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Author Details

Gene M Shearer
1964
429
87
PMIDPaper TitleJournal TitlePublished Year
29730433The tolerogenic peptide hCDR1 immunomodulates cytokine and regulatory molecule gene expression in blood mononuclear cells of primary Sjogren's syndrome patients.Clinical Immunology2018
29512145Induction and Measurement of Cytotoxic T Lymphocyte Activity.Current Protocols in Immunology2018
26544708Curing HIV/AIDS beyond hematopoietic stem cell transplant.AIDS2015
24732038Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline.PLoS One2014
24251542Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques.AIDS Research and Human Retroviruses2014
22013040Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade.Journal of Virology2012
21876718Alloantigen-based AIDS vaccine: revisiting a "rightfully" discarded promising strategy.F1000 Medicine Reports2011
21931112Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis.Blood2011
20647411Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection.Cancer Epidemiol Biomarkers Prev2010
20887219Historical perspective on HIV⿐exposed seronegative individuals: has nature done the experiment for us?Journal of Infectious Diseases2010
20001649Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus.Autoimmunity2010
20124101TLR activation pathways in HIV-1-exposed seronegative individuals.Journal of Immunology2010
19895691Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.AIDS Research and Therapy2009
19093962Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?Journal of Internal Medicine2009
19093956Introduction: Back to basics: mucosal immunity and novel HIV vaccine concepts.Journal of Internal Medicine2009
19050384HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.AIDS2009
19131607Unsung hero Robert C. Gallo.Science2009
19299731Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.Journal of Immunology2009
19334055WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication.Environmental and Molecular Mutagenesis2009
18691036Fetal-maternal HLA-A and -B discordance is associated with placental RNase expression and anti-HIV-1 activity.Current HIV Research2008
19079217CD4+ T-cell loss and delayed expression of modulators of immune responses at mucosal sites of vaccinated macaques following SIV(mac251) infection.Mucosal Immunology2008
17916442Chronic innate immune activation as a cause of HIV-1 immunopathogenesis.Clinical Immunology2008
18390726Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.Journal of Immunology2008
18650129PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes.Clinical Immunology2008
18457922Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells.Neuroscience Letters2008
18698365HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.PLoS ONE2008
18539209The hunt for an HIV vaccine: time to rethink recent failures.Lancet, The2008
17112786HIV-1 immunopathogenesis: how good interferon turns bad.Clinical Immunology2007
17430110How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation.Current Drug Metabolism2007
17158233HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.Blood2007
17678480Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshop.AIDS Research and Human Retroviruses2007
17339444Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.J Immunol2007
17956986HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha.Proceedings of the National Academy of Sciences of the United States of America2007
17715231Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection.Journal of Virology2007
18432971Induction and measurement of cytotoxic T lymphocyte activity.Current Protocols in Immunology2006
17078484Do regulatory T-cells play a role in AIDS pathogenesis?AIDS Reviews2006
16632604Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.Proceedings of the National Academy of Sciences of the United States of America2006
16902147HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.Blood2006
16736946Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?AIDS Reviews2006
16896154CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques.Blood2006
16989616Ribonucleases in HIV type 1 inhibition: effect of recombinant RNases on infection of primary T cells and immune activation-induced RNase gene and protein expression.AIDS Research and Human Retroviruses2006
16174727Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells.Proceedings of the National Academy of Sciences of the United States of America2005
15749840The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients.Journal of Immunology2005
15585654TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells.Blood2005
15466932Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.Blood2005
16046522CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis.Blood2005
15207501Alloantigen recognition in utero: dual advantage for the fetus?Trends in Immunology2004
12598767Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition.AIDS2003
12468426B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.Blood2003
12814801The effect of IL-12 on clinical and laboratory aspects of experimental SLE in young and aging mice.Experimental Gerontology2003
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