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Author Details

Aravind Subramanian
1996
60
40
PMIDPaper TitleJournal TitlePublished Year
36563689Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.Stem Cell Reports2023
34877817Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network-based Cellular Signatures drug discovery platform.CPT Pharmacometrics Syst Pharmacol2022
36207580A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.Commun Biol2022
34535664A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.Nat Commun2021
33854057Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.Nat Commun2021
32558393Whole-blood dysregulation of actin-cytoskeleton pathway in adult spinal muscular atrophy patients.Ann Clin Transl Neurol2020
32613204Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.Nat Cancer2020
31202891Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).Mol Cell Neurosci2019
31560691Advancing computational biology and bioinformatics research through open innovation competitions.PLoS One2019
30203022The GCTx format and cmap{Py, R, M, J} packages: resources for optimized storage and integrated traversal of annotated dense matrices.2019
30964323The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity.Environ Health Perspect2019
29199020The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.Cell Syst2018
30552330Drug and disease signature integration identifies synergistic combinations in glioblastoma.Nat Commun2018
29915188GeNets: a unified web platform for network-based genomic analyses.Nat Methods2018
29655704A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.Cell Syst2018
29190685Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map.PLoS Biol2017
28558729High-throughput validation of ceRNA regulatory networks.BMC Genomics2017
28388612The Drug Repurposing Hub: a next-generation drug library and information resource.Nat Med2017
28837809Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.Cell Syst2017
29084964Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.Nat Commun2017
29195078A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.Cell2017
29232558High-throughput Phenotyping of Lung Cancer Somatic Mutations.Cancer Cell2017
27960085Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.Cancer Cell2016
27147599Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.Cancer Discov2016
26873929Gene expression inference with deep learning.2016
26912667Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes.Mol Cell Proteomics2016
27478040High-throughput Phenotyping of Lung Cancer Somatic Mutations.Cancer Cell2016
25811180Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.PLoS One2015
25089360An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.ACS Chem Biol2014
25512530Genetic modifiers of EGFR dependence in non-small cell lung cancer.Proc Natl Acad Sci U S A2014
24906883LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.Nucleic Acids Res2014
25024206Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Proc Natl Acad Sci U S A2014
24518066Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS).J Biomol Screen2014
23869022Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.Science2013
21546393Molecular signatures database (MSigDB) 3.0.Bioinformatics2011
21241896Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Cell2011
21183721Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.Proc Natl Acad Sci U S A2011
21496265SNP-based pathway enrichment analysis for genome-wide association studies.BMC Bioinformatics2011
21555567Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.Proc Natl Acad Sci U S A2011
20395368Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.Genes Dev2010
20972333Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.J Clin Invest2010
19318631Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.J Natl Cancer Inst2009
19267539A radiation-derived gene expression signature predicts clinical outcome for breast cancer patients.Radiation Research2009
18492802Perturbational profiling of nanomaterial biologic activity.Proc Natl Acad Sci U S A2008
19091943Highly parallel identification of essential genes in cancer cells.Proc Natl Acad Sci U S A2008
18505921Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases.Mol Cancer Res2008
17234754IFN-alpha-stimulated genes and Epstein-Barr virus gene expression distinguish WHO type II and III nasopharyngeal carcinomas.Cancer Res2007
17644558GSEA-P: a desktop application for Gene Set Enrichment Analysis.Bioinformatics2007
16707458Microarray-assisted pathway analysis identifies mitogen-activated protein kinase signaling as a mediator of resistance to the green tea polyphenol epigallocatechin 3-gallate in her-2/neu-overexpressing breast cancer cells.Cancer Research2006
17008526The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Science2006
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Broad Institute of Harvard and MIT
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Vanderbilt-Ingram Cancer Center, Vanderbilt University
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