Skip to Main Content

Author Details

Timothy P Rolph
1981
47
29
PMIDPaper TitleJournal TitlePublished Year
37141854Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.2023
34773249Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats.British Journal of Pharmacology2022
36644237A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.JHEP Rep2022
34239138Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.Nat Med2021
33176135Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.Cell Rep2020
31959001Variations in rest-activity rhythm are associated with clinically measured disease severity in Parkinson's disease.Chronobiology International2020
31948295Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?Expert Opinion on Investigational Drugs2020
33381084FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases.Frontiers in Endocrinology2020
33205064AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients.Cell Reports Medicine2020
31092695Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.Sci Transl Med2019
29664898Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.PLoS Biol2018
28289077Selective Activation of AMPK 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.Journal of Pharmacology and Experimental Therapeutics2017
28573777Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.Diabetes, Obesity and Metabolism2017
28323820Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.PLoS Biol2017
27746128A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.Cell Chemical Biology2016
27113485Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy.Journal of the American Society of Nephrology : JASN2016
27391855Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.ACS Chemical Biology2016
26748706The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.Cell Rep2016
27059951Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus.Diabetes, Obesity and Metabolism2016
26959184A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.2016
26734723Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.Journal of Medicinal Chemistry2016
27408778Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export.Mol Metab2016
26620127Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).Scientific Reports2015
26389676Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.J Clin Invest2015
26254576Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.Diabetologia2015
26153793FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.Scientific Reports2015
24584071Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Nat Genet2014
24858947The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.PLoS ONE2014
24097065Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.Nat Genet2013
22196621Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.Journal of Medicinal Chemistry2012
9300538Duration of protective immunity against ovine haemonchosis following vaccination with the nematode gut membrane antigen H11.Research in Veterinary Science1997
8945548Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.Infection and Immunity1996
7558570Vaccination of sheep against haemonchosis with H11, a gut membrane-derived protective antigen from the adult parasite: prevention of the periparturient rise and colostral transfer of protective immunity.International Journal for Parasitology1995
7635627Protection against multiply drug-resistant and geographically distant strains of Haemonchus contortus by vaccination with H11, a gut membrane-derived protective antigen.International Journal for Parasitology1995
7831742Influence of the beta-agonist salbutamol on claw horn lesions and walking soundness in finishing pigs.Veterinary Record1994
22061653Eating quality of meat from pigs given the beta-adrenergic agonist salbutamol.Meat Science1991
2262419Interactions between the beta-adrenergic agonist salbutamol and genotype on meat quality in pigs.Journal of Animal Science1990
2303392The effects of the beta-adrenergic agonist salbutamol on meat quality in pigs.Journal of Animal Science1990
2277183Studies on the growth of the fetal guinea pig. The effects of nutritional manipulation on prenatal growth and plasma somatomedin activity and insulin-like growth factor concentrations.1990
2746724The effects of salbutamol on blood pressure and heart rate in Large White and Pietrain-cross breeds of pig.Journal of Veterinary Pharmacology and Therapeutics1989
3885272Metabolism during fetal life: a functional assessment of metabolic development.Physiological Reviews1985
6526985Studies on the growth of the fetal guinea pig. The effects of ligation of the uterine artery on organ growth and development.1984
6300215Regulation of glycolytic flux in the heart of the fetal guinea pig.1983
7202024Delayed development of gluconeogenic capacity and the appearance of hypoglycaemia in the newborn guinea-pig after intra-uterine growth restriction.1982
6211993Ultrastructural and enzymatic development of fetal guinea pig heart.American Journal of Physiology1982
7215668Glucose metabolism in the perfused heart of the foetal guinea pig.Biochemical Society Transactions1981
6802587Metabolic events associated with the preparation of the fetus for independent life.Ciba Foundation symposium1981
  • 1 - 47 of 47

Recommended Authors

Collaborators

Co-authored papers 7
Co-authored papers 6
Duke Molecular Physiology Institute
Co-authored papers 4
Duke Molecular Physiology Institute
Co-authored papers 4
Duke University School of Medicine
Co-authored papers 3
Duke University Medical Center
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Innovative Genomics Institute, University of California berkeley
Co-authored papers 2
Broad Institute of Harvard and Massachusetts Institute of Technology (MIT)
Co-authored papers 2
Rinat (Pfizer Inc.)
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Alabama College of Osteopathic Medicine
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Broad Institute of MIT and Harvard
Co-authored papers 2
Duke Molecular Physiology Institute, Duke University School of Medicine
Co-authored papers 2
Co-authored papers 2
Pinnacle Clinical Research Center
Co-authored papers 2
Co-authored papers 2
Beth Israel Deaconess Medical Center
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 1
Co-authored papers 1
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Brigham and Women's Hospital (Y.K.
Co-authored papers 1
Co-authored papers 1