Author details

Full Name

John M Louis

Affiliation

National Institute of Diabetes and Digestive and Kidney Diseases

ORCID

Career Start Year

1988

Papers

196

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36893281	Structures of brain-derived 42-residue amyloid-Î² fibril polymorphs with unusual molecular conformations and intermolecular interactions.	Proc Natl Acad Sci U S A	2023
37957287	Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors.	Commun Biol	2023
37271339	Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors.	J Biol Chem	2023
35233052	Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor.	Commun Biol	2022
35477935	Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease.	Nat Commun	2022
35700771	Real-time Exchange of the Lipid-bound Intermediate and Post-fusion States of the HIV-1 gp41 Ectodomain.	J Mol Biol	2022
36334779	Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor.	J Mol Biol	2022
36114420	Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain.	Commun Biol	2022
35877206	Global Dynamics of a Protein on the Surface of Anisotropic Lipid Nanoparticles Derived from Relaxation-Based NMR Spectroscopy.	J Phys Chem B	2022
35278268	Visualizing Proteins in Mammalian Cells by <sup>19</sup> F NMR Spectroscopy.	Angew Chem Int Ed Engl	2022
35169792	Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease: room-temperature X-ray and neutron crystallography, binding thermodynamics, and antiviral activity.	Res Sq	2022
32916024	Concentration-Dependent Structural Transition of the HIV-1 gp41 MPER Peptide into Î±-Helical Trimers.	Angew Chem Int Ed Engl	2021
33644875	A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.	EMBO J	2021
33932439	MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.	Biophys J	2021
34705466	Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease.	J Med Chem	2021
34375097	Constraints on the Structure of Fibrils Formed by a Racemic Mixture of Amyloid-Î² Peptides from Solid-State NMR, Electron Microscopy, and Theory.	J Am Chem Soc	2021
34804549	Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography.	IUCrJ	2021
34623907	Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion.	Sci Adv	2021
32558168	Probing the Interaction between HIV-1 Protease and the Homodimeric p66/p66' Reverse Transcriptase Precursor by Double Electron-Electron Resonance EPR Spectroscopy.	Chembiochem	2020
32093836	Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease.	Methods Enzymol	2020
32620782	Fast three-color single-molecule FRET using statistical inference.	Nat Commun	2020
32341150	Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles.	Proc Natl Acad Sci U S A	2020
32478251	Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design.	ACS Omega	2020
32527859	Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.	Proc Natl Acad Sci U S A	2020
31042030	Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.	J Am Chem Soc	2019
31587829	Diverse Folding Pathways of HIV-1 Protease Monomer on a Rugged Energy Landscape.	Biophys J	2019
29277995	Tilted, Uninterrupted, Monomeric HIV-1 gp41 Transmembrane Helix from Residual Dipolar Couplings.	J Am Chem Soc	2018
30230835	Three-Color Single-Molecule FRET and Fluorescence Lifetime Analysis of Fast Protein Folding.	J Phys Chem B	2018
30509980	Probing the mechanism of inhibition of amyloid-Î²(1-42)-induced neurotoxicity by the chaperonin GroEL.	Proc Natl Acad Sci U S A	2018
29512300	Co-Evolutionary Fitness Landscapes for Sequence Design.	Angew Chem Int Ed Engl	2018
28760960	Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET.	Proc Natl Acad Sci U S A	2017
28195728	Room Temperature Neutron Crystallography of Drug Resistant HIV-1 Protease Uncovers Limitations of X-ray Structural Analysis at 100 K.	J Med Chem	2017
29087351	Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR.	Proc Natl Acad Sci U S A	2017
26812046	Analysis of Fluorescence Lifetime and Energy Transfer Efficiency in Single-Molecule Photon Trajectories of Fast-Folding Proteins.	J Phys Chem B	2016
27791180	Transient HIV-1 Gag-protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations.	Proc Natl Acad Sci U S A	2016
27992544	Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.	PLoS One	2016
27170547	Evolution under Drug Pressure Remodels the Folding Free-Energy Landscape of Mature HIV-1 Protease.	J Mol Biol	2016
27513582	Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles.	PLoS One	2016
27039930	Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.	Biochemistry	2016
26958828	Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.	Angew Chem Int Ed Engl	2016
25470009	Conformation of inhibitor-free HIV-1 protease derived from NMR spectroscopy in a weakly oriented solution.	Chembiochem	2015
26385843	Pressure-induced structural transition of mature HIV-1 protease from a combined NMR/MD simulation approach.	Proteins	2015
26506247	The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region.	Biochemistry	2015
26266692	Mutations Proximal to Sites of Autoproteolysis and the Î±-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease.	Biochemistry	2015
26336107	Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40.	J Biol Chem	2015
26182121	Testing Landscape Theory for Biomolecular Processes with Single Molecule Fluorescence Spectroscopy.	Phys Rev Lett	2015
26010498	Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20.	J Med Chem	2015
25631354	Complete dissociation of the HIV-1 gp41 ectodomain and membrane proximal regions upon phospholipid binding.	J Biomol NMR	2015
25757985	Dependence of distance distributions derived from double electron-electron resonance pulsed EPR spectroscopy on pulse-sequence time.	Angew Chem Int Ed Engl	2015
24550514	Dissociation of the trimeric gp41 ectodomain at the lipid-water interface suggests an active role in HIV-1 Env-mediated membrane fusion.	Proc Natl Acad Sci U S A	2014

1 - 50 of 196

Jonathan E Gable

Novartis Institute for Tropical Diseases

Career Start Year 2008

Number of shared co-authors 1

Rick K Huang

National Cancer Institute, National Institutes of Health

Career Start Year 2007

Number of shared co-authors 2

James B Munro

University of Massachusetts Chan Medical School

Career Start Year 2004

Number of shared co-authors 0

Tsutomu Matsui

Stanford University

Career Start Year 2003

Number of shared co-authors 1

Kelly K Lee

University of Washington

Career Start Year 2002

Number of shared co-authors 2

Lewyn Li

Dana-Farber Cancer Institute, Harvard Medical School

Career Start Year 2000

Number of shared co-authors 0

Udupi A Ramagopal

Poornaprajna Institute of Scientific Research (PPISR)

Career Start Year 1998

Number of shared co-authors 2

Nikolay V Dokholyan

Pennsylvania State University College of Medicine

Career Start Year 1998

Number of shared co-authors 2

Li-Chung Ma

Robert Wood Johnson Medical School, The State University of New Jersey

Career Start Year 1997

Number of shared co-authors 2

Michele Vendruscolo

University of Cambridge

Career Start Year 1996

Number of shared co-authors 4

Witek Kwiatkowski

Swiss Federal Institute of Technology

Career Start Year 1996

Number of shared co-authors 1

Shira Albeck

Weizmann Institute of Science

Career Start Year 1996

Number of shared co-authors 2

Zihe Rao

Nankai University

Career Start Year 1995

Number of shared co-authors 2

James C Whisstock

Monash University

Career Start Year 1994

Number of shared co-authors 1

Alexander P Golovanov

The University of Manchester

Career Start Year 1991

Number of shared co-authors 4

Celia A Schiffer

University of Massachusetts Chan Medical School

Career Start Year 1990

Number of shared co-authors 1

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 3

Piotr Cieplak

Sanford-Burnham-Prebys Medical Discovery Institute

Career Start Year 1987

Number of shared co-authors 0

Raymond J Owens

University of Oxford

Career Start Year 1986

Number of shared co-authors 2

Raghavan Varadarajan

Indian Institute of Science

Career Start Year 1985

Number of shared co-authors 1

Lu-Yun Lian

Institute of Systems, The University of Liverpool

Career Start Year 1984

Number of shared co-authors 4

Wesley I Sundquist

University of Utah School of Medicine

Career Start Year 1982

Number of shared co-authors 1

William F DeGrado

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1982

Number of shared co-authors 1

Charles S Craik

Department of Pharmaceutical Chemistry, University of California san francisco

Career Start Year 1980

Number of shared co-authors 1

David I Stuart

University of Oxford

Career Start Year 1976

Number of shared co-authors 3

Ian A Wilson

The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology

Career Start Year 1975

Number of shared co-authors 2

James A Wells

Department of Pharmaceutical Chemistry, University of California San Francisco

Career Start Year 1974

Number of shared co-authors 1

Charles L Brooks

University of Michigan ann arbor

Career Start Year 1974

Number of shared co-authors 2

Wayne A Hendrickson

Columbia University

Career Start Year 1968

Number of shared co-authors 2

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 2

row(s) 1 - 30 of 30

Angela M Gronenborn

University of Pittsburgh

Co-authored papers 26

Ad Bax

National Institutes of Health

Co-authored papers 22

Rieko Ishima

University of Pittsburgh School of Medicine

Co-authored papers 18

Laura G Barrientos

CNRS, Universite de Strasbourg

Co-authored papers 5

Chen-Hsiang Shen

Co-authored papers 4

Ram??n Campos-Olivas

Spanish National Cancer Research Centre (CNIO)

Co-authored papers 3

Troy Wymore

Co-authored papers 2

Andras Fiser

Albert Einstein College of Medicine

Co-authored papers 1

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 1

Peter N Devreotes

Co-authored papers 1

Timothy R Fouts

Profectus BioSciences Inc.

Co-authored papers 1

Alasdair C Steven

National Institutes of Health

Co-authored papers 1

William G Rice

University of Southampton Highfield Southampton SO17 1BJ UK.

Co-authored papers 1

Douglas D Richman

Center for AIDS Research, University of California San Diego

Co-authored papers 1

James J Chou

Harvard Medical School

Co-authored papers 1

Charles D Schwieters

National Institute of Diabetes and Digestive and Kidney Diseases

Co-authored papers 1

Lance A Liotta

Co-authored papers 1

Tom Curran

Medical University of South Carolina

Co-authored papers 1

David C Montefiori

Co-authored papers 1

Lisa M Miller Jenkins

National Cancer Institute, National Institutes of Health

Co-authored papers 1

Dimiter S Dimitrov

Co-authored papers 1

Xiuqian Mu

University at Buffalo, State University of New York

Co-authored papers 1

1 - 22

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