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| 37275873 | The human Stat1 gain-of-function T385M mutation causes expansion of activated T-follicular helper/T-helper 1-like CD4 T cells and sex-biased autoimmunity in specific pathogen-free mice. | | 2023 |
| 36051751 | CDK4: a master regulator of the cell cycle and its role in cancer. | Genes and Cancer | 2022 |
| 35798734 | TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis. | Nature Communications | 2022 |
| 34959389 | Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. | Pharmaceutics | 2021 |
| 34092233 | Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. | Molecular Cancer | 2021 |
| 33875789 | Correction: critical interactions between TGF-β signaling/ELF, and E-cadherin/β-catenin mediated tumor suppression. | Oncogene | 2021 |
| 34344863 | Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease. | Nature Communications | 2021 |
| 32619468 | A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent. | Molecular Cell | 2020 |
| 30701029 | Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia. | Oncotarget | 2018 |
| 30100187 | Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. | Cell | 2018 |
| 28215825 | Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia. | Cell Stem Cell | 2017 |
| 28643779 | Drugging the 'undruggable' cancer targets. | Nat Rev Cancer | 2017 |
| 29234486 | JNK-signaling: A multiplexing hub in programmed cell death. | Genes and Cancer | 2017 |
| 27655714 | Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. | Oncotarget | 2016 |
| 27104980 | A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling. | Cell | 2016 |
| 27144834 | Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations. | Oncotarget | 2016 |
| 26873845 | Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. | Cancer Research | 2016 |
| 26762835 | Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). | Bioorganic and Medicinal Chemistry | 2016 |
| 26174628 | Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas. | Leukemia | 2016 |
| 26468278 | JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1. | Journal of Biological Chemistry | 2015 |
| 25681612 | Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteins. | Journal of Biochemistry | 2015 |
| 24835034 | Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140. | European Journal of Cancer | 2014 |
| 24417566 | Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). | Journal of Medicinal Chemistry | 2014 |
| 24529717 | Rigosertib is a more effective radiosensitizer than cisplatin in concurrent chemoradiation treatment of cervical carcinoma, in vitro and in vivo. | International Journal of Radiation Oncology Biology Physics | 2014 |
| 24568969 | Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models. | Molecular Cancer Therapeutics | 2014 |
| 24516162 | B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. | Proc Natl Acad Sci U S A | 2014 |
| 25103188 | Myb permits multilineage airway epithelial cell differentiation. | Stem Cells | 2014 |
| 23124440 | Combined administration of rituximab and on 013105 induces apoptosis in mantle cell lymphoma cells and reduces tumor burden in a mouse model of mantle cell lymphoma. | Clinical Cancer Research | 2013 |
| 23995446 | Understanding the temporal sequence of genetic events that lead to prostate cancer progression and metastasis. | Proceedings of the National Academy of Sciences of the United States of America | 2013 |
| 23750455 | Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. | Journal of Medicinal Chemistry | 2013 |
| 23182713 | A novel role of the scaffolding protein JLP in tuning CD40-induced activation of dendritic cells. | Immunobiology | 2013 |
| 23386308 | Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent. | Organic and Biomolecular Chemistry | 2013 |
| 23180160 | Integrated pharmacokinetic-driven approach to screen candidate anticancer drugs for brain tumor chemotherapy. | AAPS Journal | 2013 |
| 23261806 | Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. | Journal of Pharmaceutical and Biomedical Analysis | 2013 |
| 23505494 | ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway. | PLoS ONE | 2013 |
| 23084747 | An in vivo functional screen uncovers miR-150-mediated regulation of hematopoietic injury response. | Cell Reports | 2012 |
| 22587519 | (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies. | Journal of Medicinal Chemistry | 2012 |
| 22643351 | A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. | Gastroenterology | 2012 |
| 22383114 | Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues. | Investigational New Drugs | 2012 |
| 22918254 | Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice. | Cell Cycle | 2012 |
| 22678771 | Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybonâ¿¢) and ON013105, for brain tumor chemotherapy. | Pharm Res | 2012 |
| 23634254 | CDK4: A Key Player in the Cell Cycle, Development, and Cancer. | Genes and Cancer | 2012 |
| 23226582 | The ins and outs of bcr-abl inhibition. | Genes and Cancer | 2012 |
| 21646468 | Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation. | Cancer Research | 2011 |
| 21472140 | Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein. | Neoplasia | 2011 |
| 21520178 | Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer. | Hepatology | 2011 |
| 21812421 | Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. | Journal of Medicinal Chemistry | 2011 |
| 21880454 | Application of a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to the pharmacokinetics of ON01910 in brain tumor-bearing mice. | J Pharm Biomed Anal | 2011 |
| 21779423 | Editorial. | Genes and Cancer | 2010 |
| 20703083 | Cooperativity of Cdk4R24C and Ras in melanoma development. | Cell Cycle | 2010 |