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Author Details

Sachdev S Sidhu
School of Pharmacy, University of Waterloo
1993
279
67
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37295821Generation and Selection of Synthetic Human Antibody Libraries via Phage Display.Cold Spring Harb Protoc2024
37945533Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.Protein Sci2024
37295822Beyond Natural Immune Repertoires: Synthetic Antibodies.Cold Spring Harb Protoc2024
37321220Targeted alveolar regeneration with Frizzled-specific agonists.Cell2023
37668982Engineering SH2 Domains with Tailored Specificities and Affinities.Methods Mol Biol2023
37917586Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids.Cell Rep2023
37904046Structural surfaceomics reveals an AML-specific conformation of integrin β<sub>2</sub> as a CAR T cellular therapy target.Nat Cancer2023
37653169Activity-based profiling of cullin-RING E3 networks by conformation-specific probes.Nat Chem Biol2023
37932852Cell-based passive immunization for protection against SARS-CoV-2 infection.Stem Cell Res Ther2023
38040684Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.Nat Commun2023
37679615Construction of Synthetic Antibody Phage Display Libraries.Methods Mol Biol2023
35106377Rapid On-Cell Selection of High-Performance Human Antibodies.ACS Cent Sci2022
35806342A Quantitative Assay for Ca<sup>2+</sup> Uptake through Normal and Pathological Hemichannels.Int J Mol Sci2022
35481650Synthetic antibodies block receptor binding and current-inhibiting effects of α-cobratoxin from Naja kaouthia.Protein Sci2022
35613471Engineered SH2 Domains for Targeted Phosphoproteomics.ACS Chem Biol2022
35406799Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids.Cells2022
35405107Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins.J Mol Biol2022
35796308A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells.ACS Chem Biol2022
35789908Monoclonal antibodies binding data for SARS-CoV-2 proteins.Data Brief2022
35385646Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs.ACS Chem Biol2022
36548304Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.PLoS Pathog2022
36459484Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation.Elife2022
36333470Antigenic mapping reveals sites of vulnerability on α-HCoV spike protein.Commun Biol2022
35277930A Descriptor Set for Quantitative Structure-property Relationship Prediction in Biologics.Mol Inform2022
34190031A T cell redirection platform for co-targeting dual antigens on solid tumors.MAbs2021
33910979SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.Sci Transl Med2021
33621466A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.ACS Chem Biol2021
33846513Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.Commun Biol2021
33646117Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism.Elife2021
33536174Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress.J Virol2021
34857742Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.Nat Commun2021
34666042A Panel of Engineered Ubiquitin Variants Targeting the Family of Domains Found in Ubiquitin Specific Proteases (DUSPs).J Mol Biol2021
34665194USP10 Promotes Fibronectin Recycling, Secretion, and Organization.Invest Ophthalmol Vis Sci2021
34397214Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k.ACS Chem Biol2021
34508727Systematic Engineering of Optimized Autonomous Heavy-Chain Variable Domains.J Mol Biol2021
34452531Peptide Platform as a Powerful Tool in the Fight against COVID-19.Viruses2021
34559985Lrp1 is a host entry factor for Rift Valley fever virus.Cell2021
34105895A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.EMBO Mol Med2021
33961407Site-Specific Conjugation of Metal-Chelating Polymers to Anti-Frizzled-2 Antibodies <i>via</i> Microbial Transglutaminase.Biomacromolecules2021
33980972CellectSeq: In silico discovery of antibodies targeting integral membrane proteins combining in situ selections and next-generation sequencing.Commun Biol2021
34090922Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins.J Mol Biol2021
34171344Comprehensive Assessment of the Relationship Between Site<sup>-2</sup> Specificity and Helix α2 in the Erbin PDZ Domain.J Mol Biol2021
34329642Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.J Mol Biol2021
32511401Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.bioRxiv2020
31905227Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding.PLoS Pathog2020
31634471Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes.J Mol Biol2020
31954129A Synthetic Human Antibody Antagonizes IL-18Rβ Signaling Through an Allosteric Mechanism.J Mol Biol2020
31980006<i>In situ</i> antibody phage display yields optimal inhibitors of integrin α11/β1.MAbs2020
31654425Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.Protein Sci2020
33398270Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.bioRxiv2020
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Collaborators

Jason Moffat
University of Toronto
Co-authored papers 23
Gary D Bader
University of Toronto
Co-authored papers 12
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 11
Gaya K Amarasinghe
Washington University School of Medicine at St. Louis
Co-authored papers 10
Raffi Tonikian
Merck & Co., Inc.
Co-authored papers 10
Charles Boone
University of Toronto
Co-authored papers 8
Kevin R Brown
College Street, University of Toronto
Co-authored papers 7
James A Wells
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 7
Daisy W Leung
Washington University School of Medicine
Co-authored papers 7
Shawn S-C Li
University of Western Ontario
Co-authored papers 6
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 5
Rita E Chen
Co-authored papers 5
Jiefei Tong
Hospital for Sick Children
Co-authored papers 5
Jinrong Min
Central China Normal University
Co-authored papers 5
Michael F Moran
Hospital for Sick Children, University of Toronto
Co-authored papers 5
Michael S Diamond
Washington University School of Medicine
Co-authored papers 5
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 4
Traver Hart
University of Texas MD Anderson Cancer Center
Co-authored papers 4
J. Wade Harper
Harvard Medical School
Co-authored papers 3
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 3
Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 3
Zhijian Li
University of Toronto
Co-authored papers 3
Xiaofeng Xin
Massachusetts Institute of Technology
Co-authored papers 3
Michael L Gross
Washington University in St. Louis
Co-authored papers 3
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 3
Siyuan Ding
Washington University School of Medicine
Co-authored papers 3
Yufeng Tong
University of Windsor
Co-authored papers 3
Elitza S Theel
Division of Clinical Microbiology, Mayo Clinic
Co-authored papers 3
Tony Pawson
Co-authored papers 3
Mark Gerstein
Yale University
Co-authored papers 3
Release 1.2