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Author Details

Leah E Cowen
University of Toronto
1999
148
48
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35231147Bacterial-fungal interactions and their impact on microbial pathogenesis.Mol Ecol2023
38015416DYRK-family kinases regulate <i>Candida albicans</i> morphogenesis and virulence through the Ras1/PKA pathway.mBio2023
37500616Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.Nat Commun2023
37607350Potent Antifungal Activity of Penta-<i>O</i>-galloyl-β-d-Glucose against Drug-Resistant <i>Candida albicans</i>, <i>Candida auris</i>, and Other Non-<i>albicans Candida</i> Species.ACS Infect Dis2023
38038475Respiration supports intraphagosomal filamentation and escape of <i>Candida albicans</i> from macrophages.mBio2023
37024700Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida albicans.Methods Mol Biol2023
37039635Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1.mSphere2023
37273644Imidazopyridine Amides: Synthesis, <i>Mycobacterium smegmatis</i> CIII<sub>2</sub>CIV<sub>2</sub> Supercomplex Binding, and In Vitro Antimycobacterial Activity.ACS Omega2023
37369212Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.Cell Chem Biol2023
37399670Roles of Hsp90 in Candida albicans morphogenesis and virulence.Curr Opin Microbiol2023
37225985Selective control of parasitic nematodes using bioactivated nematicides.Nature2023
36879823Functional genomic analysis of <i>Candida albicans</i> protein kinases reveals modulators of morphogenesis in diverse environments.iScience2023
36809010Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.mBio2023
34525326Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.Structure2022
35584803Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens.ACS Chem Biol2022
35650665Genomic Approaches to Antifungal Drug Target Identification and Validation.Annu Rev Microbiol2022
35674949Downregulation of Essential Genes in the Fungal Pathogen Candida auris.Methods Mol Biol2022
35372097Editorial: Antifungal Pipeline: Build It Strong; Build It Better!Front Cell Infect Microbiol2022
35531664High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11.mSphere2022
35663022Functional analysis of the <i>Candida albicans</i> kinome reveals Hrr25 as a regulator of antifungal susceptibility.iScience2022
35752611Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.Nat Commun2022
35512834Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <i>Candida albicans</i>.Life Sci Alliance2022
36179219The future of fungi: threats and opportunities.G3 (Bethesda)2022
36037637Antifungal discovery.Curr Opin Microbiol2022
36300931The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis.mBio2022
36294667Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens.J Fungi (Basel)2022
36226807The GARP complex is required for filamentation in Candida albicans.Genetics2022
36323314Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.Cell Host Microbe2022
35281744The role of <i>Candida albicans</i> stress response pathways in antifungal tolerance and resistance.iScience2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34849848Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence.Genetics2022
35196462Exploring Space via Astromycology: A Report on the CIFAR Programs <i>Earth 4D</i> and <i>Fungal Kingdom</i> Inaugural Joint Meeting.Astrobiology2022
32441527Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond.Chem Rev2021
33626353Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis.Cell Rep2021
33484500Fluorescence Polarization-Based Measurement of Protein-Ligand Interaction in Fungal Cell Lysates.Curr Protoc2021
33558691Treatment strategies for cryptococcal infection: challenges, advances and future outlook.Nat Rev Microbiol2021
33585877Showcasing Fungal Genetics &amp; Genomics with the Genetics Society of America.G3 (Bethesda)2021
33724422Showcasing Fungal Genetics &amp; Genomics with the Genetics Society of America.Genetics2021
34875240Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata.Curr Biol2021
34764269Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.Nat Commun2021
34433036The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans.Cell Rep2021
34686660A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.Nat Commun2021
34506483A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling.PLoS Genet2021
34079890Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action.ACS Cent Sci2021
33964438Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides.Bioorg Med Chem Lett2021
34143207Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans.Genetics2021
33444025Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.J Med Chem2021
32860238Advances in fungal chemical genomics for the discovery of new antifungal agents.Ann N Y Acad Sci2021
32717148The Canadian Fungal Research Network: current challenges and future opportunities.Can J Microbiol2021
31513387Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors.J Med Chem2020
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University of Toronto
Co-authored papers 25
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University of Toronto
Co-authored papers 10
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Lunenfeld-Tanenbaum Research Institute
Co-authored papers 8
Alexei Savchenko
University of Toronto
Co-authored papers 5
Susan Lindquist
Whitehead Institute for Biomedical Research
Co-authored papers 4
Jason E Stajich
University of California-Riverside
Co-authored papers 3
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University of Michigan ann arbor
Co-authored papers 3
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Johns Hopkins Bloomberg School of Public Health
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Co-authored papers 2
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Whitehead Institute
Co-authored papers 2
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Co-authored papers 2
Brenda J Andrews
University of Toronto
Co-authored papers 2
Owen Ryan
University of California berkeley
Co-authored papers 2
Patricia M Kane
SUNY Upstate Medical University
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University of California
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Jennifer Yang
Chang Gung Memorial Hospital
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University of California Berkeley
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Reysha Patel
University of California
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William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
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Dax Torti
Ontario Institute for Cancer Research
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Igor Stagljar
University of Toronto, Canada Mediterranean Institute for Life Sciences
Co-authored papers 1
Tomas Babak
Queen's University
Co-authored papers 1
Christophe d'Enfert
Institut Pasteur, Universite Paris Cite
Co-authored papers 1
Sabine Ottilie
University of California San Diego
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Matthew Abraham
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Release 1.2