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Author Details

George Stamatoyannopoulos
University of Washington
1962
374
65
Nathan Sheffield (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34477013Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy.Hum Gene Ther2021
31192450Genetic history of the population of Crete.Ann Hum Genet2019
29789357Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing.Blood2018
27987208Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in patients with β-thalassemia major.Transfusion2017
28272534Genetics of the peloponnesean populations and the theory of extinction of the medieval peloponnesean Greeks.Eur J Hum Genet2017
28783727Genetic origins of the Minoans and Mycenaeans.Nature2017
28024082Evidence for the in vivo safety of insulated foamy viral vectors.Gene Ther2017
27654912The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.Nature2016
25580597Genomic discovery of potent chromatin insulators for human gene therapy.Nat Biotechnol2015
26322838Functional footprinting of regulatory DNA.Nat Methods2015
26143582An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Exp Hematol2015
26089395Plerixafor+G-CSF-mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy.Blood2015
25910277Functional validation of a constitutive autonomous silencer element.PLoS One2015
24927591Maritime route of colonization of Europe.Proc Natl Acad Sci U S A2014
25333506Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model.Hum Gene Ther Methods2014
23673646A European population in Minoan Bronze Age Crete.Nat Commun2013
23985037Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors.BMC Genomics2013
24001178Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.Hum Gene Ther2013
21981728Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.Hum Gene Ther2012
22955617The accessible chromatin landscape of the human genome.Nature2012
22000492A search for β thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans.Blood Cells Mol Dis2012
21908035Thalassaemia.Lancet2012
21952171Hematopoietic stem cell mobilization for gene therapy of adult patients with severe β-thalassemia: results of clinical trials using G-CSF or plerixafor in splenectomized and nonsplenectomized subjects.Mol Ther2012
19914848Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.Blood Cells Mol Dis2010
20712773Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease.Ann N Y Acad Sci2010
20883576Gene therapy for β-thalassaemia: the continuing challenge.Expert Rev Mol Med2010
20195264The birth of the American Society of Gene Therapy.Mol Ther2010
19240697Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Mol Ther2009
19781549The higher structure of chromatin in the LCR of the beta-globin locus changes during development.J Mol Biol2009
18177253Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region.Hum Gene Ther2008
17212360Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching.J Cell Biochem2007
17588470MicroRNA expression dynamics during murine and human erythroid differentiation.Exp Hematol2007
17881636Histone acetylation at the human beta-globin locus changes with developmental age.Blood2007
17411365Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.Hum Gene Ther2007
17056066Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.J Mol Biol2007
17114178Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter.J Biol Chem2007
17131378The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis.J Cell Biochem2007
17224162Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.J Mol Biol2007
16647882Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.Mol Ther2006
16803575Effects of human gamma-globin in murine beta-thalassaemia.Br J Haematol2006
16782867Autonomous silencing as well as competition controls gamma-globin gene expression during development.Mol Cell Biol2006
16888791Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.Am J Hematol2006
16914453Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.Nucleic Acids Res2006
16514181Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.Exp Biol Med (Maywood)2006
15479724Butyrate increases the efficiency of translation of gamma-globin mRNA.Blood2005
16199858Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.Mol Cell Biol2005
16188685Prospects for developing a molecular cure for thalassemia.Hematology2005
16155112Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.Hum Mol Genet2005
16216538Investigations of the induction of the goat beta(C) globin gene by erythropoietin: studies in transgenic mice.Blood Cells Mol Dis2005
16338486Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo.Exp Hematol2005
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Collaborators

Patrick A Navas
University of Washington
Co-authored papers 19
Arno G Motulsky
University of Washington
Co-authored papers 15
John A Stamatoyannopoulos
Altius Institute for Biomedical Sciences
Co-authored papers 10
Carl Anthony Blau
Center for Cancer Innovation, University of Washington
Co-authored papers 9
Hua Cao
Co-authored papers 7
Man Yu
Co-authored papers 6
Dimitra M Lotakis
University of Michigan, C.S. Mott Children's Hospital, 1540 E. Hospital Dr. ann arbor
Co-authored papers 3
Stuart H Orkin
Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School
Co-authored papers 3
Kathleen A Leppig
Kaiser Permanente Washington
Co-authored papers 2
Peter J Sabo
University of Washington
Co-authored papers 2
Kathy K Niakan
The Francis Crick Institute
Co-authored papers 2
David Reich
Co-authored papers 2
Pavel Sova
Altius Institute for Biomedical Sciences
Co-authored papers 2
Richard Sandstrom
Altius Institute for Biomedical Sciences
Co-authored papers 2
Peter S Rabinovitch
Co-authored papers 2
Nick Patterson
Harvard University
Co-authored papers 2
Wendy H Raskind
University of Washington School of Medicine
Co-authored papers 2
Mark Matsushita
University of Washington
Co-authored papers 2
David M Bodine
Co-authored papers 2
Hongzhu Qu
University of Chinese Academy of Sciences
Co-authored papers 2
Michael O Dorschner
University of Washington
Co-authored papers 2
Matthew T Maurano
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 2
Jeff Vierstra
Altius Institute for Biomedical Sciences
Co-authored papers 2
Richard Humbert
University of Washington
Co-authored papers 2
Antonio Cao
Co-authored papers 2
Bum-Kyu Lee
Cancer Research Center, University at Albany, State University of New York
Co-authored papers 1
Robert E Thurman
University of Washington
Co-authored papers 1
Job Dekker
University of Massachusetts Chan Medical School
Co-authored papers 1
Kristen Lee
Altius Institute for Biomedical Sciences
Co-authored papers 1
Lingyun Song
Center for Genomic & Computational Biology, Duke University
Co-authored papers 1
Release 1.2