Author details

Full Name

Timothy M Frayling

Affiliation

ORCID

Career Start Year

1997

Papers

380

H Index

114

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37503126	Understanding the genetic complexity of puberty timing across the allele frequency spectrum.	medRxiv	2023
36048866	Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk.	Hum Mol Genet	2023
37604891	Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.	Nat Commun	2023
37733769	Identification and analysis of individuals who deviate from their genetically-predicted phenotype.	PLoS Genet	2023
37632325	Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review.		2023
37784116	Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records.		2023
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37410385	Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.	Int J Epidemiol	2023
37280435	Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.	Diabetologia	2023
37133737	Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study.	Eur J Epidemiol	2023
36693378	Loci for insulin processing and secretion provide insight into type 2 diabetes risk.	Am J Hum Genet	2023
37305903	Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis.		2023
36798216	Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion.	medRxiv	2023
36798175	Identification and analysis of individuals who deviate from their genetically-predicted phenotype.	bioRxiv	2023
35061033	Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns.		2022
35393509	Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.	Commun Biol	2022
35513483	Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.	Commun Biol	2022
35388897	Simulated distributions from negative experiments highlight the importance of the body mass index distribution in explaining depression-body mass index genetic risk score interactions.	International Journal of Epidemiology	2022
35700724	Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population.	Am J Hum Genet	2022
35583923	Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation.	eLife	2022
35436960	Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis.	BMC Med	2022
35687092	Detection and characterization of male sex chromosome abnormalities in the UK Biobank study.	Genet Med	2022
36137075	The impact of Mendelian sleep and circadian genetic variants in a population setting.	PLoS Genet	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36055212	Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies.	Am J Hum Genet	2022
35534559	Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.	Nat Genet	2022
36469092	Genomics and multimorbidity.	Age and Ageing	2022
35048991	Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis.	J Natl Cancer Inst	2022
35235652	PLIN1 Haploinsufficiency Causes a Favorable Metabolic Profile.	Journal of Clinical Endocrinology and Metabolism	2022
35246685	Corrigendum to: A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio.	Human Molecular Genetics	2022
34897462	Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.	Hum Mol Genet	2022
34475573	Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.	Nat Genet	2021
33798434	Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R.	Cell	2021
34111113	A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor.	PLoS Genetics	2021
34270736	Higher adiposity and mental health: causal inference using Mendelian randomization.	Human Molecular Genetics	2021
33563987	Genetic predictors of participation in optional components of UK Biobank.	Nat Commun	2021
33558525	Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.	Nat Commun	2021
33980691	Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.		2021
33501652	Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.	Diabetic Medicine	2021
32989287	Genome-wide association study identifies 48 common genetic variants associated with handedness.	Nat Hum Behav	2021
33184701	Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study.	Diabetologia	2021
32944759	Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.	Journal of Clinical Endocrinology and Metabolism	2021
32944759	Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.	Journal of Clinical Endocrinology and Metabolism	2021
33323478	Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.	Diabetes Care	2021
34465205	Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size.	J Am Heart Assoc	2021
34916535	Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer.	Nat Commun	2021
34729547	Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives.	Lancet Healthy Longev	2021
34561431	Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome.	Nat Commun	2021
34542646	Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile.	Diabetologia	2021
30617275	Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.	Mol Psychiatry	2020