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Author Details

Hiten D Madhani
University of California san francisco
1986
109
43
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37985333Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens.Trends Microbiol2024
37402368Targeted high-throughput mutagenesis of the human spliceosome reveals its in vivo operating principles.Mol Cell2023
37478821Meet the authors: Irene Beusch and Hiten Madhani.Mol Cell2023
37217653Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity.Nat Struct Mol Biol2023
37279752Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system.Immunity2023
34791226Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging.Genetics2022
36180247Christine Guthrie (1945-2022): a tribute from her trainees.RNA2022
35896747Secreted fungal virulence effector triggers allergic inflammation via TLR4.Nature2022
36323314Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.Cell Host Microbe2022
35918419Telomere transposon takeover in Cryptococcus.Nat Microbiol2022
35202575Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.Mol Cell2022
33092902Unbelievable but True: Epigenetics and Chromatin in Fungi.Trends Genet2021
35231122Model organism databases are in jeopardy.Development2021
34555349Coupling of spliceosome complexity to intron diversity.Curr Biol2021
34006103Re-emerging Aspartic Protease Targets: Examining <i>Cryptococcus neoformans</i> Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.J Med Chem2021
32514065Cholesterol in quarantine.Nat Immunol2020
32084344Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.Cell2020
32020195Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom.Nucleic Acids Res2020
31955845Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.Cell2020
32956370Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans.PLoS Genet2020
32437639ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.Mol Cell2020
31092606A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast <i>Cryptococcus neoformans</i>.G3 (Bethesda)2019
31226107A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.PLoS Biol2019
29235574Ten principles of heterochromatin formation and function.Nat Rev Mol Cell Biol2018
29967291Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.Genes Dev2018
30037883Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.Biol Open2018
30340045Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control.Cell2018
29423847Total RNA Isolation and Quantification of Specific RNAs in Fission Yeast.Methods Mol Biol2018
29727661Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution.Cell2018
29608794Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.Mol Microbiol2018
27212659Intracellular Action of a Secreted Peptide Required for Fungal Virulence.Cell Host Microbe2016
27977806Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.PLoS Pathog2016
27479698Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.PLoS One2016
27402158Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.Nucleic Acids Res2016
25533783Product binding enforces the genomic specificity of a yeast polycomb repressive complex.Cell2015
26275773Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans.Nucleic Acids Res2015
25968466Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.Nat Commun2015
25957277Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe.G3 (Bethesda)2015
24280023Recognizing the enemy within: licensing RNA-guided genome defense.Trends Biochem Sci2014
25416953Unraveling the biology of a fungal meningitis pathogen using chemical genetics.Cell2014
25377143Functional profiling of human fungal pathogen genomes.Cold Spring Harb Perspect Med2014
24520056Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.mBio2014
23485968A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.Nature2013
24315092snRNA catalysts in the spliceosome's ancient core.Cell2013
24418889The spliceosome as a transposon sensor.RNA Biol2013
24209615The frustrated gene: origins of eukaryotic gene expression.Cell2013
23849629Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.Mol Cell2013
24013500A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism.Genes Dev2013
23415457Stalled spliceosomes are a signal for RNAi-mediated genome defense.Cell2013
22688965Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.EMBO Rep2012
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Collaborators

John R Yates
TheScripps Research Institute
Co-authored papers 13
Geeta J Narlikar
University of California san francisco
Co-authored papers 9
Christine Guthrie
University of California san francisco
Co-authored papers 6
Christina M Homer
University of California san francisco
Co-authored papers 6
Sigurd Braun
Biomedical Center, Ludwig-Maximilians-Universitat of Munich
Co-authored papers 6
Caitlin I Stoddard
Fred Hutchinson Cancer Center.
Co-authored papers 3
Paul D Hartley
University of Nevada
Co-authored papers 3
Changbin Chen
Arizona State University
Co-authored papers 3
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Sean R Collins
University of California davis
Co-authored papers 2
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Starlynn C Clarke
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Amy Hin Yan Tong
University of Toronto
Co-authored papers 2
Jonathan K Pritchard
Co-authored papers 2
Harold Pimentel
Co-authored papers 2
Kevan M Shokat
University of California San Francisco
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Greg T Cantin
Amgen Inc.
Co-authored papers 2
Stuart L Schreiber
Broad Institute
Co-authored papers 1
Robert J Nichols
Stanford University
Co-authored papers 1
Barbara Panning
University of California san francisco
Co-authored papers 1
Tyler Jacks
Co-authored papers 1
Dinshaw J Patel
Memorial Sloan-Kettering Cancer Center
Co-authored papers 1
Leah E Cowen
University of Toronto
Co-authored papers 1
Jasper Rine
University of California berkeley
Co-authored papers 1
Jacob Stewart-Ornstein
Hillman Cancer Center, University of Pittsburgh School of Medicine
Co-authored papers 1
Shenping Wu
Yale University
Co-authored papers 1
Anthony J O'Donoghue
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 1
Michael Jason de la Cruz
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Justin Nelson
Co-authored papers 1
Release 1.2