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Author Details

Or Gozani
Stanford University
1994
120
59
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37094697Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation.J Biol Chem2023
37790557Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis.bioRxiv2023
37788669Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement.Cell2023
37684554Functional epigenomics: chromatin complexity untangled.Nat Struct Mol Biol2023
37311054Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.Cancer Res2023
37209825The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation.J Biol Chem2023
36075902Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.Nat Commun2022
36417913Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation.Mol Cell2022
33469207Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease.Nat Rev Drug Discov2021
33536620Elevated NSD3 histone methylation activity drives squamous cell lung cancer.Nature2021
34555356NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis.Mol Cell2021
33941880Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype.Genet Med2021
33941775DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.Nat Commun2021
34017121Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation.Nat Immunol2021
34143967Chemical linguistics: Reading the modified proteome.Mol Cell2021
33361816Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.Nature2021
32442403SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy.Cancer Cell2020
31802103Cardioinformatics: the nexus of bioinformatics and precision cardiology.Brief Bioinform2020
31911441An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation.J Biol Chem2020
33060621Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation.Sci Rep2020
32675241Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.Proc Natl Acad Sci U S A2020
32611769Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.J Biol Chem2020
30612740METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.Cell2019
31388018Structural basis for the target specificity of actin histidine methyltransferase SETD3.Nat Commun2019
31527793Enterovirus pathogenesis requires the host methyltransferase SETD3.Nat Microbiol2019
31582846Histone lysine methyltransferases in biology and disease.Nat Struct Mol Biol2019
31294639HeartBioPortal.Circ Genom Precis Med2019
31578417Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.Sci Rep2019
30626964SETD3 is an actin histidine methyltransferase that prevents primary dystocia.Nature2019
27732873Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation.J Mol Biol2017
28241142Cancer epigenetics: Reading the future of leukaemia.Nature2017
28623961Histone modifications for chromatin dynamics and cellular plasticity.J Mol Biol2017
28933651Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells.Epigenetics2017
28655759RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.J Biol Chem2017
26876097Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette.Structure2016
30713830Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase.Transl Cancer Res2016
26598646Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.Mol Cell Proteomics2016
27693255Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.Neuron2016
27580749Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.Cold Spring Harb Perspect Med2016
27154821ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.Cancer Discov2016
26988419Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.Genes Dev2016
26912663A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.J Biol Chem2016
25795785A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.J Biol Chem2015
26439302The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.Mol Cell2015
25689043A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association.ACS Chem Biol2015
24442241Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.Epigenetics2014
25128496A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.Genes Dev2014
24805349Emerging technologies to map the protein methylome.J Mol Biol2014
24847881SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.Nature2014
24950375Nuclear PI5P, Uhrf1, and the road not taken.Mol Cell2014
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Collaborators

Alex J Kuo
Co-authored papers 15
Joshua E Elias
Addenbrooke's Hospital, University of Cambridge
Co-authored papers 11
Alex W Wilkinson
Stanford University
Co-authored papers 11
Peggie Cheung
Co-authored papers 11
Dinshaw J Patel
Memorial Sloan-Kettering Cancer Center
Co-authored papers 8
Benjamin A Garcia
University of Pennsylvania
Co-authored papers 8
Gloria Mas
Sylvester Comprehensive Cancer Center and.
Co-authored papers 7
Erin M Green
University of Maryland Baltimore County
Co-authored papers 7
Julien Sage
Department of Pediatrics Stanford University Stanford California USA.
Co-authored papers 7
Paul J Utz
Co-authored papers 7
Brian D Strahl
University of North Carolina
Co-authored papers 4
Glenn D Prestwich
Co-authored papers 4
Ettore Appella
Co-authored papers 4
Lewis C Cantley
Co-authored papers 4
Purvesh Khatri
University of California San Francisco
Co-authored papers 3
Natasha M Flores
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Howard Y Chang
Center for Personal Dynamic Regulomes, Stanford University
Co-authored papers 3
Jan E Carette
Stanford University School of Medicine
Co-authored papers 3
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 3
Jason S Lee
QIMR Berghofer Medical Research Institute
Co-authored papers 2
Jacques C??t??
Centre Hospitalier Universitaire (CHU) de Quebec-Universite Laval Research Center
Co-authored papers 2
Michael C Bassik
Stanford University Medical Center
Co-authored papers 2
Ashby J Morrison
Stanford University
Co-authored papers 2
Hiroshi Yamaguchi
Co-authored papers 2
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 2
Yaw Shin Ooi
Duke-NUS Medical School
Co-authored papers 2
Nicolas L Young
Baylor College of Medicine, USA Center for Precision Environmental Health
Co-authored papers 2
Jiewei Xu
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 2
Kyle M Miller
The University of Texas at Austin
Co-authored papers 2
Daehee Hwang
Co-authored papers 2
Release 1.2