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Author Details

Penelope A Morel
University of Pittsburgh
1982
101
41
PMIDPaper TitleJournal TitlePublished Year
36710922Recent insights into the role of Akt in CD4 T-cell activation and differentiation: alternative splicing and beyond.Immunometabolism (Cobham)2023
37546701Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment.Cancer Res Commun2023
33442689COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes.bioRxiv2021
34260666COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes.PLoS Pathog2021
34224767Proinflammatory TH17 cytokine activation, disease severity and outcomes in peripartum cardiomyopathy.Int J Cardiol2021
29079307Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study.J Card Fail2018
29722021Differential T-cell receptor signals for T helper cell programming.Immunology2018
27919524Demystifying the cytokine network: Mathematical models point the way.Cytokine2017
28600288TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs.J Immunol2017
27119628Reductionism Is Dead: Long Live Reductionism! Systems Modeling Needs Reductionist Experiments.Biophys J2016
25512378Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6).J Biol Chem2015
26485716In Vivo Quantification of Inflammation in Experimental Autoimmune Encephalomyelitis Rats Using Fluorine-19 Magnetic Resonance Imaging Reveals Immune Cell Recruitment outside the Nervous System.PLoS One2015
25855357Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions.J Immunol2015
25699058Dendritic cell control of immune responses.Front Immunol2015
24737163Low TCR signal strength induces combined expansion of Th2 and regulatory T cell populations that protect mice from the development of type 1 diabetes.Diabetologia2014
25238901An immunology primer for computational modelers.J Pharmacokinet Pharmacodyn2014
25396341The physician scientist: balancing clinical and research duties.Nat Immunol2014
25155903Modeling the T cell immune response: a fascinating challenge.J Pharmacokinet Pharmacodyn2014
23211929Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.Microbes Infect2013
24367363Dendritic cell subsets in type 1 diabetes: friend or foe?Front Immunol2013
24194584The duration of T cell stimulation is a critical determinant of cell fate and plasticity.Sci Signal2013
22851575Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver.Diabetes2012
20123131Hematopoietic cell types: prototype for a revised cell ontology.J Biomed Inform2011
21789257Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque.PLoS One2011
21628331Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules.J Leukoc Biol2011
21638273GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production.Arthritis Rheum2011
21717078Dendritic cells and the maintenance of self-tolerance.Immunol Res2011
21373184The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis.PLoS One2011
20713880T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.J Immunol2010
21822455Designing the optimal vaccine: the importance of cytokines and dendritic cells.Open Vaccine J2010
19333920Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis.Arthritis Rheum2009
19585593In vivo cytometry of antigen-specific t cells using 19F MRI.Magn Reson Med2009
19801514Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion.J Immunol2009
19368560The companions: regulatory T cells and gene therapy.Immunology2009
18050383Subclinical coronary artery calcification and relationship to disease duration in women with rheumatoid arthritis.J Rheumatol2008
17182557IFN-gamma negatively regulates CpG-induced IL-10 in bone marrow-derived dendritic cells.J Immunol2007
17899609Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model.Magn Reson Med2007
17430097Naturally occurring regulatory T cells: recent insights in health and disease.Crit Rev Immunol2007
16609350Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies.Medicine (Baltimore)2006
17337777Dendritic cell immunotherapy for autoimmune diabetes.Immunol Res2006
17337776New insights into mathematical modeling of the immune system.Immunol Res2006
17075818HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies.Arthritis Rheum2006
16785568Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells.J Immunol2006
15961574Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy.J Leukoc Biol2005
16267409Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians.Medicine (Baltimore)2005
16338343In vivo imaging of autoimmune disease in model systems.Curr Top Dev Biol2005
15832295Impaired IL-4 production by CD8+ T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter.Eur J Immunol2005
16041364In vivo imaging platform for tracking immunotherapeutic cells.Nat Biotechnol2005
14670327DNA immunisation: altering the cellular localisation of expressed protein and the immunisation route allows manipulation of the immune response.Vaccine2004
15334114Fc gamma R expression on NK cells influences disease severity in rheumatoid arthritis.Genes Immun2004
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Collaborators

Co-authored papers 4
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University of Texas McGovern Medical School
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Children's Hospital Oakland Research Institute
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National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
University of Pittsburgh
Co-authored papers 1
Carnegie Mellon University
Co-authored papers 1
Center for Vaccines and Immunology, University of Georgia
Co-authored papers 1
Mission Hospital
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
The Ohio State University Comprehensive Cancer Center
Co-authored papers 1
Seattle Children's Research Institute
Co-authored papers 1
Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
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National Institute of Allergy and Infectious Diseases/National Institutes of Health
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University of Washington School of Medicine
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Lane Center for Computational Biology, Carnegie Mellon University
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University of California san francisco
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University of Rochester Medical Center
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University of Minnesota
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Duke University School of Medicine
Co-authored papers 1
McGill University
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Carnegie Mellon University
Co-authored papers 1