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Author Details

Jens Meiler
Vanderbilt University
1954
392
59
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37873426Benchmarking AlphaMissense Pathogenicity Predictions Against Cystic Fibrosis Variants.bioRxiv2024
37662415Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants.bioRxiv2024
37978799Dark nanodiscs for evaluating membrane protein thermostability by differential scanning fluorimetry.Biophys J2024
36352786Template-free prediction of a new monotopic membrane protein fold and assembly by AlphaFold2.Biophys J2023
37609301Approximating conformational Boltzmann distributions with AlphaFold2 predictions.bioRxiv2023
37978291Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment.Nat Commun2023
37730207CFTR Folding: From Structure and Proteostasis to Cystic Fibrosis Personalized Medicine.ACS Chem Biol2023
37972196Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly.Science2023
37392556Modeling conformational states of proteins with AlphaFold.Curr Opin Struct Biol2023
37253358General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants.Cell Chem Biol2023
37119820Computational modeling and prediction of deletion mutants.Structure2023
37214798Dark nanodiscs as a model membrane for evaluating membrane protein thermostability by differential scanning fluorimetry.bioRxiv2023
37016190Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction.J Biomol NMR2023
37175495Improving the Modeling of Extracellular Ligand Binding Pockets in RosettaGPCR for Conformational Selection.Int J Mol Sci2023
37404061Acquired Secondary HER2 Mutations Enhance HER2/MAPK Signaling and Promote Resistance to HER2 Kinase Inhibition in Breast Cancer.Cancer Res2023
37339079Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y<sub>4</sub> Receptor Positive Allosteric Modulator VU0506013.J Med Chem2023
37467526Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein complex.Curr Opin Struct Biol2023
36972273Docking cholesterol to integral membrane proteins with Rosetta.PLoS Comput Biol2023
37131837Integrating Expert Knowledge with Deep Learning Improves QSAR Models for CADD Modeling.bioRxiv2023
36626571Rosetta's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery.Biochemistry2023
36876042Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties.Front Mol Biosci2023
36870682Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in the assembly of oligomeric complexes.J Biol Chem2023
36669974Targeting in silico GPCR conformations with ultra-large library screening for hit discovery.Trends Pharmacol Sci2023
36525975Benchmarking AlphaFold2 on peptide structure prediction.Structure2023
34822209Binding of Natural Peptide Ligands to the Neuropeptide Y<sub>5</sub> Receptor.Angew Chem Int Ed Engl2022
35843285Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences.J Mol Biol2022
35510622Heterogeneity of the GFP fitness landscape and data-driven protein design.Elife2022
35442947Predicting the functional impact of KCNQ1 variants with artificial neural networks.PLoS Comput Biol2022
35676279Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.Nat Commun2022
35584193Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.PLoS Pathog2022
35544577Molecular architecture of the human caveolin-1 complex.Sci Adv2022
35544469The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta.MAbs2022
35639743PlaceWaters: Real-time, explicit interface water sampling during Rosetta ligand docking.PLoS One2022
35720345Computational Structure Prediction for Antibody-Antigen Complexes From Hydrogen-Deuterium Exchange Mass Spectrometry: Challenges and Outlook.Front Immunol2022
35597243Modeling of protein conformational changes with Rosetta guided by limited experimental data.Structure2022
35715957Towards generalizable predictions for G protein-coupled receptor variant expression.Biophys J2022
35687855An Active Learning Framework Improves Tumor Variant Interpretation.Cancer Res2022
35850308Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal.J Biol Chem2022
36477260Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.PLoS Comput Biol2022
36512534Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids.PLoS One2022
35973423Integrative model of the FSH receptor reveals the structural role of the flexible hinge region.Structure2022
35969794Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter.Proc Natl Acad Sci U S A2022
35867821Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer.Proc Natl Acad Sci U S A2022
35982797Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine.iScience2022
35290761Small integral membrane protein 10 like 1 downregulation enhances differentiation of adipose progenitor cells.Biochem Biophys Res Commun2022
35073610Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors.ChemMedChem2022
35315300Confirmation of association of <i>TGFBI</i> p.Ser591Phe mutation with variant lattice corneal dystrophy.Ophthalmic Genet2022
34915025Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region.J Biol Chem2022
35216338Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na<sub>V</sub>1.5.Int J Mol Sci2022
35309920The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.Front Cell Dev Biol2022
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Collaborators

James E Crowe
Vanderbilt University Medical Center
Co-authored papers 29
Rocco Moretti
Co-authored papers 15
Alfred L George
Northwestern University Feinberg School of Medicine
Co-authored papers 14
David Baker
University of Washington
Co-authored papers 13
John A Capra
Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 12
Carlos G Vanoye
Feinberg School of Medicine, Northwestern University
Co-authored papers 12
Heidi E Hamm
Co-authored papers 8
Vincent A Miller
Injury Prevention Research Center, University of North Carolina
Co-authored papers 7
Andrea Sinz
Center for Structural Mass Spectrometry, Martin Luther University Halle-Wittenberg
Co-authored papers 5
Cinque Soto
Co-authored papers 5
Stefan Kalkhof
Institute for Bioanalysis, Coburg University of Applied Sciences and Arts
Co-authored papers 5
Rebecca Nagy
Guardant Health Inc.
Co-authored papers 4
Tanja Kortemme
University of California san francisco
Co-authored papers 4
Jeffrey J Gray
Johns Hopkins University
Co-authored papers 4
Keenan C Taylor
Vanderbilt University
Co-authored papers 4
Frank DiMaio
University of Washington
Co-authored papers 4
John A Phillips
Vanderbilt University Medical Center
Co-authored papers 4
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 4
Siraj M Ali
Foundation Medicine
Co-authored papers 4
Ora Schueler-Furman
Co-authored papers 3
Rhiju Das
Stanford University School of Medicine
Co-authored papers 3
Melanie D Ohi
Co-authored papers 3
Julie R Field
Vanderbilt Institute for Clinical and Translational Research
Co-authored papers 3
Rizwan Hamid
Vanderbilt University Medical Center
Co-authored papers 3
Richard Bonneau
Center for Computational Biology (CCB), Flatiron Institute, Simons Foundation
Co-authored papers 3
Anita M Preininger
IBM Corporation
Co-authored papers 3
Dan M Roden
Vanderbilt University Medical Center
Co-authored papers 3
Robert H Carnahan
Vanderbilt University Medical Center
Co-authored papers 3
Pedro L Teixeira
Vanderbilt University Medical Center
Co-authored papers 3
Brian Kuhlman
Co-authored papers 3
Release 1.2