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Author Details

Yi-Liang Liu
National Chung Hsing University
1988
45
21
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37217557Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration.Commun Biol2023
35019151Ornithine decarboxylase functions in both autophagy and apoptosis in response to ultraviolet B radiation injury.J Cell Physiol2022
35101449Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2.J Biol Chem2022
35236296Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism.Cell Mol Biol Lett2022
33436675Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.Sci Rep2021
33554057Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)<sup>+</sup>-dependent malic enzyme.iScience2021
33432662Regulation of polyamine homeostasis through an antizyme citrullination pathway.J Cell Physiol2021
33348871Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase.Nutrients2020
31842334Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase.Biomolecules2019
30166453CRL4<sup>AMBRA1</sup> targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.EMBO J2018
28546558Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4.Sci Rep2017
28209966Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4.Sci Rep2017
27457559Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.ChemMedChem2016
27564465Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase.Biochemistry2016
25815158Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries.ACS Med Chem Lett2015
24492373Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy.Antimicrob Agents Chemother2014
25411474A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.Sci Transl Med2014
24999381Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.Chem Sci2014
25140796Functional roles of the dimer-interface residues in human ornithine decarboxylase.PLoS One2014
24789335Squalene synthase as a target for Chagas disease therapeutics.PLoS Pathog2014
24927548Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.Proc Natl Acad Sci U S A2014
24568559Multitarget drug discovery for tuberculosis and other infectious diseases.J Med Chem2014
23322418Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus.Chembiochem2013
23610597Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.ACS Med Chem Lett2013
23421555Farnesyl diphosphate synthase inhibitors from in silico screening.Chem Biol Drug Des2013
23382808Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4.PLoS One2013
23248302Antibacterial drug leads targeting isoprenoid biosynthesis.Proc Natl Acad Sci U S A2013
22392982Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.Proc Natl Acad Sci U S A2012
22486710Head-to-head prenyl tranferases: anti-infective drug targets.J Med Chem2012
22586085Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins.Proc Natl Acad Sci U S A2012
22662288HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.ACS Med Chem Lett2012
22290830Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.ChemMedChem2012
21480428Reduction of graphene oxide by aniline with its concomitant oxidative polymerization.Macromol Rapid Commun2011
22073206Determinants of the differential antizyme-binding affinity of ornithine decarboxylase.PLoS One2011
21805510Nonvolatile rewritable memory effects in graphene oxide functionalized by conjugated polymer containing fluorene and carbazole units.Chemistry2011
21552531Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor.PLoS One2011
21731701Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4).PLoS One2011
20173096Bioorganometallic mechanism of action, and inhibition, of IspH.Proc Natl Acad Sci U S A2010
21098670Mechanism of action and inhibition of dehydrosqualene synthase.Proc Natl Acad Sci U S A2010
19456099Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.J Med Chem2009
16084398Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.Protein Expr Purif2005
16135565Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.Proc Natl Acad Sci U S A2005
12788066Reversible folding of cysteine-rich metallothionein by an overcritical reaction path.Biochem Biophys Res Commun2003
1680553Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.Cancer Res1991
3130679Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat.Toxicol Appl Pharmacol1988
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Collaborators

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Co-authored papers 4
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Emory University
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
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Northwestern University Feinberg School of Medicine
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
California Institute of Technology
Co-authored papers 1
West China Hospital, Sichuan University
Co-authored papers 1
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
University of Toronto
Co-authored papers 1
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Co-authored papers 1
Fred Hutchinson Cancer Center
Co-authored papers 1
University of Chicago
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Co-authored papers 1