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Author Details

John D Scott
University of Washington
1982
258
95
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36177749Phosphorylation, compartmentalization, and cardiac function.IUBMB Life2023
37425703Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.bioRxiv2023
37306403Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI.Biochem J2023
36692000Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.Elife2023
36607814Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells.STAR Protoc2023
35286684Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes.Methods Mol Biol2022
35830806Mislocalization of protein kinase A drives pathology in Cushing's syndrome.Cell Rep2022
32628872Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option.Annu Rev Pharmacol Toxicol2021
33909027Kinase-anchoring proteins in ciliary signal transduction.Biochem J2021
34618572Edmond Fischer (1920-2021).Science2021
34143863Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention.Biochem J2021
34256050Beyond PKA: Evolutionary and structural insights that define a docking and dimerization domain superfamily.J Biol Chem2021
32482893A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface.J Biol Chem2020
33082339AKAP5 complex facilitates purinergic modulation of vascular L-type Ca[2+] channel CaV1.2.Nat Commun2020
33082006AKAP Signaling Islands: Venues for Precision Pharmacology.Trends Pharmacol Sci2020
32732289Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles.J Biol Chem2020
30598507Depletion of dAKAP1-protein kinase A signaling islands from the outer mitochondrial membrane alters breast cancer cell metabolism and motility.J Biol Chem2019
31872801Subcellular drug targeting illuminates local kinase action.Elife2019
31781123CG-NAP/Kinase Interactions Fine-Tune T Cell Functions.Front Immunol2019
31063128An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.Elife2019
29440558Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca<sup>2+</sup>-Permeable AMPA Receptors.J Neurosci2018
30455320Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.Proc Natl Acad Sci U S A2018
29773583Protein kinase A activation: Something new under the sun?J Cell Biol2018
27856611Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.Cardiovasc Res2017
28408477Pseudoscaffolds and anchoring proteins: the difference is in the details.Biochem Soc Trans2017
28119464Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.Sci Signal2017
28967377Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.Elife2017
28642438Local protein kinase A action proceeds through intact holoenzymes.Science2017
26945093Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.J Biol Chem2016
27911714Regulation of the phosphatase PP2B by protein-protein interactions.Biochem Soc Trans2016
27481708Second Messengers.Cold Spring Harb Perspect Biol2016
27325686ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme.Mol Cancer Ther2016
27382054Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.J Biol Chem2016
27286827Bacterial spore coat protein kinases: A new twist to an old story.Proc Natl Acad Sci U S A2016
27402760AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption.Proc Natl Acad Sci U S A2016
27487922Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state.Acta Crystallogr F Struct Biol Commun2016
26687711Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.Gene2016
26990031Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.Pediatr Blood Cancer2016
27027723Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.Pediatr Res2016
26724383AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.Cell Signal2016
25783883Selective disruption of the AKAP signaling complexes.Methods Mol Biol2015
26406118A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.Elife2015
26283967Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder.Front Pharmacol2015
26088133Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220.J Biol Chem2015
25882844A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.J Biol Chem2015
25670860Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.J Biol Chem2015
25765284PKA-type I selective constrained peptide disruptors of AKAP complexes.ACS Chem Biol2015
25785716Signalling scaffolds and local organization of cellular behaviour.Nat Rev Mol Cell Biol2015
24446487E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.EMBO J2014
25005230AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.Sci Signal2014
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Collaborators

Iain D C Fraser
Co-authored papers 11
Tony Pawson
Co-authored papers 9
Alexandra C Newton
Co-authored papers 8
William A Catterall
Co-authored papers 6
Susan S Taylor
University of California
Co-authored papers 5
Rigney E Turnham
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 5
Raymond S Yeung
University of Washington
Co-authored papers 4
Heidi L Kenerson
University of Washington
Co-authored papers 4
Kimberly J Riehle
University of Washington
Co-authored papers 4
Jacob Raber
Oregon Health & Science University
Co-authored papers 3
James E Bruce
Co-authored papers 3
Chad R Weisbrod
Florida State University
Co-authored papers 3
John D Gordan
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 2
Mark F Bear
Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 2
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 2
Robert J Lefkowitz
Co-authored papers 2
David Veesler
Co-authored papers 2
Mark H Ellisman
National Center for Microscopy and Imaging Research, University of California
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Lily Jun-Shen Huang
University of Texas Southwestern Medical Center
Co-authored papers 2
Yeonjoo C Hwang
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 1
Rebecca R B Wolber
Quantitative Biosciences Institute (QBI), University of California San Francisco
Co-authored papers 1
Nabeel Bardeesy
Massachusetts General Hospital
Co-authored papers 1
Angus C Nairn
Co-authored papers 1
Phuong Vu
Harvard Medical School
Co-authored papers 1
Florian Stengel
University of Konstanz Universitatsstrasse 10
Co-authored papers 1
Devin K Schweppe
Co-authored papers 1
Christopher Dirk Keene
University of Washington
Co-authored papers 1
Donald M Bers
Co-authored papers 1
Trisha N Davis
University of Washington
Co-authored papers 1
Alice Y Ting
Stanford University
Co-authored papers 1
Release 1.2