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Author Details

Jonathan B Johnston
Department of Pharmaceutical Chemistry, University of California san francisco
2007
22
18
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34289431Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1.Bioorg Med Chem2021
31442422The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.Mol Cell2019
28636604Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.Nature2017
28591576Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.Cell Rep2017
27528681Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.Proc Natl Acad Sci U S A2016
25768284Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase.PLoS Negl Trop Dis2015
251018014-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.J Med Chem2014
25393646Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.J Med Chem2014
23400640Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Beilstein J Org Chem2013
21983973Photosystem I from plants as a bacterial cytochrome P450 surrogate electron donor: terminal hydroxylation of branched hydrocarbon chains.Biotechnol Lett2012
22860142Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.PLoS Negl Trop Dis2012
22647881Substrate analog studies of the Ï¿-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.Bioorg Med Chem2012
20727847Structural control of cytochrome P450-catalyzed Ï¿-hydroxylation.Arch Biochem Biophys2011
21924910Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.Trends Microbiol2011
21315684Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans.Arch Biochem Biophys2011
19635450The Mycobacterium tuberculosis cytochrome P450 system.Arch Biochem Biophys2010
20843794Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.J Biol Chem2010
20545858Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.Mol Microbiol2010
20385875A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.Antimicrob Agents Chemother2010
19933331Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis.Proc Natl Acad Sci U S A2009
18345677Type II isopentenyl diphosphate isomerase: irreversible inactivation by covalent modification of flavin.J Am Chem Soc2008
17547410Type-2 isopentenyl diphosphate isomerase. Mechanistic studies with cyclopropyl and epoxy analogues.J Am Chem Soc2007
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Collaborators

James H McKerrow
Sandler Center for Drug Discovery, University of California San Francisco
Co-authored papers 6
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 6
C. Dale Poulter
University of Utah
Co-authored papers 2
Michael J Trnka
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 2
Linda Yen
Middlemore Hospital
Co-authored papers 2
Geeta J Narlikar
University of California san francisco
Co-authored papers 2
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Caitlin I Stoddard
Fred Hutchinson Cancer Center.
Co-authored papers 1
Dinshaw J Patel
Memorial Sloan-Kettering Cancer Center
Co-authored papers 1
David A Agard
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 1
Amander T Clark
Center for Reproductive Science, University of California los angeles
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Eugene Palovcak
University of California San Francisco
Co-authored papers 1
Jack Taunton
University of California san francisco
Co-authored papers 1
Coral Y Zhou
University of California berkeley
Co-authored papers 1
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 1
Jeffery S Cox
University of California berkeley
Co-authored papers 1
Juan A Oses-Prieto
Co-authored papers 1
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Release 1.2