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Author Details

T K Harden
1973
297
87
PMIDPaper TitleJournal TitlePublished Year
36958516Loss of P2Y receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro.2023
31889510Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations.eLife2019
29263090A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes.Journal of Biological Chemistry2018
27742837Potent and Selective Peptide-based Inhibition of the G Protein Gαq.J Biol Chem2016
27421735UDP-glucose promotes neutrophil recruitment in the lung.Purinergic Signal2016
27331270Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.J Med Chem2016
26303895Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y⿁⿿ receptor.Bioorg Med Chem Lett2015
25829059UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.Molecular Pharmacology2015
25943115The First 50 Years of Molecular Pharmacology.Molecular Pharmacology2015
26658454The experimental power of FR900359 to study Gq-regulated biological processes.Nat Commun2015
25193662Membrane-induced allosteric control of phospholipase C-β isozymes.Journal of Biological Chemistry2014
25299434Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes.ACS Chem Biol2014
25036778A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.2014
24714193Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.Molecules2014
247128324-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.J Med Chem2014
23297405Small molecule inhibitors of phospholipase C from a novel high-throughput screen.Journal of Biological Chemistry2013
23777354Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes.Biochemistry2013
23908386Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17.Journal of Pharmacology and Experimental Therapeutics2013
24150253Enigmatic GPCR finds a stimulating drug.Science Signaling2013
23592514A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.Mol Pharmacol2013
23211529G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.Sci Signal2012
22703043Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.Biochemistry2012
22386981Synthesis and P2Yâ¿¿ receptor agonist activities of uridine 5'-phosphonate analogues.Bioorg Med Chem2012
22831801Virtual screening leads to the discovery of novel non-nucleotide P2Y⿁ receptor antagonists.Bioorg Med Chem2012
22673622The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.American Journal of Physiology - Cell Physiology2012
22403074The phospholipase C isozymes and their regulation.Sub-Cellular Biochemistry2012
21988240Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.Chemical Reviews2011
21108629Ser352 and Ser354 in the carboxyl terminus of the human P2Y(1) receptor are required for agonist-promoted phosphorylation and internalization in MDCK cells.British Journal of Pharmacology2011
21528910Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.J Med Chem2011
21586365Molecular pharmacology, physiology, and structure of the P2Y receptors.Advances in Pharmacology2011
21712381Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis.Journal of Biological Chemistry2011
22172670A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.Developmental Cell2011
20446735Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.J Med Chem2010
20807769Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Journal of Biological Chemistry2010
20966218Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.Science2010
19902968Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.J Med Chem2010
20565071Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.Bioconjug Chem2010
20345417Signalling and pharmacological properties of the P2Y receptor.Acta Physiologica2010
20121074Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.Bioconjug Chem2010
20594939Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500).Pharmacol Res2010
20592187Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal.Journal of Cell Science2010
18483766Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands.J Comput Aided Mol Des2009
19502066Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.Bioorg Med Chem2009
19741708Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.Nature2009
19033212Phospholipase C isozymes as effectors of Ras superfamily GTPases.Journal of Lipid Research2009
19572637Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition.Bioconjug Chem2009
19339661Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems.Journal of Pharmacology and Experimental Therapeutics2009
19419868Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.Bioorg Med Chem Lett2009
19103595Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.Journal of Biological Chemistry2009
19759354Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.Mol Pharmacol2009
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