Author details

Full Name

Diana van Heemst

Affiliation

ORCID

Career Start Year

1997

Papers

259

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37923847	The ageing thyroid: implications for longevity and patient care.		2024
37544278	Habitual sleep quantity and quality and the risk of obesity: What's the chicken, and what's the egg?		2023
36372091	Setting your clock: associations between timing of objective physical activity and cardiovascular disease risk in the general population.	European Journal of Preventive Cardiology	2023
36129566	The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective.	GeroScience	2023
38028628	Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.	Front Genet	2023
37862463	Incidence and determinants of spontaneous normalization of subclinical hypothyroidism in older adults.		2023
37858220	Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.	Clin Epigenetics	2023
36719767	Epigenome-Wide Association Study Reveals CpG Sites Associated with Thyroid Function and Regulatory Effects on KLF9.	Thyroid	2023
37268178	A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases: A case study using Danish registries for an FDA warning on lamotrigine.		2023
37017544	Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways.	Liver Int	2023
37453811	The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review.		2023
37257353	Cardiovascular risk factors and major recurrent coronary events: A genetic liability study in patients with coronary artery disease in the UK Biobank.		2023
37254031	Differential and sex- and age-specific risks of cardiometabolic diseases with unrelated metabolic syndrome dimensions.		2023
36536985	Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study.	Cardiovasc Res	2023
37500025	The impact of sociodemographic status on the association of classical cardiovascular risk factors with coronary artery disease: a stratified Mendelian randomization study.		2023
34932184	Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization.	GeroScience	2022
35656699	Clustered Mendelian randomization analyses identify distinct and opposing pathways in the association between genetically influenced insulin-like growth factor-1 and type 2 diabetes mellitus.	International Journal of Epidemiology	2022
35894851	Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials.	J Intern Med	2022
35381390	Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial.	Bone	2022
35689786	Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study.	GeroScience	2022
35867128	Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study.	Diabetologia	2022
35793595	The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses.	Atherosclerosis	2022
35980264	The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging.	Aging	2022
36187563	Agreement between nicotine metabolites in blood and self-reported smoking status: The Netherlands Epidemiology of Obesity study.	Addictive Behaviors Reports	2022
36552530	Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?		2022
33355649	Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end-stage renal disease.	Nephrology Dialysis Transplantation	2022
34739073	Depression and Inflammatory Bowel Disease: A Bidirectional Two-sample Mendelian Randomization Study.		2022
34514498	Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank.	Journal of Clinical Endocrinology and Metabolism	2022
35218666	No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials.	Journal of Clinical Endocrinology and Metabolism	2022
34782736	Timing of objectively-collected physical activity in relation to body weight and metabolic health in sedentary older people: a cross-sectional and prospective analysis.	International Journal of Obesity	2022
34534944	Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals.	Nutrition	2022
34702360	Validating biomarkers and models for epigenetic inference of alcohol consumption from blood.	Clin Epigenetics	2021
33972266	Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles.		2021
33859359	Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.	Mol Psychiatry	2021
33593663	Urinary oxidized, but not enzymatic vitamin E metabolites are inversely associated with measures of glucose homeostasis in middle-aged healthy individuals.	Clinical Nutrition	2021
33804309	Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes.	Journal of Clinical Medicine	2021
33901276	Genetically Determined Higher TSH Is Associated With a Lower Risk of Diabetes Mellitus in Individuals With Low BMI.	Journal of Clinical Endocrinology and Metabolism	2021
33893282	Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes.	Nat Commun	2021
34158242	Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals.	Nutrition, Metabolism and Cardiovascular Diseases	2021
33731105	Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses.	BMC Med	2021
33517400	Genome-wide association study of circulating interleukin 6 levels identifies novel loci.	Hum Mol Genet	2021
34106350	Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study.	Metabolomics	2021
33716972	Within-Person Variation in Serum Thyrotropin Concentrations: Main Sources, Potential Underlying Biological Mechanisms, and Clinical Implications.	Frontiers in Endocrinology	2021
33500576	Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions.	Eur J Hum Genet	2021
34337275	Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men.	Journal of the Endocrine Society	2021
34082327	Apolipoprotein E genotype, lifestyle and coronary artery disease: Gene-environment interaction analyses in the UK Biobank population.	Atherosclerosis	2021
33112260	Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis.	European Journal of Endocrinology	2021
33058961	Interplay of circulating leptin and obesity in cognition and cerebral volumes in older adults.	Peptides	2021
33413940	Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.	Journal of the American College of Cardiology	2021
33413165	Design and rationale of a routine clinical care pathway and prospective cohort study in older patients needing intensive treatment.	BMC Geriatrics	2021