marburg
Co-authored papers 1
John A Auchampach
Co-authored papers 1
Jens Carlsson
Uppsala University
Co-authored papers 1
Ruben Abagyan
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 1
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