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Author Details

Colm J Ryan
University College Dublin
1999
45
20
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36890003Targeting synthetic lethal paralogs in cancer.Trends Cancer2023
37963083Paralog dispensability shapes homozygous deletion patterns in tumor genomes.Mol Syst Biol2023
37978128Exploiting Cancer Synthetic Lethality in Cancer-Lessons Learnt from PARP Inhibitors.Cancer Treat Res2023
38036785Complex synthetic lethality in cancer.Nat Genet2023
38035131Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity.NAR Cancer2023
37169592Antibody reliability influences observed mRNA-protein correlations in tumour samples.Life Sci Alliance2023
36160043Experimental reproducibility limits the correlation between mRNA and protein abundances in tumor proteomic profiles.Cell Rep Methods2022
34529928Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines.Cell Syst2021
33882379Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinoma.Cancer Treat Res Commun2021
33591981Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.PLoS Genet2021
32463358Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.Elife2020
31980649Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS<sup>G13D</sup>.Nat Commun2020
30373918Cells Lacking the <i>RB1</i> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.Cancer Discov2019
31652272Paralog buffering contributes to the variable essentiality of genes in cancer cell lines.PLoS Genet2019
28733404High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast <i>Schizosaccharomyces pombe</i>.Cold Spring Harb Protoc2018
29915391Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.Oncogene2018
30131505Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.Sci Rep2018
30006631Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.Sci Rep2018
30292351Synthetic Lethality and Cancer - Penetrance as the Major Barrier.Trends Cancer2018
30366987Systems biology: old news or new stimulus for biochemistry.Essays Biochem2018
29610289E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.Cancer Discov2018
29344886Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels.Methods Mol Biol2018
28733406Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.Cold Spring Harb Protoc2018
28711281CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.Cell Syst2017
28446597The histone variant H2A.Z promotes splicing of weak introns.Genes Dev2017
29032073A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.Cell Syst2017
26947069Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Cell Rep2016
27958275ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.Nat Commun2016
25765234Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression.BMC Genomics2015
25825871Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast.PLoS Genet2015
24565511Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.Cell Rep2014
25203319DAISY: picking synthetic lethals from cancer genomes.Cancer Cell2014
25302077Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.Genome Med2014
23746449Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation.Cell Rep2013
24360963Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.Cell Rep2013
24197012High-resolution network biology: connecting sequence with function.Nat Rev Genet2013
23661563All or nothing: protein complexes flip essentiality between distantly related eukaryotes.Genome Biol Evol2013
22681890Hierarchical modularity and the evolution of genetic interactomes across species.Mol Cell2012
23209445The yeast SR-like protein Npl3 links chromatin modification to mRNA processing.PLoS Genet2012
22821457Comparative interaction networks: bridging genotype to phenotype.Adv Exp Med Biol2012
21605386Improved functional overview of protein complexes using inferred epistatic relationships.BMC Syst Biol2011
21791612Key functional regions in the histone variant H2A.Z C-terminal docking domain.Mol Cell Biol2011
21877290Imputing and predicting quantitative genetic interactions in epistatic MAPs.Methods Mol Biol2011
20406472Missing value imputation for epistatic MAPs.BMC Bioinformatics2010
10541070Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results.J Biomech1999
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Collaborators

Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 16
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 6
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 6
Alan Ashworth
UCSF Helen Diller Family Comprehensive Cancer Center
Co-authored papers 6
Derek Greene
University College Dublin (UCD) School of Computer Science, University College Dublin
Co-authored papers 5
Gerard Cagney
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 5
P??draig Cunningham
University College Dublin
Co-authored papers 5
Jiewei Xu
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 4
Christine Guthrie
University of California san francisco
Co-authored papers 4
Sandra J Strauss
University College London, Cancer Institute
Co-authored papers 3
Kristin L Patrick
Texas A&M University School of Medicine
Co-authored papers 3
Michael-Christopher Keogh
EpiCypher Inc.
Co-authored papers 3
Winfried Edelmann
Albert Einstein College of Medicine
Co-authored papers 3
Hyun-Soo Kim
Wonju Severance Christian Hospital
Co-authored papers 3
Joseph I Kliegman
University of California san francisco
Co-authored papers 2
Rahul Kumar
Roswell Park Comprehensive Cancer Center
Co-authored papers 2
Edgar Hartsuiker
North West Cancer Research Institute, Bangor University
Co-authored papers 2
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 2
David J Adams
Wellcome Sanger Institute
Co-authored papers 2
Kelly E Nissen
University of California san francisco
Co-authored papers 2
Elena Tosti
Albert Einstein College of Medicine
Co-authored papers 2
Harlizawati Jahari
Co-authored papers 2
Kevan M Shokat
University of California San Francisco
Co-authored papers 2
Kevin G Hardwick
Institute of Cell Biology, University of Edinburgh
Co-authored papers 1
Aude Gu??nol??
CNRS, Universite de Toulouse
Co-authored papers 1
Tracy L Kress
The College of New Jersey
Co-authored papers 1
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 1
James E Haber
Brandeis University
Co-authored papers 1
Eric E Bouhassira
Albert Einstein College of Medicine
Co-authored papers 1
Joseph A Katakowski
Pfizer Inc.
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Release 1.2