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Author Details

Manfred Koegl
Boehringer Ingelheim RCV GmbH & Co. KG
1993
47
33
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36216795A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.Nat Commun2022
34575120Mitotic Arrest-Deficient 2 Like 2 (MAD2L2) Interacts with <i>Escherichia coli</i> Effector Protein EspF.Life (Basel)2021
33799000Transforming targeted cancer therapy with PROTACs: A forward-looking perspective.Curr Opin Pharmacol2021
32180900Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.Oncotarget2020
32047042Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.Proc Natl Acad Sci U S A2020
30540463Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.J Med Chem2019
31267096Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.Nat Chem Biol2019
31178587BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.Nat Chem Biol2019
31332011Drugging an undruggable pocket on KRAS.Proc Natl Acad Sci U S A2019
30739444Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions.J Med Chem2019
29177859Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER).Methods Mol Biol2018
28930682Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.Cell Rep2017
26914985Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.J Med Chem2016
27376689Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition.Nat Chem Biol2016
25926482TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis.Plant Physiol2015
25519916The EHEC-host interactome reveals novel targets for the translocated intimin receptor.Sci Rep2014
23950709A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.PLoS Pathog2013
23996247Analysis of protein-protein interactions using LUMIER assays.Methods Mol Biol2013
23996246A high-throughput yeast two-hybrid protocol to determine virus-host protein interactions.Methods Mol Biol2013
22218855High-throughput yeast two-hybrid screening of complex cDNA libraries.Methods Mol Biol2012
22972877F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.Circ Res2012
21131973CEP152 is a genome maintenance protein disrupted in Seckel syndrome.Nat Genet2011
21875965Comparative analysis of EspF variants in inhibition of Escherichia coli phagocytosis by macrophages and inhibition of E. coli translocation through human- and bovine-derived M cells.Infect Immun2011
19674966A community standard format for the representation of protein affinity reagents.Mol Cell Proteomics2010
20847312Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.Circ Res2010
20622827Minimum information about a protein affinity reagent (MIAPAR).Nat Biotechnol2010
20093627Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.Circ Res2010
19730696Evolutionarily conserved herpesviral protein interaction networks.PLoS Pathog2009
17311814Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.Nucleic Acids Res2007
18218650Improving yeast two-hybrid screening systems.Brief Funct Genomic Proteomic2007
17933688Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators.Drug Discov Today2007
16354658A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.J Biol Chem2006
15604093Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.Mol Cell Proteomics2005
12529392Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.Mol Cell Biol2003
12738764Computer-assisted generation of a protein-interaction database for nuclear receptors.Mol Endocrinol2003
11805086Elucidation of an archaeal replication protein network to generate enhanced PCR enzymes.J Biol Chem2002
10089879A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.Cell1999
8922277Role of the ubiquitin/proteasome system in regulated protein degradation in Saccharomyces cerevisiae.Biol Chem1996
7730365Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors.J Biol Chem1995
8570183Structural requirements for the efficient regulation of the Src protein tyrosine kinase by Csk.Oncogene1995
7823926DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.Mol Cell Biol1995
7524477Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85.Biochem J1994
8090789The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.Proc Natl Acad Sci U S A1994
7980442Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.Biochem J1994
7687537Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.EMBO J1993
7689281Generation of a temperature-sensitive cSRC.Virology1993
8049488The Src family of protein tyrosine kinases: regulation and functions.Dev Suppl1993
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Collaborators

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Co-authored papers 9
Center for the Study of Biological Complexity, Virginia Commonwealth University
Co-authored papers 3
University of Edinburgh
Co-authored papers 3
KTH Royal Institute of Technology
Co-authored papers 2
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Co-authored papers 2
Lund University
Co-authored papers 2
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 2
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Co-authored papers 2
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EMBL's European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 2
Institute of Informatics, Ludwig-Maximilians-Universitat Munchen
Co-authored papers 2
Ludwig-Maximilians-Universitat Munchen
Co-authored papers 2
Oslo University Hospital
Co-authored papers 2
Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB
Co-authored papers 2
Co-authored papers 2
Royal Institute of Technology
Co-authored papers 1
Institut de Genetique Medicale d'Alsace, Hopitaux Universitaires de Strasbourg
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Max-von-Pettenkofer Institute, Ludwig-Maximilians-University (LMU) Munich
Co-authored papers 1
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Vanderbilt University Medical Center
Co-authored papers 1
Office of Cancer Clinical Proteomics Research, National Cancer Institute
Co-authored papers 1
National Institutes of Health
Co-authored papers 1
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Wihuri Research Institute
Co-authored papers 1
Stanford Center for Biomedical Informatics Research, Stanford University
Co-authored papers 1
Germany Institute of Systems Biology, Shanghai University
Co-authored papers 1
Newcastle University
Co-authored papers 1
University Clinic for Swine, University of Veterinary Medicine Vienna
Co-authored papers 1