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Author Details

William G Rice
University of Southampton Highfield Southampton SO17 1BJ UK.
1986
79
41
PMIDPaper TitleJournal TitlePublished Year
36226489Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy.Haematologica2023
36888611Luxeptinib interferes with LYN-mediated activation of SYK and modulates BCR signaling in lymphoma.PLoS One2023
36865133The multi-kinase inhibitor CG-806 exerts anti-cancer activity against acute myeloid leukemia by co-targeting FLT3, BTK, and Aurora kinases.Res Sq2023
36563938A protracted outbreak of difficult-to-treat resistant Pseudomonas aeruginosa in a haematology unit: a matched case-control study demonstrating increased risk with use of fluoroquinolone.J Hosp Infect2023
34843717Luxeptinib disables NLRP3 inflammasome-mediated IL-1β release and pathways required for secretion of inflammatory cytokines IL-6 and TNFα.Biochem Pharmacol2022
35499387Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia.Mol Cancer Ther2022
34381596Conformational fingerprinting of tau variants and strains by Raman spectroscopy.RSC Adv2021
29626126APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.Mol Cancer Ther2018
29626127APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.Mol Cancer Ther2018
22169261Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs.Bioorg Med Chem Lett2012
24900516Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.ACS Med Chem Lett2012
22789538Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.Cancer Cell2012
22460033Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells.Bioorg Med Chem Lett2012
22267551CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy.Mol Cancer Ther2012
22387988Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells.Cancer Lett2012
21159662Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.Cancer Res2011
24900437Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor.ACS Med Chem Lett2011
22027148Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer.Biochem Biophys Res Commun2011
21755459Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer.Mol Cell Biochem2011
21316963Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties.Bioorg Med Chem Lett2011
21174434Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.J Med Chem2011
20055700The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.Annu Rev Pharmacol Toxicol2010
21159648CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy.Cancer Res2010
19738048Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.Cancer Res2009
12818684Synthesis, resolution, and determination of the absolute configuration of the enantiomers of cis-4,5-dihydroxy-1,2-dithiane 1,1-dioxide, an HIV-1NCp7 inhibitor.Bioorg Med Chem2003
12639244In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model.AIDS Res Hum Retroviruses2003
11858998Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors.Bioorg Med Chem Lett2002
11886789Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents.Bioorg Med Chem2002
11325274The secondary amine/nitric oxide complex ion R(2)N[N(O)NO](-) as nucleophile and leaving group in S9N)Ar reactions.J Org Chem2001
10809733Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action.J Biol Chem2000
10574965Inhibition of G-protein-coupled receptor function by disruption of transmembrane domain interactions.J Biol Chem1999
10413422Potential drugs against cervical cancer: zinc-ejecting inhibitors of the human papillomavirus type 16 E6 oncoprotein.J Natl Cancer Inst1999
10346929Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.J Med Chem1999
10212126Chicoric acid analogues as HIV-1 integrase inhibitors.J Med Chem1999
10464020Thiazolothiazepine inhibitors of HIV-1 integrase.J Med Chem1999
9888834Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.J Med Chem1999
9751708Reactivity of the HIV-1 nucleocapsid protein p7 zinc finger domains from the perspective of density-functional theory.Proc Natl Acad Sci U S A1998
9871653Synthesis of a non-nucleoside reverse transcriptase inhibitor in the alkenyldiarylmethane (ADAM) series with optimized potency and therapeutic index.Bioorg Med Chem Lett1998
9871550Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.Bioorg Med Chem Lett1998
9665268Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function.J Leukoc Biol1998
9517921Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription.Antimicrob Agents Chemother1998
9554870Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.J Med Chem1998
9632350Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemotherapeutic and microbicidal application.J Med Chem1998
9624499Efficacies of zinc-finger-active drugs against Giardia lamblia.Antimicrob Agents Chemother1998
9622549New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.J Med Chem1998
9055865Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.Nat Med1997
9209313Suppression of retrovirial replication: inactivation of murine leukemia virus by compounds reacting with the zinc finger in the viral nucleocapsid protein.Leukemia1997
9113335A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: the 2,2'-dithiobisbenzamides.Bioorg Med Chem1997
9207937Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.J Med Chem1997
9144524Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains.J Immunol1997
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Collaborators

The Second Affiliated Hospital of Nanchang University
Co-authored papers 6
Moores Cancer Center and Department of Medicine, University of California
Co-authored papers 5
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Center for Cancer Research, National Cancer Institute
Co-authored papers 4
Oncogenesis Thematic Research Center
Co-authored papers 3
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The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Co-authored papers 2
Oregon Health & Science University
Co-authored papers 1
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Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
MD Anderson Cancer Center
Co-authored papers 1
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
Massachusetts General Hospital
Co-authored papers 1
University of Alabama at Birmingham
Co-authored papers 1
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
National Institute of Diabetes and Digestive and Kidney Diseases
Co-authored papers 1
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Co-authored papers 1
Toronto General Hospital, University Health Network, University of Toronto
Co-authored papers 1
University of Melbourne
Co-authored papers 1
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The University of Melbourne
Co-authored papers 1
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
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University of Maryland, College Park
Co-authored papers 1
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 1