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Author Details

Chang-En Yu
and Clinical Center
1989
101
45
PMIDPaper TitleJournal TitlePublished Year
37445616<i>APOE</i> Locus-Associated Mitochondrial Function and Its Implication in Alzheimer's Disease and Aging.Int J Mol Sci2023
37628615Weight Loss Is a Strong Predictor of Memory Disorder Independent of Genetic Influences.Genes (Basel)2023
37220618A Preliminary Comparison of the Methylome and Transcriptome from the Prefrontal Cortex Across Alzheimer's Disease and Lewy Body Dementia.J Alzheimers Dis Rep2023
37452081Crosstalk between KIF1C and PRKAR1A in left atrial myxoma.Commun Biol2023
35186005Case Report: A Novel Homozygous Mutation in <i>MYF5</i> Due to Paternal Uniparental Isodisomy of Chromosome 12 in a Case of External Ophthalmoplegia With Rib and Vertebral Anomalies.Front Genet2022
35964003TOMM40 genetic variants associated with healthy aging and longevity: a systematic review.BMC Geriatr2022
34204109<i>TOMM40</i> RNA Transcription in Alzheimer's Disease Brain and Its Implication in Mitochondrial Dysfunction.Genes (Basel)2021
34899847Novel Partial Exon 51 Deletion in the Duchenne Muscular Dystrophy Gene Identified <i>via</i> Whole Exome Sequencing and Long-Read Whole-Genome Sequencing.Front Genet2021
32750315Evolution of a Human-Specific Tandem Repeat Associated with ALS.Am J Hum Genet2020
31978088Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.PLoS One2020
33090224Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry.JAMA Netw Open2020
32977230Lack of APOE Christchurch variant in five age of onset outliers with PSEN1, PSEN2 Alzheimer's disease and MAPT frontotemporal dementia.J Neurol Sci2020
30820047Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.Nat Genet2019
29045054Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.Genes Brain Behav2018
30081037Glia-specific APOE epigenetic changes in the Alzheimer's disease brain.Brain Res2018
29544979APOE DNA methylation is altered in Lewy body dementia.Alzheimers Dement2018
29371683DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease.J Hum Genet2018
28714976Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.Nat Genet2017
28673336Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults.Alzheimers Res Ther2017
25531812Rarity of the Alzheimer disease-protective APP A673T variant in the United States.JAMA Neurol2015
26402071The APOE Gene is Differentially Methylated in Alzheimer's Disease.J Alzheimers Dis2015
26136306Erratum to: Epigenetic considerations of the APOE gene.Biomol Concepts2015
26076170R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.JAMA Neurol2015
26083568Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease.J Neuropathol Exp Neurol2015
25808939Cerebrospinal fluid Aβ42 levels and APP processing pathway genes in Parkinson's disease.Mov Disord2015
25741792Epigenetic considerations of the APOE gene. [corrected].Biomol Concepts2015
24011543Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects.Neurobiol Aging2014
25199842Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.JAMA Neurol2014
25048271Influence of lifestyle modifications on age-related free radical injury to brain.JAMA Neurol2014
24756381Cross-sectional and longitudinal relationships between cerebrospinal fluid biomarkers and cognitive function in people without cognitive impairment from across the adult life span.JAMA Neurol2014
24495933Clinical and molecular studies reveal a PSEN1 mutation (L153V) in a Peruvian family with early-onset Alzheimer's disease.Neurosci Lett2014
23183136TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ε3/ε3.Alzheimers Dement2013
23822153MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma.Biomarkers2013
23892237Epigenetic signature and enhancer activity of the human APOE gene.Hum Mol Genet2013
22114258Differential expression of the glutamate transporter GLT-1 in pancreas.J Histochem Cytochem2012
22927204Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease.Am J Med Genet B Neuropsychiatr Genet2012
22869155Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.Arch Neurol2012
22628073Inheritance model introduces differential bias in CNV calls between parents and offspring.Genet Epidemiol2012
22572541ADAM10 expression and promoter haplotype in Alzheimer's disease.Neurobiol Aging2012
22089642Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.J Hum Genet2012
20385245Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms.Neuroimage2011
21685912Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Nat Genet2011
21438139Mutations in the TSGA14 gene in families with autism spectrum disorders.Am J Med Genet B Neuropsychiatr Genet2011
21196064Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.Neurobiol Aging2011
19554612APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.Am J Med Genet B Neuropsychiatr Genet2010
21045163Genetics of Alzheimer disease.J Geriatr Psychiatry Neurol2010
21209939The effect of algorithms on copy number variant detection.PLoS One2010
20457965The N141I mutation in PSEN2: implications for the quintessential case of Alzheimer disease.Arch Neurol2010
20142524The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.Arch Neurol2010
20333730Evidence for three loci modifying age-at-onset of Alzheimer's disease in early-onset PSEN2 families.Am J Med Genet B Neuropsychiatr Genet2010
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UCSF Weill Institute for Neurosciences, University of California san francisco
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Swedish Neuroscience Institute
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Massachusetts General Hospital
Co-authored papers 5
Columbia University Irving Medical Center, New York Presbyterian Hospital
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Northwestern University Feinberg School of Medicine
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