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Author Details

Paul A Clemons
Broad Institute
1999
116
48
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37919549DNA-encoded library-enabled discovery of proximity-inducing small molecules.Nat Chem Biol2024
37919549DNA-encoded library-enabled discovery of proximity-inducing small molecules.Nat Chem Biol2024
36914634Reference compounds for characterizing cellular injury in high-content cellular morphology assays.Nat Commun2023
37582753Diversity-oriented synthesis encoded by deoxyoligonucleotides.Nat Commun2023
37989745Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.Nat Commun2023
37024492Mapping the landscape of genetic dependencies in chordoma.Nat Commun2023
37485377Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells.iScience2023
36914634Reference compounds for characterizing cellular injury in high-content cellular morphology assays.Nat Commun2023
37485377Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells.iScience2023
37582753Diversity-oriented synthesis encoded by deoxyoligonucleotides.Nat Commun2023
37989745Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.Nat Commun2023
37024492Mapping the landscape of genetic dependencies in chordoma.Nat Commun2023
36125173Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science.Clin Transl Sci2022
35439415Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.ACS Chem Biol2022
36125173Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science.Clin Transl Sci2022
35535861Machine Learning on DNA-Encoded Library Count Data Using an Uncertainty-Aware Probabilistic Loss Function.J Chem Inf Model2022
36396978A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.Nat Cell Biol2022
35439415Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.ACS Chem Biol2022
35535861Machine Learning on DNA-Encoded Library Count Data Using an Uncertainty-Aware Probabilistic Loss Function.J Chem Inf Model2022
36396978A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.Nat Cell Biol2022
34130532The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.SLAS Discov2021
34130532The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.SLAS Discov2021
33521702Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.Cell Rep Med2021
33521702Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.Cell Rep Med2021
32231343Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.Nat Chem Biol2020
32231343Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles.Nat Chem Biol2020
32939090Plasticity of ether lipids promotes ferroptosis susceptibility and evasion.Nature2020
32939090Plasticity of ether lipids promotes ferroptosis susceptibility and evasion.Nature2020
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
30548204Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries.ChemMedChem2019
30519951Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.Methods Mol Biol2019
31184885DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.J Am Chem Soc2019
31028261High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.Nat Commun2019
30860482Renal medullary carcinomas depend upon <i>SMARCB1</i> loss and are sensitive to proteasome inhibition.Elife2019
30962421A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.Nat Commun2019
31266947Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.Nat Commun2019
31051099A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.Cell2019
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
30880155Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.Cell Chem Biol2019
31184885DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.J Am Chem Soc2019
31266947Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.Nat Commun2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
30860482Renal medullary carcinomas depend upon <i>SMARCB1</i> loss and are sensitive to proteasome inhibition.Elife2019
31028261High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.Nat Commun2019
30880155Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.Cell Chem Biol2019
31051099A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.Cell2019
30962421A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.Nat Commun2019
30548204Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries.ChemMedChem2019
30519951Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.Methods Mol Biol2019
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Collaborators

Stuart L Schreiber
Broad Institute
Co-authored papers 68
Bridget K Wagner
Co-authored papers 32
Vlado Dan????k
Broad Institute
Co-authored papers 31
Alykhan F Shamji
Center for the Science of Therapeutics, Broad Institute
Co-authored papers 27
Joshua A Bittker
Co-authored papers 18
Jaime H Cheah
Johns Hopkins University School of Medicine
Co-authored papers 9
Timothy A Lewis
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 8
David E Root
Broad Institute of Harvard and MIT
Co-authored papers 8
Anne E Carpenter
Broad Institute of MIT and Harvard
Co-authored papers 8
Matthew G Rees
Co-authored papers 8
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 8
William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 8
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 7
Stephen J Haggarty
Co-authored papers 7
James E Bradner
Co-authored papers 6
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 5
Francisca Vazquez
Broad Institute of MIT and Harvard
Co-authored papers 5
Amit Choudhary
Broad Institute of MIT and Harvard
Co-authored papers 5
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 5
Aravind Subramanian
Co-authored papers 5
Pablo Tamayo
University of California San Diego
Co-authored papers 4
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 4
Brent R Stockwell
Columbia University
Co-authored papers 4
John G Doench
Co-authored papers 4
Benjamin Alexander
Co-authored papers 4
Barbara A Weir
Janssen Research and Development LLC
Co-authored papers 4
Stefan Kubicek
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 4
Shantanu Singh
Co-authored papers 4
David L Lahr
Co-authored papers 4
Jill P Mesirov
University of California San Diego
Co-authored papers 3
Release 1.2