Author details

Full Name

Mark Chaffin

Affiliation

ORCID

Career Start Year

2014

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36790929	Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.	Cell Rep	2023
38014050	Transcriptional profile of the rat cardiovascular system at single cell resolution.	bioRxiv	2023
37550580	Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender.	Nat Methods	2023
36959364	Adjusting for common variant polygenic scores improves yield in rare variant association analyses.	Nat Genet	2023
37019578	The Genetic Determinants of AorticÂ Distention.	J Am Coll Cardiol	2023
37258680	Transfer learning enables predictions in network biology.	Nature	2023
36865094	Plasma extracellular vesicle transcriptome as a dynamic liquid biopsy in acute heart failure.	medRxiv	2023
34849650	Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.	Cardiovasc Res	2022
36048760	Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.	PLoS Genet	2022
36172868	Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.	Arterioscler Thromb Vasc Biol	2022
35732739	Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.	Nature	2022
34750571	Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.	Nat Metab	2021
33822779	Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.	PLoS Genet	2021
33654293	Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.	Nat Med	2021
34319147	Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.	Circ Genom Precis Med	2021
34663679	SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.	Life Sci Alliance	2021
35128489	Vascular smooth muscle cell phenotype switching in carotid atherosclerosis.	JVS Vasc Sci	2021
34480422	The genomics of heart failure: design and rationale of the HERMES consortium.	ESC Heart Fail	2021
32498804	Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.	J Am Coll Cardiol	2020
31699787	Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease.	Haematologica	2020
31691645	Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results From a National Biobank.	Circ Res	2020
32248749	Identification of Functional Variant Enhancers Associated With Atrial Fibrillation.	Circ Res	2020
32403949	Transcriptional and Cellular Diversity of the Human Heart.	Circulation	2020
32164899	Titin Truncating Variants in Adults Without Known Congestive HeartÂ Failure.	J Am Coll Cardiol	2020
32439900	Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.	Nat Commun	2020
32382064	Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.	Nat Commun	2020
33155827	Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation.	Circ Genom Precis Med	2020
32762905	Validation of a Genome-Wide PolygenicÂ Score for Coronary ArteryÂ Disease inÂ South Asians.	J Am Coll Cardiol	2020
32804569	Genetic Variation in Cardiometabolic Traits and Medication Targets and the Risk of Hypertensive Disorders of Pregnancy.	Circulation	2020
32795091	Myocyte-Specific Upregulation of <i>ACE2</i> in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis.	Circulation	2020
32511660	Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis.	medRxiv	2020
32957805	Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.	Arterioscler Thromb Vasc Biol	2020
31549875	Response by Aragam et al to Letter Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery".	Circulation	2019
31558144	Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI.	Stroke	2019
30586733	Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.	Circulation	2019
30389748	DNA Sequence Variation in <i>ACVR1C</i> Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.	Diabetes	2019
30562035	MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment.	J Proteome Res	2019
31285632	Genome-wide association study of peripheral artery disease in the Million Veteran Program.	Nat Med	2019
31002795	Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.	Cell	2019
29785011	A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.	Nat Genet	2018
29892015	Multi-ethnic genome-wide association study for atrial fibrillation.	Nat Genet	2018
29973585	Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.	Nat Commun	2018
30104762	Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.	Nat Genet	2018
30390058	Author Correction: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.	Nat Genet	2018
30535219	Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.	JAMA	2018
30140049	Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.	Nat Commun	2018
30140000	Deep-coverage whole genome sequences and blood lipids among 16,324 individuals.	Nat Commun	2018
30275531	Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.	Nat Genet	2018
29691411	Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.	Nat Commun	2018
29237688	Heritability of Atrial Fibrillation.	Circ Cardiovasc Genet	2017