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Author Details

Yue-Ming Li
Memorial Sloan Kettering Cancer Center
1990
144
46
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36634183Gut microbes modulate neurodegeneration.Science2023
37322156Nanosensor-based monitoring of autophagy-associated lysosomal acidification in vivo.Nat Chem Biol2023
37218456Zn(II)-catalysed enantioselective addition of alcohols and <i>tert</i>-butyl hydroperoxide to isatin-derived <i>N</i>-Boc ketimines.Chem Commun (Camb)2023
37449907γ-Secretase fanning the fire of innate immunity.Biochem Soc Trans2023
36723244Enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by Cu(II) complexes bearing binaphthyl-proline hybrid ligands.Org Biomol Chem2023
35078351Functional insight into LOAD-associated microglial response genes.Open Biol2022
35764706Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion.Mol Psychiatry2022
35729174Cyclic microchip assay for measurement of hundreds of functional proteins in single neurons.Nat Commun2022
35420796Optical Nanosensor for Intracellular and Intracranial Detection of Amyloid-Beta.ACS Nano2022
35979164Radiomic analysis based on multi-phase magnetic resonance imaging to predict preoperatively microvascular invasion in hepatocellular carcinoma.World J Gastroenterol2022
34983641Turning the tide on Alzheimer's disease: modulation of γ-secretase.Cell Biosci2022
35262173Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.Cancer Discov2022
34156424GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.J Exp Med2021
33908558Binaphthyl-prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes.Org Biomol Chem2021
34475100Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe.Clin Cancer Res2021
32432881γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.Langmuir2020
32016207Substrate interaction inhibits γ-secretase production of amyloid-β peptides.Chem Commun (Camb)2020
31911948Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.Sci Adv2020
33062181Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage.ACS Med Chem Lett2020
33343338γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors.Front Aging Neurosci2020
33479693Recent developments of small molecule γ-secretase modulators for Alzheimer's disease.RSC Med Chem2020
33237100Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes.Org Biomol Chem2020
32879487The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.Nature2020
32786303A Pentacyclic Triterpene from <i>Ligustrum lucidum</i> Targets γ-Secretase.ACS Chem Neurosci2020
32587315Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model.Sci Rep2020
32778663Author Correction: Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model.Sci Rep2020
32249070γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase.Semin Cell Dev Biol2020
32551686Direct Intramolecular Aminoboration of Allenes.Org Lett2020
30629072Metal-free oxysulfonylation and aminosulfonylation of alkenyl oximes: synthesis of sulfonylated isoxazolines and cyclic nitrones.Org Biomol Chem2019
31920620Friend, Foe or Both? Immune Activity in Alzheimer's Disease.Front Aging Neurosci2019
31463500Pd-Catalyzed decarboxylative cross-coupling reactions of epoxides with α,β-unsaturated carboxylic acids.Chem Commun (Camb)2019
31577324Iodine-mediated aminosulfonylation of alkenyl sulfonamides with sulfonyl hydrazides: synthesis of sulfonylmethyl piperidines, pyrrolidines and pyrazolines.Org Biomol Chem2019
30850537GSAP modulates γ-secretase specificity by inducing conformational change in PS1.Proc Natl Acad Sci U S A2019
30758748Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome.J Mol Neurosci2019
29733609Mn(OAc)<sub>3</sub>-Mediated Hydrotrifluoromethylation of Unactivated Alkenes Using CF<sub>3</sub>SO<sub>2</sub>Na as the Trifluoromethyl Source.J Org Chem2018
35559282Cu-catalyzed cross-coupling reactions of vinyl epoxide with organoboron compounds: access to homoallylic alcohols.RSC Adv2018
30106573Construction of 3,4-Dihydroisoquinolinones and Indanones via DTBP-Promoted Oxidative Coupling of N-Allylbenzamides with Aromatic Aldehydes.J Org Chem2018
28065657Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes.Cell Chem Biol2017
28198634Phase Composition Control in Microsphere-Supported Biomembrane Systems.Langmuir2017
28333470Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.Org Lett2017
28320827Structural and Chemical Biology of Presenilin Complexes.Cold Spring Harb Perspect Med2017
29237809The role of astrocytes in amyloid production and Alzheimer's disease.Open Biol2017
28645897Versatility of presenilin 1.Proc Natl Acad Sci U S A2017
26699370Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe.Anal Chem2016
27253220Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.ACS Chem Neurosci2016
27133790Physiological and pathological roles of the γ-secretase complex.Brain Res Bull2016
27214117Preparation of trans-2-Substituted-4-halopiperidines and cis-2-Substituted-4-halotetrahydropyrans via AlCl3-Catalyzed Prins Reaction.J Org Chem2016
26887941Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.J Biol Chem2016
26952080Benzimidazole covalent probes and the gastric H(+)/K(+)-ATPase as a model system for protein labeling in a copper-free setting.Mol Biosyst2016
25610395Complex regulation of γ-secretase: from obligatory to modulatory subunits.Front Aging Neurosci2015
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Collaborators

Hui Zheng
Baylor College of Medicine
Co-authored papers 3
Charles G Eberhart
Wilmer Eye Institute, Johns Hopkins Medical Institutions
Co-authored papers 3
Steven L Wagner
Co-authored papers 2
Daria J Hazuda
Merck & Co. Inc.
Co-authored papers 2
Rong Wang
Co-authored papers 2
Alison M Goate
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Dorit Donoviel
Translational Research Institute for Space Health
Co-authored papers 2
Phuong Nguyen
Hoag Memorial Hospital Presbyterian
Co-authored papers 2
Simon R Cherry
University of California Davis Davis
Co-authored papers 2
William Matsui
Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin
Co-authored papers 2
Philip C Wong
Co-authored papers 1
Holly Hammond
Center for Pathogen Research, University of Maryland School of Medicine
Co-authored papers 1
Xiaobing Yu
Heidelberg University
Co-authored papers 1
Akinori Tokunaga
University of Fukui
Co-authored papers 1
Kevin Kleffman
NYU School of Medicine
Co-authored papers 1
Angus C Nairn
Co-authored papers 1
Bin Zhang
Graduate School of Medicine, The University of Tokyo
Co-authored papers 1
Tong Li
Co-authored papers 1
Linzhao Cheng
Johns Hopkins University School of Medicine
Co-authored papers 1
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 1
Angelo L Vescovi
IRCCS Casa Sollievo della Sofferenza, University of Milano-Bicocca
Co-authored papers 1
Francesco DiMeco
Co-authored papers 1
Mareike Simon
Abramson Family Cancer Research Institute, Perelman School of Medicine
Co-authored papers 1
Eliezer Masliah
National Institute On Aging
Co-authored papers 1
Christopher P Austin
St. George's University Medical School
Co-authored papers 1
Geoffrey Chang
Skaggs School of Pharmacy and Pharmaceutical Sciences.
Co-authored papers 1
Kevin D Rynearson
Co-authored papers 1
Kelly V Ruggles
Co-authored papers 1
Bhavneet Bhinder
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Release 1.2