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Author Details

Raymond J Pickles
Marsico Lung Institute, University of North Carolina-Chapel Hill
1991
93
47
PMIDPaper TitleJournal TitlePublished Year
36965846Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection.J Theor Biol2023
37159271Human T cells efficiently control RSV infection.JCI Insight2023
35040594Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial.Int Forum Allergy Rhinol2022
35378080Modeling insights into SARS-CoV-2 respiratory tract infections prior to immune protection.Biophys J2022
35074895Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.Proc Natl Acad Sci U S A2022
33276017Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19.J Control Release2021
33561864SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801.Nature2021
34013253Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections.Res Sq2021
33309815Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy.Adv Drug Deliv Rev2021
32995766Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801.Res Sq2020
31451733Precision mouse models with expanded tropism for human pathogens.Nat Biotechnol2019
26976607SARS-like WIV1-CoV poised for human emergence.Proc Natl Acad Sci U S A2016
28000669A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.Nat Commun2016
27279612A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats.J Virol2016
25302625Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis.J Pathol2015
24475177Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication.PLoS One2014
24713657RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.J Clin Invest2014
22929560Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.Mucosal Immunol2013
24362700Human airway epithelial cell cultures for modeling respiratory syncytial virus infection.Curr Top Microbiol Immunol2013
23365422Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.J Virol2013
23012413Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.Proc Natl Acad Sci U S A2012
22959894Human parainfluenza virus serotypes differ in their kinetics of replication and cytokine secretion in human tracheobronchial airway epithelium.Virology2012
20935191Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium.Am J Respir Cell Mol Biol2011
21998692A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.PLoS One2011
21986028Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.Virology2011
22164298Yeast based small molecule screen for inhibitors of SARS-CoV.PLoS One2011
21816184Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection.Virus Res2011
21625534AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis.PLoS Pathog2011
21703540NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.Immunity2011
21752418AAV-6 mediated efficient transduction of mouse lower airways.Virology2011
21508186Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.J Gen Virol2011
21106732Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential.J Virol2011
19969320Human parainfluenza virus type 2 V protein inhibits interferon production and signaling and is required for replication in non-human primates.Virology2010
20735256α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors.Hum Gene Ther2010
20719951Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures.J Virol2010
20504917Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro.J Virol2010
20139088Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.J Biol Chem2010
20139039Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys.Vaccine2010
20331639Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.Cell Microbiol2010
19010509Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge.Virology2009
19924306Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.PLoS One2009
19656891Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans.J Virol2009
19621064CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium.PLoS Biol2009
19603002Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.Mol Ther2009
19436701Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways.PLoS Pathog2009
19404494MAVS-mediated apoptosis and its inhibition by viral proteins.PLoS One2009
19362020The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.Immunity2009
19066597Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro.Mol Ther2009
19190083Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.FASEB J2009
18931053Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?Am J Physiol Lung Cell Mol Physiol2009
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Collaborators

Richard C Boucher
Co-authored papers 20
Ralph S Baric
University of North Carolina
Co-authored papers 18
Amy C Sims
The University of North Carolina at Chapel Hill
Co-authored papers 11
Eric F Donaldson
Co-authored papers 7
Susan E Burkett
Co-authored papers 6
Boyd L Yount
University of North Carolina at Chapel Hill
Co-authored papers 6
Scott H Randell
Co-authored papers 5
Mehmet Kesimer
Co-authored papers 4
Wanda K O'Neal
Co-authored papers 4
Lisa E Gralinski
University of North Carolina at Chapel Hill
Co-authored papers 4
Kimberlie A Burns
Co-authored papers 3
Alexandra Sch??fer
University of North Carolina at Chapel Hill
Co-authored papers 3
Takafumi Kato
Co-authored papers 2
Corbin D Jones
University of North Carolina at Chapel Hill
Co-authored papers 2
Edward P Browne
University of North Carolina at Chapel Hill
Co-authored papers 2
Camille Ehre
Co-authored papers 2
Vineet D Menachery
University of Texas Medical Branch
Co-authored papers 2
Brian Button
Co-authored papers 2
Casey Long
University of North Carolina at Chapel Hill
Co-authored papers 2
Rachel L Graham
University of North Carolina
Co-authored papers 2
Bronson C Wessinger
12328Vanderbilt University Medical Center
Co-authored papers 2
Sarah R Leist
University of North Carolina at Chapel Hill
Co-authored papers 2
Agathe Ceppe
Co-authored papers 2
Mark T Heise
University of North Carolina at Chapel Hill.
Co-authored papers 2
Ronit Freeman
Co-authored papers 2
Wendell G Yarbrough
University of North Carolina at Chapel Hill
Co-authored papers 1
Chien-Te K Tseng
The University of Texas Medical Branch
Co-authored papers 1
Jessica A Plante
Co-authored papers 1
Armand Bankhead
Rogel Cancer Center, University of Michigan ann arbor
Co-authored papers 1
James E Gern
University of Wisconsin School of Medicine and Public Health
Co-authored papers 1
Release 1.2