Author details

Full Name

Robert M Hoffman

Affiliation

ORCID

Career Start Year

1971

Papers

1099

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37500137	Long-lasting Limb Salvage After Malignant Femoral-Bone Tumor Resection Reconstructed With a Thin-mantle Titanium Stem Fixated With Cement.		2023
36265256	Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.	Phytomedicine	2023
36057899	Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model.	Ann Surg Oncol	2023
36056196	ASO Visual Abstract: Proof of Principle of Combining Fluorescence-Guided Surgery with Photoimmunotherapy to Improve the Outcome of Pancreatic Cancer Therapy in an Orthotopic Mouse Model.	Ann Surg Oncol	2023
37751865	Targeting Methionine Addiction of Cancer Cells with Methioninase.		2023
37652473	Rapid Reduction of CEA and Stable Metastasis in an -mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment		2023
37643781	Methionine Restriction Increases Exosome Production and Secretion in Breast Cancer Cells.		2023
37573425	SLC26A3/NHERF2-IÎºB/NFÎºB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer.		2023
37772554	High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy.		2023
36593017	Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.		2023
36586158	Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer.		2023
37405226	Bioinformatics Analysis of Immune Infiltration In Endometrial Carcinoma Tumors and its Relationship With Prognosis.		2023
36900282	The Mucin Family of Proteins: Candidates as Potential Biomarkers for Colon Cancer.	Cancers (Basel)	2023
36585181	Recombinant Oral Methioninase (o-rMETase) Combined With Oxaliplatinum Plus 5-Fluorouracil Improves Survival of Mice With Massive Colon-Cancer Peritoneal Carcinomatosis.		2023
37400145	Targeting Autophagy With the Synergistic Combination of Chloroquine and Rapamycin as a Novel Effective Treatment for Well-differentiated Liposarcoma.		2023
36768257	Superiority of [C]methionine over [F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer.		2023
36638123	Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model.		2023
37320867	Colon-cancer liver metastasis is effectively targeted by recombinant methioninase (rMETase) in an orthotopic mouse model.	Tissue Cell	2023
36870694	Oncogenes and Methionine Addiction of Cancer: Role of .		2023
37185743	Specific Targeting and Labeling of Colonic Polyps in <i>CPC-APC</i> Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer.	Curr Issues Mol Biol	2023
37369517	Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression.		2023
37369464	Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer.		2023
37241027	Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study.		2023
37301544	Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing in C57BL/6 mice.		2023
37168964	Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment.		2023
36604411	TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer.		2023
37540977	PEGylated Fluorescent Anti-carcinoembryonic Antigen Antibody Labels Colorectal Cancer Tumors in Orthotopic Mouse Models.	J Surg Res	2023
37500146	Positive Circumferential Resection Margin in Rectal Cancer Is a Robust Predictor of Poor Long-term Prognosis With Clinicopathological Bias Between Groups Compensated by Propensity-score Matching Analysis.		2023
35053365	Fluorescence Molecular Targeting of Colon Cancer to Visualize the Invisible.	Cells	2022
35715267	Anti-mucin 4 fluorescent antibody brightly targets colon cancer in patient-derived orthotopic xenograft mouse models: A proof-of-concept study for future clinical applications.	Am J Surg	2022
35530299	ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage.	Am J Cancer Res	2022
36309387	Chloroquine Combined With Rapamycin Arrests Tumor Growth in a Patient-derived Orthotopic Xenograft (PDOX) Mouse Model of Dedifferentiated Liposarcoma.	In Vivo	2022
36309364	Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model.	In Vivo	2022
35896248	Long-term Stable Disease in a Rectal-cancer Patient Treated by Methionine Restriction With Oral Recombinant Methioninase and a Low-methionine Diet.	Anticancer Research	2022
36288875	Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model.	Anticancer Research	2022
35434545	Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.	iScience	2022
36003796	Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application.	Frontiers in Oncology	2022
35430564	Deletion of Highly Sensitizes Osteosarcoma Cells to Methionine Restriction With Recombinant Methioninase.	Cancer Genomics and Proteomics	2022
36075909	Pro-senescence neddylation inhibitor combined with a senescence activated Î²-galactosidase prodrug to selectively target cancer cells.	Signal Transduction and Targeted Therapy	2022
35625638	Fluorescent Anti-CEA Nanobody for Rapid Tumor-Targeting and Imaging in Mouse Models of Pancreatic Cancer.	Biomolecules	2022
35489727	Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease.	Anticancer Research	2022
35489720	Guanylate-binding Protein 2 Expression Is Associated With Poor Survival and Malignancy in Clear-cell Renal Cell Carcinoma.	Anticancer Research	2022
36271542	Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay.		2022
36138026	Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation.	Cell Death and Disease	2022
35738622	Non-invasively Imageable Tibia-tumor-fragment Implantation Experimental-bone-metastasis Mouse Model of GFP-expressing Prostate Cancer.	In Vivo	2022
35738609	The First Mouse Model of Meckel's Diverticulum Carcinoma.	In Vivo	2022
35738603	Obesity Strongly Promotes Growth of Mouse MC38 Colon Cancer in an Orthotopic-syngeneic C57BL/6 Mouse Model.	In Vivo	2022
35927078	Proof of concept of improved fluorescence-guided surgery of colon cancer liver metastasis using color-coded imaging of a tumor-labeling fluorescent antibody and indocyanine green restricted to the adjacent liver segment.	Surgery	2022
36192016	Micro RNA miR-1303 Promotion of Proliferation, Migration and Invasion of Human Liver Cancer Cells Is Enhanced by Low Talin 1 (TLN1) Expression.	Anticancer Research	2022
36191994	Long-chain Non-coding RNA MIR4435-2HG Expression Correlates With Size of Intestinal Polyps in Children and With Metastasis of Colon Cancer.	Anticancer Research	2022