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Author Details

Francisca Vazquez
Broad Institute of MIT and Harvard
1979
115
62
PMIDPaper TitleJournal TitlePublished Year
36576405A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.Cancer Discov2023
37612728Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal.Genome Biol2023
37509239Clinicopathological Profiles Associated with Discordant <i>RAS</i> Mutational Status between Liquid and Tissue Biopsies in a Real-World Cohort of Metastatic Colorectal Cancer.Cancers (Basel)2023
37024492Mapping the landscape of genetic dependencies in chordoma.Nat Commun2023
37237081Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.Nat Cancer2023
35085500Sparse dictionary learning recovers pleiotropy from human cell fitness screens.Cell Syst2022
35437317Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.Nat Cancer2022
35822563Computational estimation of quality and clinical relevance of cancer cell lines.Mol Syst Biol2022
35365656Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.Nat Commun2022
35776130A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer.Clin Cancer Res2022
36305736BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.Cancer Discov2022
36127368Systematic profiling of conditional degron tag technologies for target validation studies.Nat Commun2022
33417832An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence.Cancer Cell2021
33883167Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.Cancer Discov2021
33534641Predicting cell health phenotypes using image-based morphology profiling.Mol Biol Cell2021
33782565Bridging the gap between cancer cell line models and tumours using gene expression data.Br J Cancer2021
33753930A first-generation pediatric cancer dependency map.Nat Genet2021
33500573Cancer research needs a better map.Nature2021
34857952Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.Nat Genet2021
34853037Are CRISPR Screens Providing the Next Generation of Therapeutic Targets?Cancer Res2021
34930405Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects.Genome Biol2021
34129824STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.Cancer Cell2021
34099491Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival.Cancer Res2021
34260938Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.Cell Rep2021
33406420Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.Cell Rep2021
32424350Cas9 activates the p53 pathway and selects for p53-inactivating mutations.Nat Genet2020
31929186H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP.J Clin Invest2020
33326793Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.Cell Rep2020
32855387Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.Nat Commun2020
32587373Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations.Nat Genet2020
32696566The Cancer Dependency Map enables drug mechanism-of-action investigations.Mol Syst Biol2020
32613204Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.Nat Cancer2020
30664779Small-molecule targeting of brachyury transcription factor addiction in chordoma.Nat Med2019
31862961Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.Nat Commun2019
31558726Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors.Nat Commun2019
31577942Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.Cell Rep2019
31461650Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.Cell Rep2019
30898838Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers.Cancer Res2019
31015438BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors.Nat Commun2019
31068703The landscape of cancer cell line metabolism.Nat Med2019
31068700Next-generation characterization of the Cancer Cell Line Encyclopedia.Nature2019
30971823WRN helicase is a synthetic lethal target in microsatellite unstable cancers.Nature2019
30755442MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors.Cancer Res2019
31160565Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.Nat Commun2019
29202477CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.J Clin Invest2018
30127528Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.Nat Genet2018
30045945Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in <i>TP53</i> wild-type Ewing sarcoma.J Exp Med2018
29955178Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.Nat Genet2018
30089904Genetic and transcriptional evolution alters cancer cell line drug response.Nature2018
30224644Mutational processes shape the landscape of TP53 mutations in human cancer.Nat Genet2018
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Collaborators

William C Hahn
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 57
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 49
David E Root
Broad Institute of Harvard and MIT
Co-authored papers 32
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 25
Jesse S Boehm
Broad Institute of Harvard and MIT
Co-authored papers 24
Barbara A Weir
Janssen Research and Development LLC
Co-authored papers 22
Kimberly Stegmaier
Dana-Farber Cancer Institute
Co-authored papers 17
Glenn S Cowley
Broad Institute of Harvard and MIT
Co-authored papers 14
William R Sellers
Co-authored papers 13
Charles W M Roberts
Co-authored papers 12
Brenton R Paolella
Co-authored papers 12
Levi A Garraway
Broad Institute of Harvard and MIT
Co-authored papers 11
Mahmoud Ghandi
Co-authored papers 11
Matthew Meyerson
Broad Institute
Co-authored papers 9
Andrew D Cherniack
Dana-Farber Cancer Institute
Co-authored papers 9
Rameen Beroukhim
Co-authored papers 9
John G Doench
Co-authored papers 9
Gad Getz
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 8
Guillaume Kugener
Keck School of Medicine of the University of California los angeles
Co-authored papers 8
Federica Piccioni
Co-authored papers 8
Gregory V Kryukov
Co-authored papers 7
James E Bradner
Co-authored papers 6
Gabriela Alexe
Dana-Farber Cancer Institute
Co-authored papers 6
Stuart L Schreiber
Broad Institute
Co-authored papers 5
Nathanael S Gray
Harvard Medical School
Co-authored papers 5
Peter N Devreotes
Co-authored papers 5
Paul A Clemons
Broad Institute
Co-authored papers 5
Jill P Mesirov
University of California San Diego
Co-authored papers 4
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 4
Pablo Tamayo
University of California San Diego
Co-authored papers 4
Release 1.2