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Author Details

J. Wade Harper
Harvard Medical School
1981
321
120
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36824886Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models.bioRxiv2023
37490852ER membrane curvature and ubiquitin as drivers of ER-phagy.Dev Cell2023
37757899Proteome census upon nutrient stress reveals Golgiphagy membrane receptors.Nature2023
37953912UniProtExtractR: an app and R package for easily extracting protein-specific UniProtKB information and fine-tuning organelle resolution.Bioinform Adv2023
37334901PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems.EMBO Rep2023
36469690Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.Autophagy2023
35051374Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.Neuron2022
35760976The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.Nat Commun2022
35364016Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy.Mol Cell2022
36713230Mechanisms Controlling Selective Elimination of Damaged Lysosomes.Curr Opin Physiol2022
36245040Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics.Nat Commun2022
36207292Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.Nat Commun2022
34942047Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes.EMBO J2022
35000205Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.Ann N Y Acad Sci2022
34012123Host ubiquitin protein tags lipid to fight bacteria.Nature2021
33827988ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.Proc Natl Acad Sci U S A2021
33823649Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis.Annu Rev Biochem2021
33536245Quantitative intravital imaging in zebrafish reveals <i>in vivo</i> dynamics of physiological-stress-induced mitophagy.J Cell Sci2021
33689365Super Heavy TMTpro Labeling Reagent: An Alternative and Higher-Charge-State-Amenable Stable-Isotope-Labeled TMTpro Variant.J Proteome Res2021
34469731iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.Cell Rep2021
34819669A multi-scale map of cell structure fusing protein images and interactions.Nature2021
34585663Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy.Elife2021
34699746Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.Mol Cell2021
34767452Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.Sci Adv2021
33961781Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.Cell2021
32393902Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming.Nat Struct Mol Biol2020
31902706Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons.Stem Cell Reports2020
32744497EDF1 coordinates cellular responses to ribosome collisions.Elife2020
32973005The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.Science2020
32345721Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant <i>wobbler</i> mice, a model of motor neuron degeneration.Proc Natl Acad Sci U S A2020
30846318Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.Mol Cell2019
31787617The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai <i>et al</i>.).Haematologica2019
31723608Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.Sci Adv2019
31413265The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells.Sci Rep2019
31375563Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes.J Biol Chem2019
31543463Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.Cancer Cell2019
31196865Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells.Genes Dev2019
31006537TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.Mol Cell2019
29054129BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data.J Proteome Res2018
32034369Protein aggregates caught stalling.Nature2018
30257870Angelman syndrome-associated point mutations in the Zn<sup>2+</sup>-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.J Biol Chem2018
30627666RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway.Sci Adv2018
29360040Endosomal Rab cycles regulate Parkin-mediated mitophagy.Elife2018
29358684Building and decoding ubiquitin chains for mitophagy.Nat Rev Mol Cell Biol2018
29656925Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.Mol Cell2018
29565390Protein aggregates caught stalling.Nature2018
29230017Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.Nat Cell Biol2018
28581483Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.Nat Chem Biol2017
28489822TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.Nature2017
28192421G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.Nat Cell Biol2017
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Collaborators

Stephen J Elledge
Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 58
Steven P Gygi
Harvard Medical School
Co-authored papers 39
Edward L Huttlin
Harvard Medical School
Co-authored papers 13
Laura Pontano Vaites
Harvard Medical School
Co-authored papers 13
Andre J van Wijnen
Co-authored papers 6
Ivan Dikic
Institute of Biochemistry II, Goethe University Frankfurt
Co-authored papers 6
Gary S Stein
University of Vermont
Co-authored papers 6
Joseph D Mancias
Dana-Farber Cancer Institute
Co-authored papers 6
Peter D Adams
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 6
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 5
Bo Zhai
Co-authored papers 5
Malene Hansen
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 4
Jun Qin
Co-authored papers 4
Nikola P Pavletich
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Tobias C Walther
Harvard T. H. Chan School of Public Health
Co-authored papers 3
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 3
Jayanta Debnath
University of California San Francisco
Co-authored papers 3
Devin K Schweppe
Co-authored papers 3
Jiuchun Zhang
Co-authored papers 3
Gregory J Hannon
Co-authored papers 3
Richard J Youle
Co-authored papers 3
Robert V Farese
Harvard T.H. Chan School of Public Health
Co-authored papers 3
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 3
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 3
Michael Rape
Howard Hughes Medical Institute, University of California at Berkeley
Co-authored papers 3
Sebastian Boland
Co-authored papers 3
Agata Smogorzewska
Instituto de Investigacion Sanitaria Hospital 12 de Octubre (imas12)
Co-authored papers 3
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 3
Robert A Obar
Harvard Medical School
Co-authored papers 2
Thomas J Begley
University at Albany
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