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Author Details

Shireen Vali
Cellworks Group Inc.
1994
57
23
PMIDPaper TitleJournal TitlePublished Year
34146587Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades.Eur J Pharmacol2021
34994595Computational Biological Modeling Identifies PD-(L)1 Immunotherapy Sensitivity Among Molecular Subgroups of <i>KRAS</i>-Mutated Non-Small-Cell Lung Cancer.JCO Precis Oncol2021
34580286Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.Cell Death Discov2021
32417407Prediction of Outcomes with a Computational Biology Model in Newly Diagnosed Glioblastoma Patients Treated with Radiation Therapy and Temozolomide.Int J Radiat Oncol Biol Phys2020
30641417Computational modeling of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) to identify personalized therapy using genomics.Leuk Res2019
31350446Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer.Sci Rep2019
31208955A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients.Blood Adv2019
31009835Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.Leuk Res2019
31103719A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression.Cancer Lett2019
30642575Predicting response to BET inhibitors using computational modeling: A BEAT AML project study.Leuk Res2019
29649990Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.BMC Cancer2018
29543996Human beta defensin 3 alters matrix metalloproteinase production in human dendritic cells exposed to Porphyromonas gingivalis hemagglutinin B.J Periodontol2018
29486723Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy.BMC Cancer2018
27855285Computational drug treatment simulations on projections of dysregulated protein networks derived from the myelodysplastic mutanome match clinical response in patients.Leuk Res2017
28756882Cell genomics and immunosuppressive biomarker expression influence PD-L1 immunotherapy treatment responses in HNSCC-a computational study.Oral Surg Oral Med Oral Pathol Oral Radiol2017
27056884Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines.Oncotarget2016
28239565PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression.Transl Cancer Res2016
27688163Predicting PD-L1 expression on human cancer cells using next-generation sequencing information in computational simulation models.Cancer Immunol Immunother2016
25638213Personalization of cancer treatment using predictive simulation.J Transl Med2015
26430964Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.Oncotarget2015
23765383β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.Mol Carcinog2014
25093497In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.Br J Cancer2014
24847381Predictive simulation approach for designing cancer therapeutic regimens with novel biological mechanisms.J Cancer2014
24884660In silico modeling predicts drug sensitivity of patient-derived cancer cells.J Transl Med2014
24473528Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.Sci Rep2014
24405121PI3KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance.Br J Haematol2014
23390582Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus.Sci Rep2013
24124799Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses.Expert Rev Anti Infect Ther2013
23848338Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.Br J Pharmacol2013
23671273Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts.FASEB J2013
23739266Effectiveness of a polyamide film releasing lactic acid on the growth of E. coli O157:H7, Enterobacteriaceae and Total Aerobic Count on vacuum-packed beef.Meat Sci2013
21792937Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.J Cell Physiol2012
22992727Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.J Biol Chem2012
22207758Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.J Biol Chem2012
21261709Solid pseudopapillary tumor and wnt signaling pathway ... Way to go!?J Gastroenterol Hepatol2011
22056602Dynamic modeling of α-synuclein aggregation in dopaminergic neuronal system indicates points of neuroprotective intervention: experimental validation with implications for Parkinson's therapy.Neuroscience2011
21880153Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.Mol Cancer2011
21640718Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: a novel approach for overcoming resistance in anticancer treatment.Eur J Pharmacol2011
21664055Quality traits of wild boar mould-ripened salami manufactured with different selections of meat and fat tissue, and with and without bacterial starter cultures.Meat Sci2011
21465181Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice.J Mol Med (Berl)2011
21506956Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.Br J Pharmacol2011
21131551Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.Clin Cancer Res2011
19685055Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line.Cancer Chemother Pharmacol2010
21918631A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli.Adv Appl Bioinform Chem2010
20227282Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease.Bioorg Med Chem2010
20111699A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor.PLoS One2010
20371718Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.Mol Cancer Ther2010
19856130Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.Syst Synth Biol2010
18166164Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies.Free Radic Biol Med2008
18761401Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.Free Radic Biol Med2008
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Collaborators

Taher Abbasi
Cellworks Group Inc.
Co-authored papers 31
Leylah M Drusbosky
College of Medicine, University of Florida
Co-authored papers 5
Anay Talawdekar
Cellworks Research India Pvt Ltd
Co-authored papers 5
Christopher R Cogle
College of Medicine, University of Florida
Co-authored papers 5
Robinson Vidva
Cellworks Research India Pvt. Ltd
Co-authored papers 4
Ashish Agrawal
Cellworks Research India Pvt. Ltd
Co-authored papers 3
Terry A Braun
University of Iowa
Co-authored papers 2
Kimberly E Hawkins
College of Medicine, University of Florida
Co-authored papers 2
Ravi Vij
Co-authored papers 2
Timothy A Chan
Cleveland Clinic.
Co-authored papers 2
Ruby Yun-Ju Huang
National Taiwan University College of Medicine
Co-authored papers 1
Patrick Y Wen
Co-authored papers 1
Brian J Druker
Oregon Health & Science University
Co-authored papers 1
Erliang Zeng
College of Dentistry, University of Iowa
Co-authored papers 1
Bijal Shah
Moffitt Cancer Center
Co-authored papers 1
Cristina E Tognon
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Amanda Winters
University of Colorado School of Medicine
Co-authored papers 1
Diana Abbott
Center for Innovative Design and Analysis, University of Colorado, Aurora CO.
Co-authored papers 1
Daniel A Pollyea
University of Colorado Division of Hematology
Co-authored papers 1
Chandan Kumar-Sinha
Co-authored papers 1
Veronica Clavijo Jordan
Harvard Medical School
Co-authored papers 1
Vijayashree P Shyamasundar
Cellworks Research India Pvt. Ltd
Co-authored papers 1
Saji Gera
Cellworks Research India Pvt. Ltd
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Dayu Teng
Co-authored papers 1
Anjanasree V Lakshminarayana
Cellworks Research India Pvt. Ltd
Co-authored papers 1
Brett M Stevens
University of Colorado School of Medicine
Co-authored papers 1
Stephen E Kurtz
Knight Cancer Institute, Oregon Health and Science University
Co-authored papers 1
Keith L Ligon
Co-authored papers 1
Yang Zhang
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Release 1.2