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Author Details

Jirong Lu
Lilly Research Laboratories
1992
28
20
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
32370596<i>Post-hoc</i> assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms.MAbs2020
32486889Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies.MAbs2020
31181988Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.MAbs2019
29134678Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models.Glia2018
28406969Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages.PLoS One2017
26849155Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure.Mol Pharm2016
27143947Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A.J Inflamm Res2016
25771799Increased brain bio-distribution and chemical stability and decreased immunogenicity of an engineered variant of GDNF.Exp Neurol2015
26337808The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.MAbs2015
25695748Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.MAbs2015
25039923Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET).Histopathology2014
25231402LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth.Clin Cancer Res2014
23383873Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates.Mol Pharm2013
23396084Qualification of a free ligand assay in the presence of anti-ligand antibody Fab fragments.MAbs2013
22377715Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.MAbs2012
23217740A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice.Neuron2012
22584253FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.Drug Metab Dispos2012
21412957Discovery of potent, cyclic calcitonin gene-related peptide receptor antagonists.J Pept Sci2011
15732928In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.Anal Chem2005
16101294IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.Biochemistry2005
11907226Oligomerization and cooperative RNA synthesis activity of hepatitis C virus RNA-dependent RNA polymerase.J Virol2002
10545167Methionine and alanine substitutions show that the formation of wild-type-like structure in the carboxy-terminal domain of T4 lysozyme is a rate-limiting step in folding.Biochemistry1999
9265619Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy.Biochemistry1997
9127942Thermal unfolding of the N-terminal RNA binding domain of the human U1A protein studied by differential scanning calorimetry.Biophys Chem1997
8844847Contribution of the tyrosines to the structure and function of the human U1A N-terminal RNA binding domain.Protein Sci1996
7723028An RBD that does not bind RNA: NMR secondary structure determination and biochemical properties of the C-terminal RNA binding domain from the human U1A protein.J Mol Biol1995
1510962Protein folding: assignment of the energetic changes of reversible chemical modifications to the folded or unfolded states.Biochemistry1992
1591236Detection and characterization of an early folding intermediate of T4 lysozyme using pulsed hydrogen exchange and two-dimensional NMR.Biochemistry1992
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Collaborators

Ling Liu
Lilly Research Laboratories
Co-authored papers 5
Wei Zeng
Lilly Research Laboratories
Co-authored papers 4
Shane Atwell
Lilly Research Laboratories
Co-authored papers 2
Christine Humblet
Lilly Research Laboratories
Co-authored papers 1
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Qi Chen
Lilly Research Laboratories
Co-authored papers 1
Joseph M Colacino
Co-authored papers 1
Robert J Benschop
Co-authored papers 1
Michael Vieth
Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg
Co-authored papers 1
David E Timm
Lilly Research Laboratories
Co-authored papers 1
Nadine C Gassner
UC Santa Cruz Genomics Institute, University of California
Co-authored papers 1
Ilan E Chemmama
University of California san francisco
Co-authored papers 1
Dina Schneidman-Duhovny
The Hebrew University of Jerusalem
Co-authored papers 1
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