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Author Details

Toshio Kitamura
The University of Tokyo.
1984
376
81
PMIDPaper TitleJournal TitlePublished Year
36453131IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia.EMBO Mol Med2023
37714156Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment.Cell Rep2023
37522388Identification of compounds that preferentially suppress the growth of T-cell acute lymphoblastic leukemia-derived cells.Cancer Sci2023
37793857[Novel therapeutic strategy for targeting chronic myeloid leukemia stem cells via IRAK1/4 inhibition].Rinsho Ketsueki2023
37500075The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1-dependent leukemia cells.FEBS J2023
37464069SETBP1 is dispensable for normal and malignant hematopoiesis.Leukemia2023
37462944TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.J Exp Med2023
35022428Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.Nat Commun2022
35545056MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.Cell Rep2022
35644277RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias.Exp Hematol2022
35752644Changes in the proportion of anemia among young women after the Great East Japan Earthquake: the Fukushima health management survey.Sci Rep2022
35941268Mechanisms involved in hematopoietic stem cell aging.Cell Mol Life Sci2022
36042201Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.Nat Commun2022
35133065CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression.Cancer Sci2022
34921840A multiplex RT-PCR assay combined with co-extraction of DNA and RNA for simultaneous detection of TYLCV and ToCV in whitefly.J Virol Methods2022
35152350UBC9 inhibits myeloid differentiation in collaboration with AML1-MTG8.Int J Hematol2022
35237470Profiles of anemia in adolescent students with sports club membership in an outpatient clinic setting: a retrospective study.PeerJ2022
33045065Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal.J Exp Med2021
33758188Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.Nat Commun2021
34903756CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations.Sci Rep2021
34433054A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells.Cell Rep2021
34328684Clonal hematopoiesis and associated diseases: A review of recent findings.Cancer Sci2021
34062388Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain.Biochem Biophys Res Commun2021
33431855Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.Nat Commun2021
32492700HHEX promotes myeloid transformation in cooperation with mutant ASXL1.Blood2020
32089543PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.Leukemia2020
32997997Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.Cell Rep2020
32910995Efficacy of tyrosine kinase inhibitors on a mouse chronic myeloid leukemia model and chronic myeloid leukemia stem cells.Exp Hematol2020
30647146The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment.Sci Signal2019
31653912Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.Nat Commun2019
31851939Discrimination of Dormant and Active Hematopoietic Stem Cells by G<sub>0</sub> Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.Cell Rep2019
31280414Epigenetic abnormalities and therapies for hematological malignancies.Int J Hematol2019
31332161A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.Cell Death Dis2019
30927018The role of ASXL1 in hematopoiesis and myeloid malignancies.Cell Mol Life Sci2019
30944097NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis.Blood Adv2019
31160638Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.Sci Rep2019
30515738Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms.Int J Hematol2019
28720764High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis.Leukemia2018
30013160Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.Nat Commun2018
29921692Recurrent <i>RARB</i> Translocations in Acute Promyelocytic Leukemia Lacking <i>RARA</i> Translocation.Cancer Res2018
29844322Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells.Sci Rep2018
30323341Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance.Nat Immunol2018
30479367Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.Sci Rep2018
30367089ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation.Sci Rep2018
30309654The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program.Biochem Biophys Res Commun2018
30443287ASXL1 as a critical regulator of epigenetic marks and therapeutic potential of mutated cells.Oncotarget2018
29556021A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.Leukemia2018
29643185Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.J Exp Med2018
29362445Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice.Sci Rep2018
29358324The CD300e molecule in mice is an immune-activating receptor.J Biol Chem2018
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Collaborators

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Shinshu University
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Co-authored papers 28
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Universite de Strasbourg, CNRS
Co-authored papers 28
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Indian Institute of Science Education and Research Pune
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Jacek Biesiada
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Aroop Sircar
Co-authored papers 28
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Co-authored papers 28
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Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO ABCD)
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Lancaster University
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Garnet Navarro
Universidad Antonio Narino
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Brandi M Wynne
University of Utah
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Hyunwoo Kim
Korea University
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Boris Ma??ek
Interfaculty Institute for Cell Biology, University of Tubingen
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Fumio Nakahara
Graduate School of Medicine, The University of Tokyo
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Eiliv Lund
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Fr??d??ric Dallaire
Centre de recherche du Centre hospitalier universitaire de Sherbrooke
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Yuki Nagai
Co-authored papers 17
Michael Henke
Medical Center, University of Freiburg
Co-authored papers 16
Michael Holder
Center for Metagenomics and Microbiome Research, Baylor College of Medicine
Co-authored papers 12
Fan Zhang
Institute of High Energy Physics (IHEP), Chinese Academy of Sciences
Co-authored papers 7
Atsushi Iwama
Co-authored papers 6
Seishi Ogawa
Kyoto University
Co-authored papers 5
Nobuhiro Nakano
Co-authored papers 5
Garry P Nolan
Stanford University School of Medicine
Co-authored papers 4
Takashi Kadowaki
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Hiromitsu Nakauchi
Advanced Research Institute, Tokyo Medical and Dental University
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Tatsuhiro Shibata
Kurume University School of Medicine
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Haruhiko Koseki
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Release 1.2