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Author Details

Geeta J Narlikar
University of California san francisco
1994
84
41
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37384669Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.Science2023
37595555Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.Mol Cell2023
37696956Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler.Nat Struct Mol Biol2023
37546986Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.bioRxiv2023
36993485Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.bioRxiv2023
35659534ATP Hydrolysis Coordinates the Activities of Two Motors in a Dimeric Chromatin Remodeling Enzyme.J Mol Biol2022
35597239A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function.Mol Cell2022
32805219Enzymatic Reactions inside Biological Condensates.J Mol Biol2021
33861943Is transcriptional regulation just going through a phase?Mol Cell2021
33556407Collaboration through chromatin: motors of transcription and chromatin structure.J Mol Biol2021
33661100HP1 proteins compact DNA into mechanically and positionally stable phase separated domains.Elife2021
33950570Generation and Biochemical Characterization of Phase-Separated Droplets Formed by Nucleic Acid Binding Proteins: Using HP1 as a Model System.Curr Protoc2021
34226739Histone dynamics play a critical role in SNF2h-mediated nucleosome sliding.Nat Struct Mol Biol2021
32437639ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA.Mol Cell2020
31965983Phase-separation in chromatin organization.J Biosci2020
31965979Topical collection on Chromatin Biology and Epigenetics.J Biosci2020
32084344Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.Cell2020
31955845Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.Cell2020
33263279Massively multiplex single-molecule oligonucleosome footprinting.Elife2020
32219172Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage.Sci Adv2020
30415948A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase.Mol Cell2019
32493764Biophysical Properties of HP1-Mediated Heterochromatin.Cold Spring Harb Symp Quant Biol2019
31184587Ion counting demonstrates a high electrostatic field generated by the nucleosome.Elife2019
31554625Chromatin topology, condensates and gene regulation: shifting paradigms or just a phase?Development2019
31210637Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.Elife2019
31618757HP1 reshapes nucleosome core to promote phase separation of heterochromatin.Nature2019
29452642The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding.Mol Cell2018
30471698Visualization and Quantitation of Phase-Separated Droplet Formation by Human HP1α.Methods Enzymol2018
29644850The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.Biochemistry2018
29664398The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h.Elife2018
28636604Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.Nature2017
28104838Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.Science2017
28942089Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.J Mol Biol2017
28591576Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.Cell Rep2017
27372751Analysis of Nucleosome Sliding by ATP-Dependent Chromatin Remodeling Enzymes.Methods Enzymol2016
27391925Mechanisms of ATP-Dependent Chromatin Remodeling Motors.Annu Rev Biophys2016
27130520Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.Elife2016
25684208A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler.Mol Cell2015
25997164A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.PLoS One2015
24618358Mechanisms of functional promiscuity by HP1 proteins.Trends Cell Biol2014
24607692The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme.J Mol Biol2014
23485968A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.Nature2013
23911317Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes.Cell2013
23849629Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.Mol Cell2013
23601638Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.Chem Biol2013
22183603Analysis of changes in nucleosome conformation using fluorescence resonance energy transfer.Methods Mol Biol2012
22733737Ers1 links HP1 to RNAi.Proc Natl Acad Sci U S A2012
21211724Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.Mol Cell2011
22096199Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 ÿ resolution.Science2011
21673141Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress.Proc Natl Acad Sci U S A2011
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Collaborators

Robert E Kingston
Co-authored papers 15
Hiten D Madhani
University of California san francisco
Co-authored papers 9
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 7
Alma L Burlingame
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 7
Caitlin I Stoddard
Fred Hutchinson Cancer Center.
Co-authored papers 6
Michael J Trnka
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 5
Coral Y Zhou
University of California berkeley
Co-authored papers 4
John D Gross
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Jean-Paul Armache
Center for Eukaryotic Gene Regulation, Pennsylvania State University, University Park
Co-authored papers 4
Un Seng Chio
University of California san francisco
Co-authored papers 3
Shixin Liu
The Rockefeller University
Co-authored papers 2
Xi He
Boston Children's Hospital, Harvard Medical School
Co-authored papers 2
Jonathan K Pritchard
Co-authored papers 2
John R Yates
TheScripps Research Institute
Co-authored papers 2
Harold Pimentel
Co-authored papers 2
Jonathan B Johnston
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Eugene Palovcak
University of California San Francisco
Co-authored papers 2
Shenping Wu
Yale University
Co-authored papers 2
Barbara Panning
University of California san francisco
Co-authored papers 2
David A Agard
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Melody G Campbell
Fred Hutchinson Cancer Center
Co-authored papers 1
Feng Wang
University of California san francisco
Co-authored papers 1
Sigurd Braun
Biomedical Center, Ludwig-Maximilians-Universitat of Munich
Co-authored papers 1
Feixia Chu
University of New Hampshire
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Xin Zhang
Co-authored papers 1
Patrick R Griffin
The Scripps Research Institute
Co-authored papers 1
Susan C Shih
Northwestern University
Co-authored papers 1
Release 1.2