Author details

Full Name

Iain D C Fraser

Affiliation

ORCID

Career Start Year

1991

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36624264	Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis.		2023
37202395	Identification of age-specific gene regulators of La Crosse virus neuroinvasion and pathogenesis.	Nat Commun	2023
36280745	Author Correction: Commensal-driven immune zonation of the liver promotes host defence.	Nature	2022
36179680	Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection.	Cell Rep	2022
35961990	Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways.	Sci Data	2022
35764396	High-throughput imaging of mRNA at the single-cell level in human primary immune cells.	RNA	2022
34373651	Author Correction: Commensal-driven immune zonation of the liver promotes host defence.	Nature	2021
33684179	Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol.	PLoS Pathogens	2021
33894945	SIGNAL: A web-based iterative analysis platform integrating pathway and network approaches optimizes hit selection from genome-scale assays.		2021
34347853	Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol.	PLoS Pathogens	2021
34344832	A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.	Sci Signal	2021
34342534	Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics.	mSystems	2021
34334306	Lipid regulation of NLRP3 inflammasome activity through organelle stress.	Trends in Immunology	2021
34082753	Age influences susceptibility of brain capillary endothelial cells to La Crosse virus infection and cell death.	Journal of Neuroinflammation	2021
33239787	Commensal-driven immune zonation of the liver promotes host defence.	Nature	2021
34859120	Lentivirus-mediated Conditional Gene Expression.	Bio Protoc	2021
33293463	A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses.	Sci Signal	2020
33782652	Single-tube genotyping for small insertion/deletion mutations: simultaneous identification of wild type, mutant and heterozygous alleles.	Biology Methods and Protocols	2020
32529831	Dynamic ADP-Ribosylome, Phosphoproteome, and Interactome in LPS-Activated Macrophages.	J Proteome Res	2020
33141508	A Deep Learning Pipeline for Nucleus Segmentation.	Cytometry. Part A : the journal of the International Society for Analytical Cytology	2020
31148944	The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages.	Mediators of Inflammation	2019
31024544	NF-ÎºB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration.	Frontiers in Immunology	2019
30857388	Multi-Omics Strategies Uncover Host-Pathogen Interactions.	ACS Infect Dis	2019
31011167	U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.	Nat Cell Biol	2019
31385572	IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses.	Elife	2019
30674564	Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.	J Exp Med	2019
29177856	Measurement of NF-ÎºB Activation in TLR-Activated Macrophages.	Methods in Molecular Biology	2018
30196390	3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism.	Digestive Diseases and Sciences	2018
29949751	Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin.	J Mol Biol	2018
30282041	IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages.	Cell Rep	2018
29898962	Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression.	J Immunol	2018
28235783	Proteome and Secretome Analysis Reveals Differential Post-transcriptional Regulation of Toll-like Receptor Responses.	Molecular and Cellular Proteomics	2017
28469251	Lipopolysaccharide-induced NF-ÎºB nuclear translocation is primarily dependent on MyD88, but TNFÎ± expression requires TRIF and MyD88.	Scientific Reports	2017
28641113	Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.	Neuron	2017
28801231	Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action.	Immunity	2017
28750197	Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages.	Cell Systems	2017
28248930	Genome-wide siRNA screen of genes regulating the LPS-induced TNF-Î± response in human macrophages.	Scientific data	2017
28248925	Genome-wide siRNA screen of genes regulating the LPS-induced NF-ÎºB and TNF-Î± responses in mouse macrophages.	Scientific data	2017
26667172	Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.	Journal of Immunology	2016
27237739	Distinct NF-ÎºB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.	Cell Syst	2016
26799652	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).	Autophagy	2016
26732763	Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.	Sci Signal	2016
26997126	Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.	Nat Commun	2016
26505731	Assay Development for Image-Based Quantification of Intracellular Bacterial Replication and Analysis of the Innate Immune Response to Infection.	Assay and Drug Development Technologies	2015
25831078	Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophages.	Sci Rep	2015
24425788	Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-ÎºB signaling.	Sci Signal	2014
24119232	Burkholderia cenocepaciaâ¿¿J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.	Cell Microbiol	2014
23708291	Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.	Nat Med	2013
22247330	Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.	FASEB J	2012
22952450	Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection.	PLoS Pathog	2012