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Author Details
Full Name
Lloyd J Old
Affiliation
Ludwig Institute for Cancer Research
ORCID
Career Start Year
1959
Papers
754
H Index
152
Expertise
CM4AI Collaborator
PMID
Paper Title
Journal Title
Published Year
35664317
Systems-Level Mapping of Cancer Testis Antigen 1b/a to Sarcoma Pathways Identifies Activated Ran Binding-2 E3 SUMO-Protein Ligase and Transducin-Like Enhancer Protein 1.
Front Genet
2022
32317292
Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma.
J Immunother Cancer
2020
30038035
Pillars Article: IFNγ and Lymphocytes Prevent Primary Tumour Development and Shape Tumour Immunogenicity. <i>Nature</i>. 2001. 410: 1107-1111.
J Immunol
2018
25081390
NY-ESO-1 specific antibody and cellular responses in melanoma patients primed with NY-ESO-1 protein in ISCOMATRIX and boosted with recombinant NY-ESO-1 fowlpox virus.
Int J Cancer
2015
26447332
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Sci Rep
2015
26194713
PET-based compartmental modeling of (124)I-A33 antibody: quantitative characterization of patient-specific tumor targeting in colorectal cancer.
Eur J Nucl Med Mol Imaging
2015
24764581
Nonclassical antigen-processing pathways are required for MHC class II-restricted direct tumor recognition by NY-ESO-1-specific CD4(+) T cells.
Cancer Immunol Res
2014
22864522
Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma.
Invest New Drugs
2013
24045055
Process development and production of cGMP grade Melan-A for cancer vaccine clinical trials.
Protein Expr Purif
2013
24081977
Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein.
Clin Cancer Res
2013
24195083
The human cell surfaceome of breast tumors.
Biomed Res Int
2013
23882157
NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma.
Cancer Immun
2013
23936189
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer.
PLoS One
2013
23390374
A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy.
Cancer Immun
2013
23436617
Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.
Eur J Immunol
2013
23554566
A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma.
Sarcoma
2013
23348793
Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma.
Mol Imaging
2013
21413013
Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination.
Int J Cancer
2012
23390371
MAGE-A3 is highly expressed in a subset of colorectal cancer patients.
Cancer Immun
2012
23390370
SurfaceomeDB: a cancer-orientated database for genes encoding cell surface proteins.
Cancer Immun
2012
23032745
Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients.
Clin Cancer Res
2012
22684412
A novel cancer/testis antigen KP-OVA-52 identified by SEREX in human ovarian cancer is regulated by DNA methylation.
Int J Oncol
2012
22847809
Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity.
Clin Cancer Res
2012
22840835
T cell assays and MIATA: the essential minimum for maximum impact.
Immunity
2012
22923163
KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon cancer.
Int J Oncol
2012
22437872
Antibody therapy of cancer.
Nat Rev Cancer
2012
22454499
Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients.
Proc Natl Acad Sci U S A
2012
22318866
Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.
Cancer Res
2012
22318521
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
Nature
2012
22228793
Novel mechanistic insights into arginine deiminase pharmacology suggest 18F-FDG is not suitable to evaluate clinical response in melanoma.
J Nucl Med
2012
22323448
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.
Blood
2012
22427632
Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells.
J Immunol
2012
22109656
Spontaneous antibody, and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients.
Int J Cancer
2012
22134507
Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase.
Br J Cancer
2012
21547902
Colon cancer associated transcript-1: a novel RNA expressed in malignant and pre-malignant human tissues.
Int J Cancer
2012
20346054
Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250.
BJU Int
2011
22016418
Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma.
Hum Reprod
2011
22068895
124I-huA33 antibody uptake is driven by A33 antigen concentration in tissues from colorectal cancer patients imaged by immuno-PET.
J Nucl Med
2011
22114198
Trypanosoma cruzi as an effective cancer antigen delivery vector.
Proc Natl Acad Sci U S A
2011
22168571
Defining the critical hurdles in cancer immunotherapy.
J Transl Med
2011
21858191
Split T cell tolerance against a self/tumor antigen: spontaneous CD4+ but not CD8+ T cell responses against p53 in cancer patients and healthy donors.
PLoS One
2011
21764796
(124)I-huA33 antibody PET of colorectal cancer.
J Nucl Med
2011
21933959
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.
Proc Natl Acad Sci U S A
2011
21565982
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.
Clin Cancer Res
2011
21754986
MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer.
PLoS One
2011
21698545
Immunoediting and persistence of antigen-specific immunity in patients who have previously been vaccinated with NY-ESO-1 protein formulated in ISCOMATRIXâ¿¢.
Cancer Immunol Immunother
2011
21318630
Expression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylation.
Biotechnol Lett
2011
21315712
Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.
Eur J Pharmacol
2011
21365782
Expression and purification of cGMP grade NY-ESO-1 for clinical trials.
Biotechnol Prog
2011
21305280
A proteomic analysis of the Pichia pastoris secretome in methanol-induced cultures.
Appl Microbiol Biotechnol
2011
1 - 50 of 754
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