Author details

Full Name

William J Astle

Affiliation

ORCID

Career Start Year

2012

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36993312	Genetic regulation of fetal hemoglobin across global populations.	medRxiv	2023
37596262	A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.	Nat Commun	2023
37647652	A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.	Blood	2023
36691583	On randomized sketching algorithms and the Tracy-Widom law.		2023
34581777	G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.	Blood Adv	2022
35125502	Statistical properties of sketching algorithms.	Biometrika	2021
33960432	Familial pseudohyperkalemia induces significantly higher levels of extracellular potassium in early storage of red cell concentrates without affecting other standard measures of quality: A case control and allele frequency study.	Transfusion	2021
33783834	Advances in understanding the pathogenesis of hereditary macrothrombocytopenia.	Br J Haematol	2021
32888493	Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.	Cell	2020
32750130	Development and validation of a universal blood donor genotyping platform: a multinational prospective study.	Blood Adv	2020
32693407	Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome.	Blood	2020
32888494	The Polygenic and Monogenic Basis of Blood Traits and Diseases.	Cell	2020
31719529	Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.	Nature Communications	2019
29187380	Nbeal2 interacts with Dock7, Sec16a, and Vac14.	Blood	2018
30390057	Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.	Nat Genet	2018
29676281	Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599â¿¿912 current drinkers in 83 prospective studies.	Lancet	2018
28134622	Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.	J Clin Invest	2017
28542600	SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.	PLoS One	2017
28703137	Platelet function is modified by common sequence variation in megakaryocyte super enhancers.	Nat Commun	2017
28064200	Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.	Blood	2017
27863252	The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.	Cell	2016
26912466	A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.	Blood	2016
27668658	Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.	Nat Genet	2016
24853927	Bayesian deconvolution and quantification of metabolites in complex 1D NMR spectra using BATMAN.		2014
25258084	Transcriptional diversity during lineage commitment of human blood progenitors.	Science	2014
24281695	Flexible analysis of RNA-seq data using mixed effects models.	Bioinformatics	2014
23552273	The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women.	BMC Cardiovasc Disord	2013
22635605	BATMAN--an R package for the automated quantification of metabolites from nuclear magnetic resonance spectra using a Bayesian model.		2012