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Author Details

Yanjie Yi
Perelman School of Medicine, University of Pennsylvania
1996
47
22
Sarah J Ratcliffe (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37384350Label-free detection of synthetic, full genomic length HIV-1 RNA at the few-copy level.Sens Actuators B Chem2023
37578230A high-throughput screening assay for silencing established HIV-1 macrophage infection identifies nucleoside analogs that perturb H3K9me3 on proviral genomes.J Virol2023
35319230Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage.J Virol2022
35621385Highly restricted SARS-CoV-2 receptor expression and resistance to infection by primary human monocytes and monocyte-derived macrophages.J Leukoc Biol2022
33999045An integrated self-powered 3D printed sample concentrator for highly sensitive molecular detection of HIV in whole blood at the point of care.Analyst2021
31844418Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.Cell Mol Biol Lett2019
29659623Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses.PLoS Pathog2018
27903799CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections.J Virol2017
28251988Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge.Nat Commun2017
29023549Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.PLoS Pathog2017
25344286Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing.Genome Biol2014
23824793CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.J Virol2013
24219995Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo.Retrovirology2013
21284902R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies.J Transl Med2011
22005304Depletion of CD4[+] T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.J Clin Invest2011
20381825Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry.Virology2010
19515785Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization.J Virol2009
19692476Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.J Virol2009
18197116Entry coreceptor use and fusion inhibitor T20 sensitivity of dual-tropic R5X4 HIV-1 in primary macrophage infection.J Acquir Immune Defic Syndr2008
18641344HIV envelope binding by macrophage-expressed gp340 promotes HIV-1 infection.J Immunol2008
15650174Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytes.J Virol2005
15114024Use of dual recombinant vaccinia virus vectors to assay viral glycoprotein-mediated fusion with transfection-resistant primary cell targets.Methods Mol Biol2004
14982745Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis.J Neurovirol2004
14581542Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies.J Virol2003
12960231Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.J Leukoc Biol2003
12907388An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis.J Neurovirol2003
11461681Concordant utilization of macrophage entry coreceptors by related variants within an HIV type 1 primary isolate viral swarm.AIDS Res Hum Retroviruses2001
11277696Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5delta32) and normal human lymphoid tissue.Virology2001
11274418Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.Proc Natl Acad Sci U S A2001
11352675A CCR5/CXCR4-independent coreceptor pathway on human macrophages supports efficient SIV env-mediated fusion but not infection: implications for alternative pathways of viral entry.Virology2001
11507195Human immunodeficiency virus type 1 IIIB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism.J Virol2001
10985246Chemokine signaling and HIV-1 fusion mediated by macrophage CXCR4: implications for target cell tropism.J Leukoc Biol2000
10985247Co-receptor usage was more predictive than NSI/SI phenotype for HIV replication in macrophages: is NSI/SI phenotyping sufficient?J Leukoc Biol2000
10487781Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.J Clin Invest1999
10438797Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.J Virol1999
10099111Cofactors for human immunodeficiency virus entry into primary macrophages.J Infect Dis1999
10488761A macrophage fusion assay for rapid screening of cloned HIV-1 Env using dual recombinant vaccinia viruses expressing distinct RNA polymerases.J Virol Methods1999
9733831An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus.J Virol1998
9420285CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1.J Virol1998
9557745Determinants of entry cofactor utilization and tropism in a dualtropic human immunodeficiency virus type 1 primary isolate.J Virol1998
9696841Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4.J Virol1998
9060685Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.J Virol1997
9171220Abortive infection in HeLaCD4 cells by a primary HIV type 1 isolate: implications for differential host cell tropism.AIDS Res Hum Retroviruses1997
9371556Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.J Virol1997
8674120A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.Cell1996
8751444Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.Nature1996
8898197Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity.Cell1996
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Collaborators

University of Pennsylvania School of Medicine
Co-authored papers 45
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 4
University of Washington
Co-authored papers 4
IF School of Medicine, University of Pennsylvania
Co-authored papers 3
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Co-authored papers 3
Co-authored papers 3
University of Virginia
Co-authored papers 3
University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
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Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Co-authored papers 1
Children's Hospital of Philadelphia
Co-authored papers 1
Co-authored papers 1
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
Emory University
Co-authored papers 1
National Cancer Institute
Co-authored papers 1
Rollins School of Public Health, Emory University
Co-authored papers 1
Center for Family Health Research Zambia
Co-authored papers 1
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 1
National Institute of Allergy and Infectious Disease, National Institute of Health
Co-authored papers 1
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University of Pennsylvania Perelman School of Medicine
Co-authored papers 1
Columbia University Medical Center
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1