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Author Details

Dominic C H Ng
2000
75
27
PMIDPaper TitleJournal TitlePublished Year
37056379MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases.Cell Rep Methods2023
37979178Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S.2023
35468848Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease.Acta Neuropathol Commun2022
34710087Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.PLoS Genetics2021
34169068TDP-43 Mutation Affects Stress Granule Dynamics in Differentiated NSC-34 Motoneuron-Like Cells.Front Cell Dev Biol2021
34059773WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.Communications Biology2021
33937237Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases.Frontiers in Cell and Developmental Biology2021
34502512Cilia, Centrosomes and Skeletal Muscle.International Journal of Molecular Sciences2021
32946803Centrosome Reduction Promotes Terminal Differentiation of Human Cardiomyocytes.Stem Cell Reports2020
32246948Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC.Biochimica et Biophysica Acta - Molecular Cell Research2020
31816041The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.Human Molecular Genetics2020
33042990The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus.Frontiers in Cell and Developmental Biology2020
30979500Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association.Biochemical and Biophysical Research Communications2019
30625347Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments.Biochimica et Biophysica Acta - Molecular Cell Research2019
29317621Integrated omics dissection of proteome dynamics during cardiac remodeling.Nat Commun2018
28940170The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.Molecular Neurobiology2018
30009778Quantitative temporal analysis of protein dynamics in cardiac remodeling.J Mol Cell Cardiol2018
30141336Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy.J Proteome Res2018
30566428MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.PLoS Biology2018
29484176Factors that influence adult neurogenesis as potential therapy.Translational Neurodegeneration2018
29589528Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases.Curr Med Chem2018
29407107Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2.International Journal of Cardiology2018
27321182Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.Oncogene2017
28690640WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells.2017
28625535Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth.Stem Cell Reports2017
28701724Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus.Scientific Reports2017
27980500Cardiovascular proteomics in the era of big data: experimental and computational advances.Clin Proteomics2016
26977904A large dataset of protein dynamics in the mammalian heart proteome.Sci Data2016
27356587Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems.J Proteome Res2016
26899498A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies.Pharmacol Ther2016
26713495Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.Cell Cycle2016
25820159Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.Eur J Pharmacol2015
25501809Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.Journal of Cell Science2015
25539453Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart.International Journal of Cardiology2015
25451123Dual role of Src kinase in governing neuronal survival.Brain Research2015
25824152Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma.Molecular Cancer Research2015
24957502Lysine ubiquitination and acetylation of human cardiac 20S proteasomes.Proteomics Clin Appl2014
24302736cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.Journal of Biological Chemistry2014
24184208Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress.2014
24589734Differences in c-Jun N-terminal kinase recognition and phosphorylation of closely related stathmin-family members.Biochemical and Biophysical Research Communications2014
24946186Characterization of human plasma proteome dynamics using deuterium oxide.Proteomics Clin Appl2014
24614109Protein kinetic signatures of the remodeling heart following isoproterenol stimulation.J Clin Invest2014
23410953Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.2013
24032640Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.Biochem J2013
23400779A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.Journal of Biological Chemistry2013
23592116Laser-induced dissociation of singly protonated peptides at 193 and 266 nm within a hybrid linear ion trap mass spectrometer.Rapid Communications in Mass Spectrometry2013
22899712WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression.Journal of Cell Science2012
22799634Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.Biochemical Journal2012
22426490Tracking protein aggregation and mislocalization in cells with flow cytometry.Nat Methods2012
22671034Arginine-facilitated isomerization: radical-induced dissociation of aliphatic radical cationic glycylarginyl(iso)leucine tripeptides.Journal of Physical Chemistry B2012
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